Key Researchers

Prof AUNG Tin

Prof AUNG Tin

MBBS(S’pore), MMed(Ophth), FRCS(Ed), FRCOphth(UK), FAMS, PhD(Lond)

Executive Director
Head, Glaucoma Research Group
Head, Clinical Research & Trials Support Platform

Email: aung.tin@singhealth.com.sg

Professor Aung is a clinician scientist, with clinical practice focusing on glaucoma and research interests in angle closure glaucoma and glaucoma genetics. With more than 450 publications, Professor Aung has been awarded more than US$20 million in competitive research grant funding. He has received numerous awards including the Singapore Translational Research (STaR) Investigator Award in 2014, the Singapore National Medical Research Council-Clinician Scientist Awards in 2005 and 2008, the President’s Science Award in 2009, the Nakajima (2007) and De Campo Awards (2013) from the Asia Pacific Academy of Ophthalmology and the Alcon Research Institute Award in 2013.

Professor Aung is a member of the Editorial Boards of Ophthalmology, Journal of Glaucoma, Eye, Graefe’s Archive for Clinical and Experimental Ophthalmology, and 6 other journals. He is currently President of the World Glaucoma Association and also serves as a Board member of the Asia-Pacific Glaucoma Society and the Asian Angle Closure Glaucoma Club.

  • Deputy Medical Director (Research), Singapore National Eye Centre
  • Senior Consultant and Head, Glaucoma Department
  • Academic Vice Chair (Research), Academic Clinical Program for Ophthalmology and Visual Sciences, SingHealth / Duke-NUS Medical School
  • Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore

Research Interests

Angle Closure Glaucoma, Ophthalmic genetics, genetic basis of glaucoma, Quantitative traits of ocular diseases, endophenotype gene mapping

Education

  • 1990
MBBS National University of Singapore
  • 1997
Master of Medicine (Ophthalmology) National University of Singapore
  • 1997
FRCSEd Royal College of Surgeons of Edinburgh
  • 1997
FRCOphth Royal College of Ophthalmologists
  • 2000
Advanced Specialty Training in Ophthalmology Singapore
  • 2003
FAMS Academy of Medicine, Singapore
  • 2004
PhD (in Molecular Genetics) University College London, University of London, UK

Previous Positions

  • 2000 – Fellow, Department of Molecular Genetics, University College London

Awards

  • 2016
SingHealth Excellence 2016 Awards – Distinguished Visionary Leader Award
  • 2016
NUS University Awards 2016 – Outstanding Researcher Award
  • 2016
ARVO Fellow (Silver Award)
  • 2014
Singapore Translational Research (STaR) Investigator Award, National Medical Research Council, Singapore
  • 2014
Senior Achievement Award, American Academy of Ophthalmology
  • 2013
Alcon Research Institute Award
  • 2013
De Campo Lecture Award, Asia Pacific Academy of Ophthalmology
  • 2012
Faculty Outstanding Researcher Award, Yong Loo Lin School of Medicine, National University of Singapore
  • 2010
Asia Pacific Academy of Ophthalmology Achievement Award
  • 2009
President’s Science Award, A-STAR, Singapore
  • 2009
Singhealth GCEO Excellence Award in Biomedical Research
  • 2008
National Medical Research Council – Biomedical Research Council Clinician Scientist Award (Senior Category)
  • 2008
Distinguished Achievement Award, American Academy of Ophthalmology
  • 2007
Nakajima Award and Lecture, Asia Pacific Academy of Ophthalmology
  • 2005
National Medical Research Council – Biomedical Research Council Clinician Scientist Investigator Award (Junior Category)
  • 2001
ARVO / Santen Pharmaceutical Travel Fellowship Award, ARVO, USA
  • 2000
National Medical Research Council Singapore Totalisator Board Medical Research Fellowship
  • 1997
Grace Ballas Travelling Fellowship, National Medical Research Council, Singapore

Ophthalmology & Scientific Involvement

  • President, World Glaucoma Association (2016 – date)
  • Board Member, Asia Pacific Glaucoma Society
  • Board Member, Asian Angle Closure Glaucoma Club
  • Member, Academia Ophthalmologica Internationalis (2016 – date)
  • Member, Glaucoma Research Society (2009 – date)
  • Council Member, College of Ophthalmologists, Singapore
  • Chairman, National Medical Research Council CS-IRG Local Review Panel (since 2014)

Selected Publications

  1. Khor CC, Do T, Jia H, Nakano M, George R, …. Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genetics. 2016 May; 48(5):556-62.
  2. Aung T, Ozaki M, Mizoguchi T, Allingham RR, …. Khor CC. A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome. Nature Genetics 2015; 47(4):387-92.
  3. Hysi PG, Cheng CY, Springelkamp H, Macgregor S, …. Aung T. Genome-wide Analysis of Multiethnic Cohorts Identifies Four New Loci Influencing Susceptibility to Increased Intraocular Pressure and Susceptibility to Glaucoma. Nature Genetics 2014; 46(10): 1126-30.
  4. Nongpiur ME, Khor CC, Jia H, Nair KS, …. Aung T. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014; 10(3): e1004089.
  5. Vithana EN, Khor CC, Qiao C, Nongpiur ME, …. Aung T. Genome-wide association analyses identify three new susceptibility loci for Primary Angle Closure Glaucoma. Nature Genetics 2012; 44: 1142-6.
  6. Vithana EV, Morgan P, Sundaresan P, Ebenezer N, Tan DT, Anand S, Khine KO, Venkataraman D, Yong V, Salto-Tellez M, Venkataraman A, Guo K, Heemadevi B, Mohamad M, Srinivasan M, Prajna V, Khine M, Casey JR, Inglehearn C, Aung T. Mutations in Na-borate co-transporter SLC4A11 cause recessive Congenital Hereditary Endothelial Dystrophy, CHED2. Nature Genetics, 2006; 38: 755-7.
  7. Weinreb RN, Aung T, Medeiros FA. The Pathophysiology and Treatment of Glaucoma: A Review. JAMA. 2014 May 14; 311(18):1901-11.

Dr Veluchamy Amutha BARATHI

Dr Veluchamy Amutha BARATHI

Junior Principal Investigator
Assistant Director, Translational Preclinical Model Platform
Head, Translational Pre Clinical Model Support Platform

Email: amutha.b.veluchamy@seri.com.sg

I head the Ocular Translational Pre-Clinical Model Research Platform at the Singapore Eye Research Institute where I hold the position of a Senior Research Scientist. I am an adjunct Assistant Professor at the Department of Ophthalmology, National University of Singapore and National University Hospital and at DUKE-NUS Graduate Medical School. I am a Vet & molecular biologist with research focused on understanding the molecular mechanism of myopia, glaucoma, diabetic retinopathy and Age-related Macular Degeneration (AMD). My research has led to the translational and pre-clinical testing of ocular diseases using specific animal models. I have published more than 30 peer-reviewed papers. I have vast experience in lab animals and my specialization encompasses non-human primates, rabbits, mice, rats, pigs and chicken. I am currently collaborating with five international institutes and six inter-institutions. I regularly peer reviews at least four international journals and also regularly reviews SingHealth IACUC animal study protocols. Currently holds competitive research grants from National Medical Research Council (NMRC) and Biomedical Research Council (BMRC). I am a chairman of Singhealth Institutional Animal Care and Use Committee (IACUC).

Other concurrent positions

    • Adjunct Assistant Professor, Yong Loo Lin School of Medicine, National University of Singapore
    • Adjunct Assistant Professor, DUKE-NUS Graduate Medical School
    • Chairman, Singhealth Institutional Animal Care and Use Committee (IACUC)

 

Research Interests

Animal models of ocular diseases, Pathophysiology and pharmacological intervention of Myopia, Diabetic Retinopathy, Glaucoma and AMD

Education

  • 2006
PhD Department of ophthalmology, NUS
  • 1997
BVSc TamilNadu Veterinary Animal Sciences University, Chennai, India

Previous Positions

  • Non-human Primate veterinary Research Trainee, University of Washington, USA;
  • Overseas Fellow, University of Tuebingen, Germany

 

Awards

  • 2004
Young Investigator Award, Visual Science (Outstanding)
  • 2007
Singhealth Short-term Fellowship Award
  • 2008
ARVO International Travel Award
  • 2010
Novartis Research Prize, NHG 3rd International Ophthalmology Congress

Ophthalmology & Scientific Involvement

  • Member, Scientific Review Committee, SERI
  • Member, Association for Research in Vision and Ophthalmology (ARVO), USA.
  • International Organizing Committee and Symposium Organizer, 13th International Myopia Conference, 2010, Tubingen, Germany
  • Scientific Organizing Committee Member, ASIA-ARVO, 2011, Singapore
  • Symposium Moderator, 11th International Myopia Conference, Tubingen, Germany
  • Chairman, Myopia Symposium, ASIA-ARVO 2011, Singapore
  • Moderator, ASIA-ARVO 2011, Singapore
  • International Organizing Committee, 14th International Myopia Conference, 2013, Berkeley, USA.

 

Selected publications

  1. Lai CM, Shen WY, Brankov M, Lai YK, Barnett NL, Lee SY, Yeo IY, Mathur R, Ho JE, Pineda P, Barathi A, Ang CL, Constable IJ, Rakoczy EP. Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys. Mol Ther 2005; 12(4):659-668. IF = 6.825
  2. Lei Zhou, Roger W Beuerman, Liqun Huang, Amutha Barathi, Yong Hwee Foo, Sam F. Y. Li, Fook Tim Chew and Donald Tan. Proteomic analysis of rabbit tear fluid: Defensin levels after an experimental corneal wound are correlated to wound closure. Proteomics 2007; 7(17): 3194-3206. IF = 5.479
  3. Barathi VA, Boopathi VG, Yap EP, Beuerman RW. Two models of experimental myopia in the mouse. Vision Res. 2008 Mar;48(7):904-16. IF = 2.512
  4. Barathi VA, Beuerman RW and Schaeffel F. Effects of unilateral topical atropine on binocular pupil responses and eye growth in mice. Vision Research, 2009, Mar;48(7):904-16. IF = 2.512
  5. Barathi VA, Weon SR and Beuerman RW. Expression of Muscarinic Receptors in Human and Mouse Sclera and their Role in the Regulation of Scleral Fibroblasts Proliferation. Mol Vis, 2009, 15:1277-1293. IF = 2.33
  6. Barathi VA, Weon SR, Queenie SWT, Lin KJ, Tong L, Beuerman RW. Transglutaminases (TGases) in Ocular and Periocular Tissues: Effect of Muscarinic Agents on TGases in Scleral Fibroblasts. PLOS One. 2011 Apr 6;6(4):e18326. IF = 4.56.
  7. Remya Robinson, Candice E. H. Ho, Queenie S. W. Tan, Chi D. Luu, Kyaw T. Moe, Carol Y. Cheung, Tien Y. Wong, Veluchamy A Barathi+. Fluvastatin Downregulates VEGF-A Expression in TNF-α –Induced Retinal Vessel Tortuosity, 2011 Sep 27;52(10):7423-31. IOVS. IF: 3.431.
  8. Remya Robinson1*, Veluchamy A. Barathi*, Shyam S. Chaurasia, Tien Y. Wong, Timothy S. Kern. Current update on animal models of diabetic retinopathy. 2012. Dis Model Mech. 2012 Jul;5(4):444-56. IF: 4.584.
  9. Fan Q, Barathi VA, Cheng CY, Zhou X, Meguro A, Nakata I, Khor CC, Goh LK, Li YJ, Lim W, Ho CE, Hawthorne F, Zheng Y, Chua D, Inoko H, Yamashiro K, Ohno-Matsui K, Matsuo K, Matsuda F, Vithana E, Seielstad M, Mizuki N, Beuerman RW, Tai ES, Yoshimura N, Aung T, Young TL, Wong TY, Teo YY, Saw SM.Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. PLoS Genet. 2012 Jun;8(6):e1002753. Epub 2012 Jun 7. IF: 9.543.
  10. C-M Lai, M J Estcourt, R P Himbeck, S-Y Lee, Yew-San Yeo, C Luu, B K Loh, M W Lee, A Barathi, J Villano, C-L Ang, R G van der Most, I J Constable, D Dismuke, R J Samulski, M A Degli-Esposti and E P Rakoczy. Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates. Gene Ther. 2012 Oct;19(10):999-1009. IF: 4.5.
  11. Tran-Viet KN, Powell C, Barathi VA, Klemm T, Maurer-Stroh S, Limviphuvadh V, Soler V, Ho C, Yanovitch T, Schneider G, Li YJ, Nading E, Metlapally R, Saw SM, Goh L, Rozen S, Young TL. Mutations in SCO2 Are Associated with Autosomal-Dominant High-Grade Myopia. Am J Hum Genet, 2013 May 2;92(5):820-6. IF: 10.603.
  12. Barathi VA+, Kwan JL, Tan QS, Weon SR, Li Fong S, Goh LK, Vithana EN, Beuerman RW. Muscarinic Cholinergic Receptor (M2) Plays A Critical Role In The Development Of Myopia. Dis Model Mech. 2013 May 2. IF: 4.584.
  13. Jayaganesh V. Natarajan, Anastasia Darwitan, Veluchamy A. Barathi, Marcus Ang, Hla Myint Htoon, Freddy Boey, Kam C. Tam, Tina T. Wong, Subbu S. Venkatraman. Sustained Drug Release in Nanomedicine: A Long-Acting Nanocarrier-Based Formulation for Glaucoma. Accepted in ACS Nano, Jan 6 2014. IF: 12.06.
  14. Veluchamy A Barathi, Michael Poidinger, Siew Kwan Koh, Candice E.H. Ho, Roger W Beuerman, Lei Zhou. Involvement of GABA transporters in Atropine-treated Myopic Retina as revealed by iTRAQ Quantitative Proteomics. J. Proteome Res., 2014, 13 (11), pp 4647–4658. JPR. IF: 5.001.
  15. Radhakrishnan Sridhar, Rajamani Lakshminarayanan, Kalaipriya Madhaiyan, Veluchamy A. Barathi, Keith Hsiu Chin Lim and Seeram Ramakrishna. Eectrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals. In Press, 2014, Chem Soc Rev. IF: 30.425.

Prof Michael BELKIN

Prof Michael BELKIN

MA, M.D

Senior Scientific Advisor

Email: belkin@netvision.net.il

Professor Belkin is a leading internationally recognized eye researcher, an author of over 200 scientific publications and over 20 patents and who received various research awards. His laboratory is dedicated to originating and enabling the transfer of technologies from inception and university-level research to clinical practice by providing expertise and facilities for laboratory, preclinical and clinical studies. He is involved in several such projects at various stages of development in lasers, optics, ophthalmic devices, pharmaceutics and biotechnology and in recent year he participated in establishing a few startup companies. One of his ideas, the ExPRESS miniature glaucoma implant, is in routine use internationally.

He has recently shown that a hereditary retinal degeneration can be effectively treated. This is the first time that a genetically based retinal degeneration was proven treatable. He is now dedicated to performing clinical trials to determine whether such therapy is efficacious in treating other congenital and acquired retinal diseases.

Other concurrent positions

  • Professor Emeritus of Ophthalmology, Tel Aviv University
  • Director of the Ophthalmic Technologies Laboratory, Eye Research Institute in the Sheba Medical Center, Tel Aviv University

 

Research Interests

Ophthalmic technologies, translational research in ophthalmology, lasers, optics, stem cells, pharmaceutics, biotechnology

Education

  • 1961
B.A. and M.A. [Natural Sciences] Cambridge University, England Honours
  • 1965
M.D [Medicine] Hebrew University, Jerusalem
  • 1970
Jerusalem Ophthalmology Residency Hadassah University Hospital

Previous Positions

  • 1974
Head of Pediatric Ophthalmology service, Hadassah University Hospital, Jerusalem
  • 1975
Lecturer in Ophthalmology, Hebrew University Jerusalem
  • 1975
Chief Physician in Ophthalmology, Hadassah University Hospital Jerusalem
  • 1976
Head of Research, Development & NBC medicine- Medical Corps, Israel Defense Forces
  • 1979
Visiting Scientist, Ocular Hazards Division Letterman Army Research Institute, San Francisco
  • 1981
Associate Professor, Faculty of Medicine, Tel-Aviv University.
  • 1981
Director, Goldschleger Eye Research Institute, Tel-Aviv University
  • 1981
Director of Ophthalmic Technologies Laboratory, Goldschleger Eye Research Institute
  • 1981
Head, Pediatric Ophthalmology Service, Sheba Medical Center Tel Hashomer, Israel
  • 1987
Professor of Ophthalmology, Faculty of Medicine, Tel Aviv University
  • 1988
Chairman Department of Ophthalmology, Faculty of Medicine, Tel Aviv University
  • 1994
Visiting Professor, Medical Research Detachment, Walter Reed Army Institute of Research
  • 2006
Senior Consultant, Singapore Eye Research Institute
  • 2006
Sidney A. Fox Chair of Ophthalmology, Tel Aviv University

Awards

  • 2006
Sidney A. Fox Chair of Ophthalmology, Tel Aviv University
  • 2000
Gothelf Prize, Tel Aviv University
  • 1998
Stein Research Prize, Tel Aviv University
  • 1995
Stein Research Prize, Tel Aviv University
  • 1990
Edwin S. Beatrice Memorial Lecture, U.S. Army
  • 1990
Merit Award and Medal, International Congress of Ophthalmology
  • 1989
Stein Research Prize, Tel Aviv University
  • 1985
Stein Research Prize, Tel Aviv University
  • 1976
Israel Medical Association, Landau Research Prize

Ophthalmology & Scientific Involvement

  • President, Israel Society for Eye and Vision Research
  • Chairman, Committee for Planning of Ophthalmic Care during National Emergencies
  • Deputy Chairman , Sheba Medical Center Human Use in Biomedical Experiments (IRB) Committee
  • Senior Advisor in Ophthalmology to the Surgeon General, Medical Corps, Israel Defense Forces
  • Chairman, Permanent Advisory Committee in Ophthalmology, Ministry of Health, Israel
  • Chairman, Interministerial Committee for the Usage and Safety of Video Display Terminals
  • Member, Board of Directors, Tel Aviv University Authority for Applied Research and Industrial Development
  • Chairman, Advisory Committee for Registration of Ophthalmic Preparations, Ministry of Health, Israel
  • Member, International Advisory Board, “Survey of Ophthalmology”.
  • Chairman, Ophthalmology Committee, National Councils for Health, Israel
  • Chairman, Commercial Relationship Committee, Association for Research in Vision and Ophthalmology (ARVO)
  • Board member, Optonol (ExPRESS) LTD
  • Board member, OphthaliX LLC
  • Member, Israel Medical Association
  • Member, Israel Ophthalmological Society
  • Member, Israel Association for Medical and Biological Engineering
  • Member, Israel Society for Eye and Vision Research (Founding member)
  • Member, Association for Research in Vision and Ophthalmology (ARVO)
  • Member, International Society for Optical Engineering (SPIE)
  • Member, American Academy of Ophthalmology
  • Member, International Society for Ocular Trauma (Founding member)
  • Member, Biomedical Optics Society (BIOS)
  • Member, American Glaucoma Society

 

Selected publications from over 200 publications

  1. Schwartz, M., Belkin, M., Harel, A., Solomon, A., Lavie, V., Hadani, M., Rachilovich, I. and Stein-Izsak, C.Regenerating fish optic nerves and a regeneration-like response in
  2. injured optic nerves of adult rabbits Science 228: 601-603, 1985
  3. Eitan, S., Solomon, A., Yoels, E., Lavie, V., Hirschberg, D.L., Belkin, M. and Schwartz M.Recovery of visual response of injured adult rat optic nerves treated with transglutaminase. Science 264: 1764-1768, 1994.
  4. Rapalino, O., Lazarov-Spiegler, O., Agranov, G., Velan, G., Yoles, E., Solomon, A.,
  5. Gepstein, R., Katz, A., Belkin, M., Hadani, M. and Schwartz, M. Implantation of stimulated macrophages leads to partial recovery of paraplegic rats. Nature Medicine 4:814-821, 1998.
  6. Polat, U., Ma-Naim, T., Belkin, M. and Sagi, D.Improving vision in adult amblyopia by perceptual learning.Proc. Nat. Acad. Sci. 101:6692-6697,2004
  7. Traverso, C., De Feo, F., Messas-Kaplan, A., Denis, P., Levartorsky, S., Sellem, E., Badala, F., Zagorski, Z., Bron, A.and Belkin, M. Long term effects of a stainless steel glaucoma implant (ExPRESS) in combined surges with phacoemulsification.Brit. J. Ophth. 89: 425-429, 2005
  8. Barequet I.S., Habot-Wilner, Z, Keller, N., Smollan, G., Ziv, H., Belkin, M and Rosner, M.
  9. Effect of amniotic membrane transplantation on the healing of bacterial keratitis. Invest. Ophth. Vis. Sci.49:163–167, 2008
  10. Ho CL, Lai JS, Aquino MV, Rojanapongpun P, Wong HT, Aquino MC, Gerber Y, Belkin M, Barkana Y. Selective laser trabeculoplasty for primary angle closure with persistently elevated intraocular pressure after iridotomy. J Glaucoma. 2009 Sep;18(7):563-6.
  11. Rotenstreich, Y. Harats, D., Shaish, A., Pras, E. and Belkin, M. Treatment of a Retinal Dystrophy, Fundus Albipunctatus, with Oral 9-Cis Beta-Carotene,Brit. J. Ophth. 94:616-621, 2010
  12. Lahav K., Levkovitch-Verbin H., Belkin M., Glovinsky Y. and Polat U.Reduced mesopic and photopic foveal contrast sensitivity in glaucoma, Arch. Ophth. 129: 116-22. 2011
  13. Rotenstreich, Y., Belkin, M., Sadetzki, S., Chetrit. A.,Ferman-Attar, G., Sher, I. Harari, A., Shaish, A. and Harats, D. A Randomized crossover trial of 9-cis β-Carotene rich powder in retinitis pigmentosa patients. JAMA Ophthalmology: Published online May 2013

Prof Roger BEUERMAN

Prof Roger BEUERMAN

Senior Scientific Advisory
Head, Anti-Infectives Research Group
Head, Biomarkers Research Group

Email: roger.wilmer.beuerman@seri.com.sg

Prof Roger is currently Senior Scientific Director of the Singapore Eye Research Institute, Professor of Neuroscience and Behavioral Disorders at DUKE-NUS School of Medicine and Adjunct Professor of Ophthalmology, Yong Loo Lin, School of Medicine at the National University of Singapore, Adjunct Professor of Chemical and Biomedical Engineering at Nanyang Technological University and Senior Scientist at the Bioinformatics Institute. He has more than 20 years in ophthalmology. Proteomic biomarkers of eye disease and development of new antimicrobial peptides are major areas of concentration. He has worked to develop methods for analyzing the microliter volumes of tears from the eye as a diagnostic source and looks to developing population based studies in proteomics. He is an ARVO Fellow, a Fellow of the Alcon Research institute, and the Paolo Foundation in Helsinki, Finland. In 2009 he was the recipient of the President’s (Singapore) First Science and Technology Award. Overall, he has more than 220 publications sits on several editorial boards.

Other concurrent positions

  • Professor, Duke-NUS, SRP Neuroscience & Behavioural Disorders
  • Adjunct Professor, Biochemistry Dept of Biochemistry, NUS, Yong Loo Lin School of Medicine
  • Director SingHealth Medical Proteomics Center
  • Programe Director, Proteomics Core Platform Research Tower Space Allocation Committeee (SAC) & SGH Pathology Building Central Steering Committee (CSC)
  • Adjunct Professor, School of Chemical and Biomedical Engineering Nanyang Technological University

 

Research Interests

Development of novel antimicrobials for use in ophthalmology, proteomic studies revealing biomarkers of eye disease, and myopia.

Education

  • 1965
B.S. Psychology, Frederick College, Portsmouth, Virginia
  • 1973
PhD Florida State University, Tallahassee, Florida

Previous Positions

  • 2008
Chairman Advisory Committee, SingHealth Experimental Medicine Centre
  • 2009
Adjunct Professor Duke-NUS, Graduate Medical School Dept of Ophthalmology
  • 2010
Adjunct Scientist, Bioinformatics Institute

Awards

  • 2009
ARVO Silver Fellow
  • 2009
President’s First Science and Technology Award, Singapore
  • 2012
FidiPro National Distinguished Professor, University of Tampere Medical School, Finland
  • 2013
ARVO Fellow (Gold Award)
  • 2014
Guest Professor Award, Southeastern Chinese University of Technology, Guangzhou, China

Selected publications

  1. Liu SP, Zhou L, Lakshminarayan R, Beuerman RW. Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversitites. Int J Pept Res Ther 2010 Sep; 16(3):199-213
  2. Hong Yuan Zhu, A K Riau, R W Beuerman. Epithelial microfilament regulators show regional distribution in mouse conjuctiva. Molecular Vision 2010; 16:2215-2224 Oct 31, 2010.
  3. Barathi VA, Beuerman RW. Molecular mechanisums of muscarinc receptors in mouse scleral fibroblasts: Prior to and after induction of experimental myopia with atropine treatment. Mol Vis 2011 Mar9;17:680-92
  4. Zhou L, Liu SP, Li J, Ong LB, Guo L, Wohland T, R. Lakshminarayanan, Tang C, Mavinahalli J, Verma C, Beuerman RW. The structural parameters for antimicrobial activity, human epithelia cell cytotoxicity and killing mechanism of synthetic monomer and dimer analogues derived from hBD3 C-terminus region. Amino Acids 2011 Jan;40(1):123-133
  5. Ang LP, Do TP, Thein ZM, Reza HM, Tan XW, Yap C, Tan DT, Beuerman RW. The Ex Vivo Expansion of Conjunctival and Limbal Epithelial Cells using Cord Blood Serum-Supplemented Culture Medium. Invest Ophthalmol Vis Sci 2011 Apr 7 [Epub ahead of print].
  6. Barathi VA, Weon SR, Tan QS, Lin KJ, Tong L, Beuerman RW. Transglutaminases (TGs) in ocular and periocular tissues:Effect of muscarinic agents on TGs in scleral fibroblasts. PloS One 2011 Apr 6;6(4):e18326
  7. Jing Li, Lei Zhou, Roger W Beuerman. Defensins: Key Molecules in Ocular Surface Protection. Current Immunology Reviews, Vol 7, Number 3, Aug 2011 Page 295-307.
  8. Lei Zhou, Roger W Beuerman. The Role of Biomarker in Personalised Medicine: Concept, Technology and Challenges. Asia Pacific Biotech, August 2011, Vol 15 No. 8, Page 14-17.
  9. Li J, Riau AK, Setiawan M, Mehta JS, Ti SE, Tong L, Tan DT, Beuerman RW. S100A expression in normal corneal-limbal epithelial cells and ocular surface squamous cell carcinoma tissue. Mol Vis. 2011;17:2263-71. Epub 2011 Aug 20.
  10. Chen L, Zhou L, Chan EC, Neo J, Beuerman RW. Characterization of the human tear metabolome by LC-MS/MS J Proteome Res. 2011 Oct 7;10(10):4876-82. Epub 2011 Aug 30.
  11. Barathi VA, Kwan JL, Tan QS, Weon SR, Seet LF, Goh LK, Vithana EN, Beuerman RW. Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice. Dis Model Mech. 2013 Sep-Oct;6(5):1146-58.
  12. Lakshminarayanan R, Liu S, Li J, Nandhakumar M, Aung TT, Goh E, Chang JY, Saraswathi P, Tang C, Safie SR, Lin LY, Riezman H, Lei Z, Verma CS, Beuerman RW. Synthetic Multivalent Antifungal Peptides Effective against Fungi. PLoS One. 2014 Feb 3;9(2):e87730.

Dr Anita CHAN

Dr Anita CHAN

Clinician Scientist

Email: anita.chan.s.y@singhealth.com.sg

Dr Anita Chan graduated from medical school at the National University of Singapore (NUS) in 1998 and subsequently completed her ophthalmological training in Singapore in 2007. Her subspecialty fellowship training in the Department of Ocular immunology and inflammation at the Singapore National Eye Center was completed in 2009.

She was awarded a 2-year HMDP fellowship award in 2009 to further her training in uveitis and ophthalmic pathology at the Doheny Eye Institute, Los Angeles, USA and at the Institute of Ophthalmology, University College London and Moorfields Eye Hospital, London, UK.

Her main interests are in ophthalmic pathology and retinal immunobiology research.

She was awarded the ARVO Basic Science award from the Doheny Eye Institute in 2010 for her research on Neuroglobin retinal neuroprotection.

Dr Chan also practices Ophthalmic Pathology in collaboration with the Department of Histopathology at Singapore General Hospital.

Other Concurrent Positions

  • Senior Consultant, Singapore National Eye Centre

Research Interests

CMV keratitis in recurrent graft failure, Neuroglobin neuroprotection in Ophthalmological disorders (retinal ischemia, glaucoma), Animal models of glaucoma, Ophthalmic pathology.

Education

  • 1998
  • National University of Singapore, Bachelor of Medicine, Bachelor of Surgery
  • 2003
  • National University of Singapore, Master of Medicine
  • 2003
  • Royal College of Surgeons, Edinburgh, Member, Royal Coll of Surgeons
  • 2007
  • Royal College of Surgeons, Edinburgh, Member, Fell, Roy Coll of Surg, Edinburgh
  • 2007
  • Academy of Medicine, Fellow Academy of Medicine of Singapore

    Previous Positions

  • 2017
  • Clinician Scientist, Singapore Eye Research Institute
  • 2016-Present
  • Clinical Director, Ophthalmic Pathology Service, Singapore National Eye Centre
  • 2014-Present
  • Senior Consultant, Singapore National Eye Centre
  • 2014-2017
  • Senior Clinical Investigator, Singapore Eye Research Institute
  • 2013-2015
  • Senior Clinical Lecturer, Yong Loo Lin School of Medicine, National University of Singapore
  • 2011-2013
  • Clinical Investigator, Singapore Eye Research Institute
  • 2009-2014
  • Consultant, Singapore National Eye Centre
  • 2007-2009
  • Associate Consultant, Singapore National Eye Centre
  • 2007-2012
  • Clinical Tutor, Yong Loo Lin School of Medicine, National University of Singapore
  • 1999-2004
  • Medical Officer, Singapore National Eye Centre

    Awards

  • 2016
  • Japan Society of Promotion of Science (JSPS) Ronpaku (Dissertation PhD) Program
  • 2014
  • Transition Award
  • 2011
  • SNEC Fellowship Award in Ophthalmic Pathology
  • 2010
  • Doheny Eye Institute: ARVO Basic Science Award
  • 2009
  • Health Manpower Development Plan

    Selected Publications

    1. Chan AS, Yu D, Rao NA. An Eosinophilic Variant of Wegener’s Granulomatosis Archives of Ophthalmology 2011. (in press)
    2. Chan AS, Sharma OP, Rao NA. Review for Disease of the Year: Immunopathogenesis of Ocular Sarcoidosis. Ocular Immunology & Inflammation 2010 18(3), 143-151.
    3. Anita SY Chan, A Looi, Seah LL, Chee SP, J Rootman. Multifocal venous malformations: Two interesting case presentations. Orbit. 2006 Jun;25(2):133-6.

    Prof CHEE Soon Phaik

    Prof CHEE Soon Phaik

    MBBS, FRCS (G), MMed (Ophth), FRCS (Ed), FRCOphth

    Head, Cataract Research Group
    Co-Head, Ocular Inflammation & Immunology Research Group

    Email: chee.soon.phaik@snec.com.sg

    Dr Chee graduated from the National University of Singapore in 1984 and received her FRCS(G), FRCS(Ed), FRCOphth and MMed(S’pore) in 1990. She was one of the pioneer ophthalmologists of the Singapore National Eye Centre which she joined in February 1991. She did her fellowship training in the both Oculoplastics and Uveitis in 1993 at the Moorfields Eye Hospital, London. On her return, she directed her time and efforts to building up the Ocular Inflammation and Immunology Service in SNEC. She has trained 4 local fellows and 9 international fellows and continues to attract fellows from the Asia-Pacific region and even as far as the Middle-East.

    Dr Chee’s uveitis research interests are mainly in Vogt-Koyanagi Harada Disease, Cytomegalovirus infection in the immunocompetent, dengue maculopathy and endogenous endophthalmitis; and have made significant contributions to the ophthalmic literature. She became a member of the International Uveitis Study Group in 2002 and continues to play an active role organizing symposia in international meetings. She is a member of the VKH International Committee and hosted the 6th VKH 2nd Sarcoidosis international workshop in Singapore in February 2009. In addition, she is a member of both the Clinical Consensus Group for Standardisation of Uveitis Nomenclature, and International Sarcoidosis Workshop. Dr Chee was instrumental in the formation of the Asia Pacific Intraocular Inflammation Study Group in June 2006 of which she is the Secretary General. She organized both the inaugural and second meeting in Singapore. Dr Chee’s other passion is in cataract surgery. She is actively engaged in the evaluation of cutting edge technology intraocular lenses (IOL) and phacoemulsification equipment. She specializes in anterior segment reconstruction and managing complicated cases, such as subluxated cataracts and IOLs. She has been invited to speak on her technique of cataract surgery both in the region and internationally, and has been the director of many cataract teaching courses and performed numerous live surgeries. She has also developed new techniques for managing complicated cataracts and has special interest in developing new surgical instruments.

    In addition to clinical work and research, Dr Chee is a keen teacher and received the Best Teacher award by SNEC in 2000 and the American Academy of Ophthalmology Achievement award 2007. She is also an Asia Pacific Association of Cataract and Refractive Surgery (APACRS) Certified Educator (A.C.E), recognized for her contribution in teaching cataract surgery in the region. She has over 150 peer review publications, co-authored 3 textbooks and contributed several book chapters.

    Other concurrent positions

    • Senior Consultant, Oculoplastic/Lacrimal/Orbital Service, Singapore National Eye Centre
    • Associate Professor, Ophthalmology Department, National University of Singapore
    • Professor, Duke-National University of Singapore Graduate Medical School

    Research Interests

    Ocular Inflammation Uveitis

    Education

  • 1989
  • M.B.B.S. National University of Singapore
  • 1989
  • FRCS(G) Fellow of the Royal College of Physicians and Surgeons, Glasgow
  • 1989
  • FRCOphth Fellow of the College of Ophthalmologists (U.K.)
  • 1989
  • MMed National University of Singapore
  • 1989
  • FRCS(Edin) Fellow of the Royal College of Surgeons of Edinburgh

    Previous Positions

    • 1991 Registrar, Singapore National Eye Centre
    • 1992 Senior Registrar, Singapore National Eye Centre
    • 1995 Consultant, Uveitis Service, Singapore National Eye Centre
    • 1999 Mentor for Advanced Trainees in Ophthalmology, National University of Singapore
    • 1999 Senior Consultant, Singapore National Eye Centre
    • 1989 Head, Uveitis Service, Singapore National Eye Centre
    • 2009 Clinical Senior Lecturer, Faculty of Medicine, National University of Singapore, Yong Loo Lin School of Medicine
    • 2010 Co-Head, Training and Education, Singapore National Eye Centre
    • 2000 Senior Advisor, Training and Education, Singapore National Eye Centre

    Awards

    Teaching

  • 2000
  • Best Teacher Award. SNEC
  • 2005
  • APACRS Certified Educator (A.C.E). 18th APACRS Annual Meeting, Beijing China

    Others

  • 2001
  • The Eye Institute-Pharmacia Research Prize for Outstanding Original Paper
  • 2007
  • American Academy of Ophthalmology Achievement award
  • 2007
  • Best editor/reviewer award, International Ophthalmology (100 Euros)
  • 2009
  • Best editor/reviewer award, International Ophthalmology (100 Euros)
  • 2012
  • Outstanding Clinician 2011 awarded by SingHealth
  • 2013
  • Best paper of session award: Intraocular Surgery – Femtosecond Laser. American Society of Cataract and Refractive Surgery
  • 2014
  • Singapore Health Quality Service Award (Gold) awarded by SingHealth

    Ophthalmology & Scientific Involvement

    • Member SERI-EXCO
    • Member International Uveitis Study Group
    • Secretary General Asia Pacific Intraocular Inflammation Study Group
    • Key Opinion Leader Alcon Asia Pacific Advancements in Cataract Technology Group
    • Member Haze Advisory Panel, Ministry of Health
    • Member Strategic Planning Committee, SNEC
    • Member Infection Control Committee, SNEC
    • Section Chair Uveitis Curriculum, International Council of Ophthalmology (ICO)
    • International Council Member IOIS International Council
    • President Asia-Pacific Intraocular Inflammation Study Group (APIISG)
    • Member Residency Advisory Committee (RAC) for Ophthalmology, Singapore
    • Member Health Technology Advisory Committee (HTAC), Ministry of Health
    • Head Cataract Research Group, Singapore Eye Research Institute
    • Member Management Committee, Singapore Eye Research Institute
    • Academic Vice-Chair (Clinical & Faculty Management), Academic Clinical Program for Ophthalmology (EYE-ACP)

    Selected publications

    1. Spontaneous resolution of early postoperative intraocular lens opacification in a patient with uveitis. Wong J, Jap A, Chee SP. Eye (Lond). 2011 Dec; 25(12):1661-2. doi: 10.1038/eye.2011.240.
    2. Posterior scleritis in children: clinical features and treatment. Cheung CM, Chee SP. Ophthalmology. 2012 Jan; 119(1):59-65.
    3. Clinical significance of an equivocal interferon γ release assay result. Ang M, Wanling W, Chee SP. Br J Ophthalmol. 2012 Feb; 96(2):284-8. Epub 2011 May 10.
    4. Aqueous cytokine and chemokine analysis in uveitis associated with tuberculosis. Chee SP at el. Mol Vis. 2012; 18:565-7
    5. Chee SP, Jap A. Reply. Am J Ophthalmol. 2012 Aug; 154(2):415-6.
    6. Chee SP. Pseudo anterior capsule barrier for the management of posterior capsule rupture. J Cataract Refract Surg. 2012 Aug;38(8):1309-15.
    7. Jap A, Chee SP. Imaging in the diagnosis and management of vogt-koyanagi-harada disease. Int Ophthalmol Clin. 2012 Fall;52(4):163-72.
    8. Chee SP at el. Aqueous Cytokine Changes Associated with Posner-Schlossman Syndrome with and without Human Cytomegalovirus. PLoS One. 2012;7(9):e44453. doi:10.1371/journal.pone.0044453. Epub 2012 Sep 13.
    9. Chee SP at el. Author reply. Ophthalmology. 2012 Oct;119(10):2199-200. doi:10.1016/j.ophtha.2012.06.036
    10. Risk factors for poor visual outcome following cataract surgery in Vogt-Koyanagi-Harada disease. Quek DT, Jap A, Chee SP. Br J Ophthalmol. 2011 Nov; 95(11):1542-6.

    A/Prof CHENG Ching-Yu

    A/Prof CHENG Ching-Yu

    MD, MPH, PhD (Johns Hopkins)

    Head, Ocular Epidemiology Research Group
    Head, Statistics Support Platform

    Email: cheng.ching.yu@seri.com.sg

    A/Professor Cheng is an epidemiologist and ophthalmologist. He leads epidemiological research of major eye diseases at SERI and heads the Singapore Epidemiology of Eye Diseases (SEED) Program. A/Professor Cheng completed his preventive ophthalmology research fellowship at the Wilmer Eye Institute and attained his PhD in genetic epidemiology at Johns Hopkins University.

    Other concurrent positions

    • Assistant Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine; and Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
    • Adjunct Associate Professor, Centre for Quantitative Medicine, Office of Clinical Sciences Duke-NUS Graduate Medical School, Singapore

    Research Interests

    A/Professor Cheng’s primary research interests are related to the epidemiology and genetics of major eye diseases. His current work involves in a variety of epidemiological, clinical, and image research for glaucoma, and identification of susceptibility genes for complex ocular diseases, such as age-related macular degeneration, myopia and glaucoma, using both genome-wide association approaches and next-generation sequencing technology.

    Education

    • 1995
    MD Kaohsiung Medical University, Taiwan
    • 1997
    MPH Johns Hopkins Bloomberg School of Public Health, USA
    • 2009
    PhD Johns Hopkins University, USA

    Previous Positions

    • 2002-2008
    Lecturer, Department of Ophthalmology, National Yang Ming University School of Medicine, Taipei, Taiwan
    • 2003-2011
    Attending Ophthalmologist, Glaucoma Section, Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    • 2008-2011
    Assistant Professor, Department of Ophthalmology, National Yang Ming University School of Medicine, Taipei, Taiwan

    Awards

    • 2012
    Clinician Scientist Award, National Medical Research Council, Singapore
    • 2012
    NUHS Clinician Scientist Program Award, National University Health System, Singapore

    Ophthalmology & Scientific Involvement

    • Elected Member, Alpha Chapter of the Delta Omega Honor Society in Public Health, USA
    • Member, Editorial Board, Translational Vision Science & Technology
    • Member, Editorial Board, Case Reports in Ophthalmological Medicine
    • Member, Association for Research and Vision in Ophthalmology, USA
    • Member, American Society of Human Genetics, USA
    • Member, Ophthalmological Society of Taiwan, Taiwan
    • Member, Taiwan Agency for Prevention of Blindness, Taiwan

     

    Selected publications (from over 100 peer-reviewed papers)

     

    Clinical and epidemiological papers

    1. Cheng CY, Liu CJ, Chiou HJ, et al. Color Doppler imaging study of retrobulbar hemodynamics in chronic angle-closure glaucoma. Ophthalmology 2001;108:1445-51.
    2. Cheng CY, Yen MY, Chen SJ, et al. Visual acuity and contrast sensitivity in different types of posterior capsule opacification. Journal of Cataract & Refractive Surgery 2001;27:1055-60.
    3. Cheng CY, Hsu WM, Liu JH, et al. Refractive errors in an elderly Chinese population in Taiwan: the Shihpai Eye Study. Investigate Ophthalmology & Visual Science 2003;44:4630-8.
    4. Cheng CY, Yen MY, Lin HY, et al. Association of ocular dominance and anisometropic myopia. Investigate Ophthalmology & Visual Science 2004;45:2856-60.
    5. Lin HY, Hsu WM, Chou P, …, Cheng CY. Intraocular pressure measured with a noncontact tonometer in an elderly Chinese population: the Shihpai Eye Study. Archives of Ophthalmology 2005;123:381-6.
    6. Tsai HY, Liu CJ, Cheng CY. Combined trabeculectomy and cataract extraction versus trabeculectomy alone in primary angle-closure glaucoma. British Journal of Ophthalmology 2009;93:943-8.
    7. Lee PJ, Liu CJ, Wojciechowski R, …, Cheng CY. Structure-function correlations using scanning laser polarimetry in primary angle-closure glaucoma and primary open-angle glaucoma. American Journal of Ophthalmology 2010;149:817-25.
    8. Liu YC, Chou P, Wojciechowski R, …, Cheng CY. Power vector analysis of refractive, corneal and internal astigmatism in an elderly Chinese population: the Shihpai Eye Study. Investigate Ophthalmology & Visual Science 2011;28;52:9651-7.
    9. Chan EW, Wong TY, Liao J, …, Cheng CY. Branch retinal vein occlusion and optic nerve head topographic parameters: The Singapore Indian Eye Study. British Journal of Ophthalmology 2013;97:611-6.
    10. Tham YC, Cheung CY, Wong TY, …, Cheng CY. Validity of a new optic disc grading software for use in clinical and epidemiological research. Clinical & Experimental Ophthalmology 2013 Apr 9. doi: 10.1111/ceo.12112.

    Genetic papers

    1. Cheng CY, Kao WH, Patterson N, et al. Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. PLoS Genetics 2009;5(5):e1000490.
    2. Cheng CY, Reich D, Coresh J, et al. Admixture mapping of obesity-related traits in African Americans: the Atherosclerosis Risk in Communities (ARIC) Study. Obesity 2010;18:563-72.
    3. Cheng CY, Reich D, Wong TY, et al. Admixture mapping scans identify a locus affecting retinal vascular caliber in hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) Study. PLoS Genetics 2010;15;6(4):e1000908.
    4. Cheng CY, Reich D, Haiman CA, et al. African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts. PLoS One 2012;7(3):e32840.
    5. The AMD Gene Consortium. Seven new loci associated with age-related macular degeneration. Nature Genetics 2013;45:433-9.
    6. Verhoeven VJ, Hysi PG, Wojciechowski R, …, Cheng CY, et al. Genome-wide meta-analyses of multi-ethnic cohorts identify multiple new susceptibility loci for refractive error and myopia. Nature Genetics 2013;45:314-8.
    7. Cheng CY, Schache M, Ikram MK, et al. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. American Journal of Human Genetics 2013 August.

    A/Prof Gemmy CHEUNG

    A/Prof Gemmy CHEUNG

    MBBS(Lond), FRCOphth(UK)

    Head, Retina Research Group

    Email: gemmy.cheung.c.m@snec.com.sg

    Dr Gemmy Cheung is a retinal specialist with interest in age-related macular degeneration, diabetic retinopathy and myopia. She joined the Singapore Eye Research Institute after completing her specialist training in the United Kingdom in 2007.

    Other concurrent positions

    • Senior Consultant, Vitreo-Retinal Service, Singapore National Eye Centre
    • Adjunct Assistant Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
    • Adjunct Assistant Professor, Duke-NUS Graduate Medical School, Singapore

     

    Research Interests

    Imaging and treatment of retinal disorders including age-related macular degeneration, idiopathic polypoidal vasculopathy, diabetic retinopathy and retinal dysfunction in association with ocular inflammation (uveitis)

    Education

    • 2006
    F.R.C.Ophth Royal College of Ophthalmologists (London, UK)
    • 2000
    M.R.C.Ophth Royal College of Ophthalmologists (London, UK)
    • 1997
    M.B.B.S. University of London, UK

    Previous Positions

    • 2008
    Consultant, Vitreo-retina Service, Singapore National Eye Centre
    • 2007
    Associate consultant, Vitreo-retina Service, Singapore National Eye Centre

    Awards

    • 2013
    Asia Pacific Academy of Ophthalmology Outstanding Service in Prevention of Blindness Award
    • 2012
    Bayer Global Ophthalmology Research Award
    • 2011
    Duke-NUS Khoo clinical Scholar Program
    • 2010
    SingHealth Quality Service Silver Award
    • 2009
    Clinician Investigator Award (Singapore National Eye Centre)
    • 2005
    Midland Ophthalmology Society Junior Ophthalmologist Prize
    • 2003
    Roper-Hall Medal (Birmingham & Midland Eye Centre, UK)
    • 2000
    Elizabeth Hunt Medal (Royal College of Ophthalmologists, London

    Ophthalmology & Scientific Involvement

    • Member, Macula Society, USA
    • Member of American Society of Retina Specialists
    • Member of International Society for Clinical Electrophysiology of Vision
    • Member, Singapore Society of Ophthalmology, Singapore

     

    Selected publications

    1. Cheung CMG, Loh BK, Li X, Mathur R, et al. Choroidal thickness and risk characteristics of eyes with myopic choroidal neovascularisation. Acta Ophthalmol 2013 (in press)
    2. Cheung CMG, Li X, Cheng CY, et al. Prevalence and risk factors for age-related macular degeneration in Indians: A comparative study in Singapore and India. Am J Ophthalmol 2013 [Epub ahead of print])
    3. Cheung CM, Yeo I, Li X, Mathur R, et al. Argon Laser with and without Anti-Vascular Endothelial Growth Factor Therapy for Extrafoveal Polypoidal Choroidal Vasculopathy. Am J Ophthalmol 2013 Feb;155(2):295-304.
    4. Cheung CM, Bhargava M, Xiang L, Mathur R, Mun CC, Wong D, Wong TY. Six-month visual prognosis in eyes with submacular hemorrhage secondary to age-related macular degeneration or polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol 2013 Jan;251(1):19-25
    5. Neelam K, Cheung CM, Ohno-Matsui K, Lai TY, Wong TY. Choroidal neovascularization in pathological myopia. Pro Retin Eye Res. 2012 Sep;31(5):495-525.
    6. Cheung CM, Vania M, Ang M, Li J, Chee SP. Comparison of Aqueous Cytokine and Chemokine levels in diabetic patients with and without retinopathy. Mol Vis. 2012; 18:830-7.
    7. Cheung CM, Wong TY. Anti-VEGF Debate: Limitation in Asia. New Eng J Med 2011;365:2237.
    8. Cheung CM, Tai ES, Kawasaki R, Tay WT, Lee JL, Hamzah H, Wong TY. Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort. Arch Ophthalmol 2012 Apr;130(4):480-6.
    9. Lim LS, Cheung CM, Mitchell P, Wong TY. Emerging evidence concerning systemic safety of anti-VEGF agents-should ophthalmologists be concerned? Am J Ophthalmol 2011;152:329-31.
    10. Cheung CM, Cheung CY, Yang EL, Mitchell P, Wang JJ, Wong TY. Retinal Arteriolar Wall Signs and Early Age-Related Macular Degeneration: The Singapore Malay Eye Study. Am J Ophthalmol 2011; 152: 108-113.

    Dr Danny CHEUNG

    Dr Danny CHEUNG

    MBBS, FRANZCO (Aust)

    Clinician Scientist

    Email: cheung.ning@singhealth.com.sg

    Dr Cheung is currently an Associate Consultant Vitreo-Retinal Surgeon managing both medical and surgical retinal conditions at the Singapore National Eye Centre. He is also an Assistant Professor of Ophthalmology at the Duke-NUS Medical School and a Clinician-Scientist at the Singapore Eye Research Institute.

    Dr Cheung completed his undergraduate Medical Degrees from the University of Melbourne, Australia in 2004. There, he also subsequently obtained his postgraduate degree for Doctor of Medicine (Ophthalmology). Dr Cheung was trained as a General Ophthalmologist at the Royal Victorian Eye and Ear Hospital in Melbourne, and received his Australian Ophthalmology Specialist qualification in 2013. In addition, he completed 4 years of subspecialty fellowship training in Vitreo-Retina, including 2 years in Hong Kong, under the supervision of Professor David Wong, and 2 years at the Singapore National Eye Centre.

    Furthermore, Dr Cheung has strong research interest and excellent academic track record in the fields of ophthalmic epidemiology, retinal imaging, diabetic retinopathy and other retinal diseases. He has published over 100 scientific papers and several book chapters. These include articles in prestigious high-impact journals such as the Lancet, British Medical Journal, Diabetes Care, Brain, Annals of Neurology, and Progress in Retinal and Eye Research. His publications are well cited, with a personal H-index of 36. He is currently a leading investigator for a number of eye studies in Singapore, including a clinical trial on neuroprotective therapy for retinal detachment, as well as clinical and laboratory studies on novel therapeutic targets for common retinal diseases such as diabetic retinopathy, age-related macular degeneration and retinal vein occlusion. He is also developing new surgical instruments to improve surgery for retinal detachment. His research work has received national and international recognitions with several awards, such as the Australian Society for Medical Research High Commendation, Bayer’s Global Ophthalmology Award, Diabetes Research Innovation Award, and SingHealth Outstanding Research Award.

    As a surgeon-scientist, Dr Cheung values quality in clinical patient care, as well as education and research. He cherishes his time with patients and provides them patient-centered eye care based on the best available scientific evidence. He also devotes time and passion in conducting translational research that aims to bring new scientific discoveries to clinical application to improve treatment and outcome of eye diseases.

    Other Concurrent Positions

    • Associate Consultant, Singapore National Eye Centre

    Research Interests

    Ocular epidemiology, Medical and surgical vitreoretinal diseases, Retinal vessel analysis

    Education

  • 2004
  • University of Melbourne, Australia, MBBS; BMedSci
  • 2015
  • University of Melbourne, Australia, MD (Ophthalmology)

    Previous Positions

  • 2014-Present
  • Associate Consultant, Singapore National Eye Centre
  • 2011-2013
  • Clinical Investigator, Singapore Eye Research Institute
  • 2013-2014
  • Clinical Assistant Professor of Ophthalmology, The University of Hong Kong Queen Mary Hospital
  • 2012-2013
  • Assistant Professor, The Chinese University of Hong Kong, Hong Kong Eye Hospital
  • 2008-2012
  • Ophthalmology Registrar, Royal Victorian Eye and Ear Hospital
  • 2005-2007
  • Hospital Medical Officer, Melbourne Health (Royal Melbourne and Western Hopsitals)

    Awards

  • 2012
  • Bayer’s Global Ophthalmology Award (Clinical Training)
  • 2012
  • Royal Australia and New Zealand College of Ophthalmology Scholarship
  • 2011
  • Australian Society for Medical Research – High Commendation
  • 2010
  • Progress in Retinal and Eye Research – Top Cited Article 2008-2010
  • 2010
  • Pfizer Cardiovascular Travel Grant
  • 2010
  • Translational Clinical Research in Major Eye Disease Fellowship Grant
  • 2009
  • Diabetes Research Innovation Award
  • 2008
  • Heart Foundation Travel Grant
  • 2007
  • American Academy of Ophthalmology Best Poster Award
  • 2007
  • Juvenile Diabetes Research Foundation Travel Award
  • 2007
  • Most Creative Paper Award – Multi-Ethnic Study of Atherosclerosis
  • 2007
  • Association for Research of Vision and Ophthalmology Travel Fellowship
  • 2007
  • Hugh Noel Puckle Scholarship
  • 2006
  • Centre for Eye Research Travel Award

    Selected Publications

    1. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376:124-36.
    2. Cheung N, Lam DS, Wong TY. Anti-vascular endothelial-growth-factor therapy for eye diseases. British Medical Journal. 2012;344:e2970.
    3. Cheung N, Wong TY. Fenofibrate and diabetic retinopathy. Lancet. 2008;371:721-2.
    4. Cheung N, Wong TY. Diabetic retinopathy and systemic vascular complications. Progress in Retinal and Eye Research. 2008;27:161-76.
    5. Cheung N, et al. Anti-vascular endothelial growth factor for diabetic retinopathy: overview of clinical efficacy and evolving applications. Diabetes Care. 2014;37:900-5.

    Adj. A/Prof Audrey CHIA

    Adj. A/Prof Audrey CHIA

    MBBS (Hons), FRANZCO, MBA, PhD

    Co-Head, Myopia Research Group

    Email: audrey.chia.w.l@snec.com.sg

    Dr Audrey Chia graduated from the University of Sydney (1992), and did her ophthalmology training at the Sydney Eye Hospital (1996-1999). She returned to Singapore in 2000 and worked as an Ophthalmology Registrar at the Singapore National Eye Center (2000-1) before doing a Paediatric Ophthalmology fellowship at the Great Ormond Street Hospital for Children in London (mid 2001-2). She later spent 3 months as an Observor at the Children’s Hospital of Philadelphia before returning to Singapore. She has been based at the Singapore National Eye Center ever since.

    Besides being actively involved in clinical care, Dr Chia’s research interests include strabismus, amblyopia, retinopathy of prematurity, medical and non-medical control of myopia.

    Dr Chia also helps manage the SNEC-SERI Visual ElectroDiagnostic Laboratory, and is a member of the International Society of Electrophysiology Vision (ISCEV). Her interests here include functional changes in myopia and amblyopia, retinal dystrophy and drug-related toxicities.

    Other concurrent positions

    • Senior Consultant, Paediatric and Strabismus Service, Singapore National Eye Centre & KK Women and Children’s Hospital
    • Senior Consultant-in-charge, Visual Electrophysiology, SNEC-SERI Visual Electrodiagnostic Laboratory
    • Core Faculty, Ophthalmology, Singhealth Residency Program
    • National examiner for Ophthalmology, Postgraduate Medical Examinations, Singapore
    • Adjunct Associate Professor, Duke-NUS medical graduate school
    • Clinical lecturer, Yong Loo Lin School of Medicine, National University Singapore

    Research Interests

    Myopia, strabismus, retinopathy of prematurity, amblyopia and visual electrophysiology.

    Education

  • 1992
  • MBBS (Hons) University of Sydney
  • 2000
  • FRANZCO Royal Australian College of Ophthalmologists
  • 2008
  • MBA University of Southern Queensland
  • 2013
  • PhD National University of Singapore

    Previous Positions

  • 2002
  • Observor, Oculoplastics Department, Children’s Hospital of Philadelphia and Scheie Eye Institute, USA
  • 2001
  • Paediatric Ophthalmology Fellow, Great Ormond Street Hospital for Children, London, UK
  • 2000
  • Ophthalmology Registrar, Singapore National Eye Center
  • 1996-99
  • Ophthalmology Registrar, Sydney Eye Hospital, Australia

    Awards

  • 2013
  • Service from the Heart Award 2013, KKH
  • 2012
  • Singhealth Residency: Outstanding Faculty Award, Academic Yr 2012/2013
  • 2013
  • Singapore Health Quality Service (SHQS) Silver Award 2013
  • 2011
  • Singhealth Residency: Innovative Educator Award, Academic Yr 2011/2012
  • 2010
  • Service Star Award, SNEC

    Ophthalmology & Scientific Involvement

    • Member, International Society of Clinical Electrophysiology for Vision (ISCEV)

    Selected publications

    1. Sim B, Yap GH, Chia A. Functional and Psychosocial Impact of Strabismus in Asian Children. J AAPOS 2014;18(2):178-82.
    2. Chia A, Li W, Chua WH, Goon YY, Fong A, Tan D. Changes after cessation of Atropine: ATOM2. Am J Ophthalmol 2014; 157(2): 451-7.
    3. Chia A, Lin XY, Mohamed D et al. Risk factors for Strabismus and Amblyopia in young Singapore Chinese children. Ophthalmic Epidemiology 2013; 20(3):138-47.
    4. Chia A, Chua WH, Cheung YB, Wong WL, Lingham A, Fong A, Tan D. Atropine for the treatment of Childhood myopia: safety and efficacy of 0.5%, 0.1% and 0.01% dosages (ATOM2). Ophthalmology 2012; 119(2): 347-54.
    5. Chia A, Dirani M, Chan YH et al. Prevalence of Amblyopia and Strabismus in Young Singaporean children. Invest Ophthalmol Vis Sci. 2010; 51(7):3411-7.
    6. Chia A, Guzzard G, Tong L, Zhang X, Sim EL, Fong A, Saw SM. Red-Green Colour Blindness amongst Singaporean Schoolchildren. Clinical & Exp Ophthal 2008; 36: 464-7.
    7. Chia A, Roy L, Seenyen L. Comitant Horizontal Strabismus Patterns in Singapore: An Asian persceptive. British J Ophthal 2007; 91(10): 1337-40.
    8. Chia A, Jaurigue A, Gazzard G, Wang Y, Tan D, Stone RA, Saw SM. Dominance, laterality and Refraction in Singaporean school children. IOVS 2007; 48(8):3533-6.
    9. Chia A, Luu CD, Mathur R, Cheng B, Chee SP. Electrophysiological findings in Dengue related Maculopathy. Arch Ophthalmol. 2006; 124(10):1421-6.
    10. Chia A, Seenyen L, Quah BL. A retrospective review of 287 consecutive children presenting with Intermittent Exotropia in Singapore. JAAPOS 2005; 9: 257-63.

    Dr Jacqueline CHUA

    Dr Jacqueline CHUA

    BOptom, PhD, FAAO

    Senior Clinical Research Fellow

    Email: jacqueline.chua.y.m@seri.com.sg

    Dr Jacqueline Chua is Senior Clinical Research Fellow at Singapore Eye Research Institute and also a practicing Optometrist at the Singapore National Eye Center. Dr Chua graduated from the University of Melbourne with a Bachelor of Optometry in 2001 and from the University of Auckland with a PhD in 2008. Following completion of her doctorate, she undertook five years in optometric academia. She has been awarded clinical fellowship from the American Academy of Optometry (2015).

    She possesses demonstrated abilities to undertake research across three domains: pre-clinical science (doctorate in an animal model of retinal degeneration), clinical research (principal investigator for investigator-initiated trials) and clinical translation (evidence-based practice).

    Other concurrent positions

    • Adjunct Instructor, Graduate Medical School Duke-NUS

     

    Research Interests

    Ocular Imaging, Primary eye care, Epidemiology

    Education

    • 2015
    FAAO American Academy of Optometry
    • 2008
    PhD University of Auckland, New Zealand
    • 2001
    Bachelor of Optometry University of Melbourne, Australia

    Previous Positions

    • 2009 – 2012
    Lecturer, Optometry degree course for the University of Manchester in Singapore Polytechnic
    • 2008
    Fellow, Department of Optometry and Vision Science, University of Auckland, New Zealand

    Awards

    • 2003
    New Zealand Health Research Council and Retina Australia Scholarship for PhD
    • 2008
    New Zealand save sight society grant for postdoctoral research
    • 2008
    Won the best light microscopy winner in 2008 imaging competition by the School of Medical Sciences, University of Auckland, New Zealand

    Ophthalmology & Scientific Involvement

          • Member, The Association for Research in Vision and Ophthalmology (ARVO), USA
          • Member, American Academy of Optometry, USA
          • Elected Member, Ministry of Health Clinical Optometry Practice Advisory Panel, Singapore
          • Elected Member, Ministry of Health Optometrists and Opticians Board Accreditation Committee, Singapore
          • Elected Lead (Eye), Singhealth Allied Health Research Committee, Singapore

    Selected publications

              1. Chua J, Nongpiur ME, Zhao W, et al. Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults. Ophthalmology. 2017 Sep;124(9):1271-1279. doi: 10.1016/j.ophtha.2017.03.055
              2. Chua J, Lim B, Fenwick EK, et al. Prevalence, Risk Factors, and Impact of Undiagnosed Visually Significant Cataract: The Singapore Epidemiology of Eye Diseases Study PLoS One. 2017 Jan 27;12(1):e0170804
              3. Chua J, Wong TY. Myopia: the silent epidemic that should not be ignored. JAMA Ophthalmol. 2016 Aug
              4. Chua J, Thakku SG, Tun TA, et al. Iris Crypts Influence Dynamic Changes of Iris Volume. Ophthalmology. 2016 Aug 9. pii: S0161-6420(16)30502-4
              5. Chua J, Koh JY, Tan AG, et al. Ancestry, Socioeconomic Status, and Age-Related Cataract in Asians: The Singapore Epidemiology of Eye Diseases Study. Ophthalmology. 2015 Nov;122(11):2169-78
              6. Chua J, Baskaran M, Ong PG, et al. Prevalence, Risk Factors, and Visual Features of Undiagnosed Glaucoma: The Singapore Epidemiology of Eye Diseases Study. JAMA Ophthalmol. 2015 Aug;133(8):938-46.
              7. Chua J, Tham YC, Liao J, et al. Ethnic differences of intraocular pressure and central corneal thickness: the Singapore Epidemiology of Eye Diseases study. Ophthalmology. 2014 Oct;121(10):2013-22

    Prof Wallace Steward FOULDS

    Prof Wallace Steward FOULDS

    CBE, MD, ChM, FRCS (Eng), FRCS (Glas), DO, Hon. FRCOphth, Hon. DSc (Strathclyde), Hon. FRANZCO, Hon. FCMSA. Hon FRSM

    Honorary Senior Scientific Advisor

    Email: wallace.steward.foulds@seri.com.sg

    Prof Wallace Foulds is well known to Ophthalmologists in the Asia Pacific. He is Founder President of the Royal College of Ophthalmologists and Co-Founder of the Singapore Eye Research Institute.

    In 1964 Wallace Foulds was appointed to the Tennent Chair of Ophthalmology in the University of Glasgow to head a clinical department which had its origins in the appointment in the early 19th century of William Mackenzie as first Lecturer in Ophthalmology in the University of Glasgow. Later incumbents of the Chair included Arthur Ballantyne who, with Isaac Michaelson, were distinguished for original investigative work related to the retina and its circulation.

    Other concurrent positions

    • Emeritus Professor of Ophthalmology, University of Glasgow.
    • Consultant in Medico-legal Practice

     

    Research Interests

    Posterior segment ocular disorders, (Diabetic Retinopathy, ROP, ARMD), cell and molecular biology of retinal hypoxia/ischemia.. Etiology and management of childhood myopia. Drug delivery to the ocular posterior segment. Diagnostic imaging. Biology of vitreous. Ocular oncology.

    Education

    • 1946
    MB ChB University of Glasgow
    • 1952
    DO Royal College of Physicians & Royal College of Surgeons (Eng)
    • 1953
    FRCS Royal College Surgeons (Eng)
    • 1958
    MD (Commend) University of Glasgow
    • 1964
    ChM (Hons) University of Glasgow
    • 1976
    FRCS Royal College of Physicians & Surgeons (Glasg)
    • 1988
    FRCOphth) Royal College of Ophthalmologists

    Previous Positions

    • 1951
    Registrar Moorfields Eye Hospital London
    • 1953
    Senior Registrar University College Hospital London
    Research Assistant, Institute of Ophthalmology, London University
    • 1958
    Consultant Ophthalmologist Addenbrookes Hospital Cambridge, Honorary Lecturer Cambridge University
    Research Fellow (Senior Lecturer): Department of Experimental Ophthalmology(Institute of Ophthalmology) London University
    • 1990
    Adviser in Research – Singapore National Eye Centre and Singapore Eye
    Research Institute, Visiting Professor, National University of Singapore
    • 2000
    Co-Director, Singapore Eye Research Institute
    • 2002
    Visiting Professor, Department of Ophthalmology, National University of Singapore

    Awards

    • 1970
    Owen Aves Medal, Yorkshire Optical Society
    • 1972
    Bronze Medal, University of Helsinki, Finland
    • 1975
    Doyne Medal, Oxford Ophthalmological Congress
    • 1979
    Edridge Green Award, Royal College of Surgeons of England
    Palmer Dutt Medal, West Bengal Ophthalmological Society, India
    • 1981
    Mackenzie Medal, Royal College of Physicians and Surgeons of Glasgow
    • 1982
    Bjerrum Award, Danish Ophthalmological Society, Copenhagen, Denmark
    • 1986
    Bowman Medal, Ophthalmological Society of the United Kingdom
    • 1988
    Awarded CBE by Her Majesty Queen Elizabeth
    • 1988
    Richardson-Cross Medal South Western Ophthalmological Society
    • 1997
    International Gold Medal Singapore National Eye Centre
    • 1999
    Den Ernst Custodis Pries Die Retinologische Gesellschaft Berlin Germany
    • 2002
    ASM Lim Gold Medal Singapore National Eye Centre
    • 2003
    The Paul Kaiser International Award in Retina Research, American Retina Research Foundation, Houston Texas USA

    Ophthalmology & Scientific Involvement

    Honorary Degrees and Diplomas

    • DSc, University of Strathclyde
    • Honorary Fellowship Faculty of Ophthalmologists (UK)
    • Honorary Fellowship Royal Australian and New Zealand College of Opthalmologists
    • Honorary Fellowship Royal College of Ophthalmologists
    • Honorary Fellowship College of Surgeons of South Africa
    • Honorary Fellowship Royal Society of Medicine
    • Honorary Fellowship The Medical & Dental Defence Union for Scotland
    • Honorary Fellowship The Medical & Dental Defence Union for Scotland
    • Ex-Chairman Association for Eye Research
    • Honorary Member European Association for vision and Eye Research (EVER)

     

    Membership of Editorial Boards (Past and Present)

    • Transactions of the Ophthalmological Societies of the United Kingdom, Eye
    • British Journal of Ophthalmology (Assistant Editor), International Ophthalmology
    • Journal of Neuro-Ophthalmology, European Journal of Ophthalmology
    • Journal of Clinical Neuro-Ophthalmology, Hong Kong Journal of Ophthalmology
    • Asia Pacific Journal of Ophthalmology, Asia-Pacific Biotech News

     

    Scientific Paper reviewer

    Investigative Ophthalmology and Visual Science, Progress in Retina and Eye Research, British Journal of Ophthalmology, Eye, Journal of Hypertension, etc

    Selected publications: (from 215 scientific papers and 31 book chapters)

    1. Kaur C, Sivakumar V, Robinson R, Foulds WS, Luu CD, Ling EA. Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats. J Pineal Res. 2013 Mar;54(2):190-206.
    2. Sivakumar V, Foulds WS, Luu CD, Ling EA, Kaur C. Hypoxia-induced retinal ganglion cell damage through activation of AMPA receptors and the neuroprotective effects of DNQX. Exp Eye Res. 2013 Apr;109:83-97.
    3. Kaur C, Sivakumar V, Foulds WS, Luu CD, Ling EA. Hypoxia-induced activation of N-methyl-D-aspartate receptors causes retinal ganglion cell death in the neonatal retina. J Neuropathol Exp Neurol. 2012 Apr;71(4):330-47.
    4. Luu CD, Foulds WS, Kaur C. Electrophysiological findings in a porcine model of selective retinal capillary closure. Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2218-25.
    5. Sivakumar V, Foulds WS, Luu CD, Ling EA, Kaur C. Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. J Pathol. 2011 Jun;224(2):245-60.
    6. Foulds WS, Kek WK, Luu CD, Song IC, Kaur C. A porcine model of selective retinal capillary closure induced by embolization with fluorescent microspheres. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6700-9.
    7. Kek WK, Foulds WS, McConnell G, Wright AJ, Girkin JM, Wilson CG. Two-photon fluorescence excitation microscopy to assess transscleral diffusional pathways in an isolated perfused bovine eye model. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5182-9.
    8. Foulds WS, Kaur C, Luu CD, Kek WK. A role for photoreceptors in retinal oedema and angiogenesis: an additional explanation for laser treatment? Eye (Lond). 2010 May;24(5):918-26.
    9. Kaur C, Sivakumar V, Foulds WS, Luu CD, Ling EA. Cellular and vascular changes in the retina of neonatal rats after an acute exposure to hypoxia. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5364-74.
    10. Kaur C, Foulds WS, Ling EA. Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog Retin Eye Res. 2008 Nov;27(6):622-47.

    Dr Michaël JA GIRARD

    Dr Michaël JA GIRARD

    B.Sc., M.Sc., Ph.D

    Co-Head, Bioengineering & Devices Research Group

    Email: mgirard@nus.edu.sg

    Dr Michael Girard is a scientific consultant at SERI and Co-Head (together with Dr Shamira Perera) of the Biomedical Engineering and Devices initiative. He is also an Assistant Professor in the Department of Biomedical Engineering at the National University of Singapore.

     

    Dr Girard received his engineering diploma (equivalent to a MSc) in Mechanical Engineering from the Ecole Polytechnique Universitaire de Lyon, France in 2003. He was awarded his PhD from the Department of Biomedical Engineering at Tulane University, New Orleans, USA, in January of 2009. Subsequently, Dr Girard pursued his postdoctoral work in the Department of Bioengineering at Imperial College London, UK. In September of 2010, Dr Girard was awarded a highly competitive and prestigious Imperial College Junior Research Fellowship to pursue his research. Throughout his training, Dr Girard has gained expertise in experimental, theoretical, and computational soft tissue biomechanics, which he has utilised to pose and answer questions of high clinical relevance in the field of ophthalmology.

     

    Dr Girard’s current research program aims to develop state-of-the-art engineering tools for the diagnosis and treatment of biomechanically-related pathologies.

     

    Other concurrent positions

    • Assistant Professor, Department of Biomedical Engineering, National University of Singapore

     

    Research Interests

    • Diagnosis and therapy for biomechanically-related disorders
    • Translational biomechanics
    • Ophthalmic engineering
    • Experimental and computational soft tissue biomechanics
    • Optical coherence tomography theory, developments and applications
    • Optical coherence elastography and digital image processing
    • Ophthalmic devices

     

    Education

    • 2009 PhD Tulane University, New Orleans, Louisiana, USA.
    • 2003 BSc/MSc Ecole Polytechnique Universitaire de Lyon, France

     

    Previous Positions

    2010-2012: Imperial College Junior Research Fellowship, Department of Bioengineering, Imperial College London, UK

     

    2009-2010: Research Associate, Department of Bioengineering, Imperial College London, UK

     

    2003-2009: Research Assistant, Department of Biomedical Engineering, Tulane University, New Orleans, USA; Louisiana State University Eye Center, New Orleans, USA; Devers Eye Institute, Legacy Health, Portland, USA

     

    Awards

    • 2014 NUS Young Investigator Award, National University of Singapore
    • 2013 Travel Grant Award, Association for Research in Vision and Ophthalmology (ARVO; Senior Author)
    • 2012 Xtreme Research Award, Heidelberg Engineering (major company in OCT manufacturing).
    • 2012 Travel Grant Award, Association for Research in Vision and Ophthalmology (ARVO; First Author)
    • 2012 Travel Grant Award, Association for Research in Vision and Ophthalmology (ARVO; Senior Author)
    • 2010 Imperial College Junior Research Fellowship, Imperial College London
    • 2010 Travel Fellowship, International Society for Eye Research (ISER)

     

    Ophthalmology & Scientific Involvement

    • Co-Chair NUS Biomedical Engineering Industry Alliance
    • Member Association for Research in Vision and Ophthalmology
    • Member International Society for Eye Research
    • Member European Mechanics Society
    • Member American Society of Mechanical Engineers

     

    Selected publications:

    1. Girard MJA, Dupps WJ, Mani B, Scarcelli G, Yun SH, Quigley HA, Sigal IA, Strouthidis NG. Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects. Current Eye Research. 2014; In Press.
    2. Girard MJA, Strouthidis NG, Desjardins A, Mari JM, Ethier CR. In Vivo Optic nerve Head Biomechanics: Performance Testing of a 3D tracking algorithm. Journal of the Royal Society Interface. 2013; 10(87):20130459
    3. Mari JM, Park SC, Strouthids NG, Girard MJA. Enhancement of Lamina Cribrosa Visibility in Optical Coherence Tomography Images Using Adaptive Compensation. Invest Ophthalm and Vis Sci. 2013; 54(3):2238-47
    4. Strouthidis NG, Girard MJA. Altering the way the optic nerve responds to intraocular pressure – a potential approach to glaucoma therapy. Current Opinion in Pharmacology. 2013; 13(1):83-89.
    5. Girard MJA, Strouthidis NG, Ethier CR, Mari JM. Shadow Removal and Contrast Enhancement in Optical Coherence Tomography Images of the Human Optic Nerve Head. Invest Opthalmol and Vis Sci. 2011; 52(10):7738-48.
    6. Girard MJA, Suh J-KF, Bottlang M, Burgoyne CF, Downs JC. Biomechanical Changes in the Sclera of Monkey Eyes Exposed to Chronic IOP Elevations. Invest Ophthalmol and Vis Sci. 2011; 52(8):5656-5669.

    Google Scholar Profile
    http://scholar.google.com/citations?user=pXpHy7gAAAAJ

    In vivo Biomechanics Laboratory Website

    http://www.bioeng.nus.edu.sg/ivb

    Dr HLA Myint Htoon

    Dr HLA Myint Htoon

    Senior Research Fellow

    Email: hla.myint.htoon@seri.com.sg

    Dr Hla Myint Htoon, is a clinical outcomes research scientist His work with SERI entails statistical and health economic evaluation research work for clinical outcomes.

    Other concurrent positions

    • Adjunct Assistant Professor, Centre for Quantitative Medicine, Office of Clinical Sciences, Graduate Medical School Duke-NUS

    Research Interests

    He has keen interest in clinical outcomes research resulting from his PhD study on clinical and health promotion effect outcomes of periodontal health. In 2007, just after acquiring his PhD from NUS he joined Singapore Eye Research Institute. His focus of research work for clinical outcomes is in retrospective and prospective ophthalmology clinical outcomes on therapeutics (medications, surgical treatments, etc.). His experience in clinical outcomes research involves the evaluation of risk factors for Singapore corneal transplant study (survival analyses) and clinical trial 5FU study for Glaucoma patients. He also has clinical outcomes research experience (diagnostics, structural equation modeling, etc.) in the dental field. He is developing a Glaucoma Utility Index for Singapore using discrete choice experiments methodology and also developing a Markov Model for the lifetime management of Primary Angle Closure Glaucoma in Singapore. Dr. Htoon is a co- PI for the Glaucoma Utility Index study in Singapore (HREF grant), and has authored & co-authored over 40 papers.

    Education

  • 1975
  • B.D.S. Institute of Dental Medicine, Yangon, Myanmar
  • 2007
  • Ph.D. Faculty of Dentistry/ National University of Singapore (Preventive Dentistry)

    Previous Positions

  • 1984
  • United Nations Volunteer- Dental Surgeon, Ministry of Health. Cook Islands. South Pacific.
  • 1988
  • Temporary Advisor: WHO, Geneva. Expert Group on Equipment and Materials for Oral Care (EGEMOC) meeting Geneva, Switzerland.
  • 1987
  • Dental/Oral Health Co-ordinator, Thai-Cambodian Border Displaced Persons Camps. NGOs: Catholic Relief Services, USCC/ Catholic Office for Relief and Refugees, Thailand. Funding: United Nations Border Relief Operation.
  • 1993
  • Provincial Dental Officer, Ministry of Health, Mutare, Manicaland, Zimbabwe.

    Awards

    Nil

    Ophthalmology & Scientific Involvement

    • Statistical Advisor: Proceedings of Singapore Health Care (SingHealth Cluster Journal) Editorial Committee.

    Selected publications

    1. Htoon HM, Peng LL, Huak CY. Assessment criteria for compliance with oral hygiene: application of ROC analysis. Oral Health Prev Dent. 2007;5(2):83-8.
    2. Tan DT, Janardhanan P, Zhou H, Chan YH, Htoon HM, Ang LP, Lim LS. Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant Study.Ophthalmology. 2008 Jun;115(6):975-982.e1.
    3. Anshu A, Parthasarathy A, Mehta JS, Htoon HM, Tan DT. Outcomes of therapeutic deep lamellar keratoplasty and penetrating keratoplasty for advanced infectious keratitis: a comparative study. Ophthalmology. 2009 Apr;116(4):615-23
    4. Han DC, Mehta JS, Por YM, Htoon HM, Tan DT. Comparison of Outcomes of Lamellar Keratoplasty and Penetrating Keratoplasty in Keratoconus. Am J Ophthalmol. 2009 Jul 8
    5. Wong TT, Khaw PT, Aung T, Foster PJ, Htoon HM, Oen FT, Gazzard G, Husain R, Devereux JG, Minassian D, Tan SB, Chew PT, Seah SK. The singapore 5-Fluorouracil trabeculectomy study: effects on intraocular pressure control and disease progression at 3 years. Ophthalmology. 2009 Feb;116(2):175-84.
    6. How A, Chua J, Charlton A, Su R, Htoon H, Lim M, Kumar R, Crowston J, Wong T. Combined treatment with Bevacizumab and 5-Fluorouracil attenuates the post-operative scarring response following experimental glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 2009 Sep 24.
    7. Ang M, Htoon HM, Chee SP. Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. Ophthalmology. 2009 Jul;116(7):1391-6
    8. Ang M, Mehta JS, Sng CC, Htoon HM, Tan DT. Indications, outcomes, and risk factors for failure in tectonic keratoplasty. Ophthalmology. 2012 Jul;119(7):1311-9. Epub 2012 Apr 27. PubMed PMID: 22541633.
    9. Wong MH, Husain R, Ang BC, Gazzard G, Foster PJ, Htoon HM, Wong TT, Oen FT,
    10. Khaw PT, Seah SK, Aung T. The singapore 5-Fluorouracil trial: intraocular pressure outcomes at 8 years. Ophthalmology. 2013 Jun;120(6):1127-34. doi: 10.1016/j.ophtha.2012.12.004. Epub 2013 Mar 1.

    Dr Donny HOANG

    Dr Donny HOANG

    B.A., MD, PhD

    Clinician Scientist

    Email: donny.hoang@snec.com.sg

    Dr. Hoang is a clinician scientist, with a clinical practice focusing on surgical retina and the complications of extreme short-sightedness (pathologic myopia) and research interests in novel diagnostics and treatment for vision-threatening forms of short-sightedness. Specifically, his research program employs cutting-edge, non-invasive multimodal imaging to identify patients at greatest risk of vision loss from short-sightedness as well animal studies aimed at discovering novel treatments to stunt short-sightedness and avoid vision-threatening changes, including scleral collagen crosslinking to selectively strengthen areas of the eye wall.

    Dr. Hoang has been awarded over US$2 million in competitive research funding for his work in short-sightedness. He has received numerous awards including Clinician Scientist Career Development Awards from the National Institutes of Health (NIH) and Research to Prevent Blindness (RPB), and recently the 2016 Honor Award from the American Society of Retina Specialists, 2017 Induction into the prestigious Macula Society and the Retina Society. Dr Hoang is a well-published physician scientist with articles in major international ophthalmology journals, including Ophthalmology, IOVS and JAMA Ophthalmology and is a reviewer for 10 of these journals.

    He received his joint M.D. and Ph.D. in Neuroscience and Biophysics from the University of Illinois at Chicago before completing his residency in Ophthalmology at the University of Illinois Eye and Ear Infirmary. He obtained American Board Certification in Ophthalmology in 2011 and completed his fellowship in Vitreo-retinal Surgery at Columbia University Medical Center and Vitreous Retina Macula Consultants of New York (VRMNY) at the Manhattan Eye Ear and Throat Hospital.

    He has been an Assistant Professor at the Department of Ophthalmology, Columbia University since 2012 where he was the Director of the High Myopia Laboratory and ran a Surgical and Medical Retina clinical practice focused on pathologic myopia.

    Other Concurrent Positions

    • Consultant, Surgical Retina Dept, Singapore National Eye Centre
    • Assistant Professor, EYE-ACP, Duke-NUS Graduate Medical School

     

    Research Interests

    Pathological myopia, specifically clinical studies employing multimodal imaging to better assess myopic staphyloma progression as well as pre-clinical studies to halt myopia by strengthening the eye wall.

    Education

    • 1997
    Triple Bachelors (B.A., Hons) Northwestern University, Chicago
    • 2006
    M.D. University of Illinois at Chicago
    • 2006
    Ph.D. (Neuroscience, Biophysics) University of Illinois at Chicago

    Previous Positions

    • 2016-Present
    Clinician Scientist, Singapore Eye Research Institute
    • 2015-2016
    Visiting Clinician Scientist, Singapore National Eye Centre/Singapore Eye Research Institute
    • 2012-2017
    Assistant Professor of Ophthalmology, Columbia University
    • 2010-2012
    Fellowship- Surgical Retina, Columbia University (Stanley Chang)
    • 2010-2012
    Fellowship- Medical Retina, Vitreous, Retina Macula Consultants of New York (VRMNY- Lawrence Yannuzzi)
    • 2010-2012
    Clinical Instructor, Department of Ophthalmology, New York University
    • 2007-2010
    Ophthalmology Residency, Illinois Eye and Ear Infirmary, Chicago
    • 2006-2007
    Internal Medicine, Preliminary Residency, Northwestern University
    • 2004
    Posdoctoral Research Associate, University of Illinois at Chicago

    Awards

    • 2017
    Inductee, The Macula Society
    • 2017
    Inductee, The Retina Society
    • 2016
    Honor Award, American Society of Retina Specialists
    • 2016
    John Cushman Private Grant
    • 2015
    NIH R21, Co-investigator
    • 2014
    NIH/NEI, K08 Clinical Scientist Research Career Development Award
    • 2014
    Joseph Connors Private Grant
    • 2014
    Research to Prevent Blindness Career Development Award
    • 2013
    NIH K12 Clinical Translational Sciences Career Development Award
    • 2010
    Illinois Eye and Ear Infirmary Top Resident Research Award
    • 2006
    Outstanding Thesis Award in the Life Sciences, UIC Graduate College
    • 2005
    Grass Fellowship in the Neurosciences

    Ophthalmology & Scientific Involvement

    • Member, Macula Society
    • Member, Retina Society
    • Member, American Society of Retina Specialists
    • Member, American Association of Ophthalmology
    • Member, Assoc. for Research in Vision and Ophthalmology
    • Member, Asia Pacific Academy of Ophthalmology
    • Member, New York State Ophthalmological Society

     

    Selected Publications

    1. Hoang QV, Chen CL, Garcia-Arumi J, Sherwood PR and Chang S. Radius of curvature changes in spontaneous improvement of foveoschisis in highly myopic eyes. Br J Ophthalmol. 2016 Feb;100(2):222-6.
    2. Balaratnasingam C, Hoang QV, Inoue M, Curcio CA, Yannuzzi NA, Dhrami-Gavazi E, Yannuzzi LA and Freund KB. Clinical Characteristics, Choroidal Neovascularization and Predictors of Visual Outcomes in Acquired Vitelliform Lesions. Am J Ophth. 2016 Dec;172:28-38.
    3. Rohrbach D, Reisner AS, Wen Q, McFadden SA, Silverman RH, Hoang QV, Mamou J, Microstructural assessment of the Guinea pig sclera using quantitative acoustic microscopy. Ultrasonics Symposium, IEEE International. 2016 Sept:18-21.
    4. Jung JJ, Hoang QV, Ridley-Lane ML, Sebrow DB, Dhrami-Gavazi E and Chang S. Long-term Retrospecitve Analysis of Visual Acuity and Optical Coherence Tomographic Changes after Single Versus Double Peeling During Vitrectomy for Macular Epiretinal Membranes. Retina. 2016 Nov;36(11):2101-2109.
    5. Dolz-Marco R, Hoang QV, Gallego-Pinazo R and Chang S. Assessment of the Significance of Cystic Changes after Epiretinal Membrane Surgery with Internal Limiting Membrane Removal. Retina. 2016 Apr;36(4):727-32.
    6. Jung JJ, Hoang QV, Arain MZ and Chang S. Aflibercept Anti-Vascular Endothelial Growth Factor Therapy in Vitrectomized Eyes with Neovascular Age-Related Macular Degeneration. Acta Ophthalmol. 2016 May;94(3):e249-50.
    7. Rohrbach D, Hoang QV, Wen Q, McFadden SA, Silverman RH, Mamou J. Fine-resolution elastic-property maps of myopic sclera by means of acoustic microscopy. Ultrasonics Symposium, IEEE International. 2015 Oct:1- 4.
    8. Freund KB, Hoang QV, Saroj N and Thompson D. Intraocular Pressure in Patients with Neovascular Age-Related Macular Degeneration Receiving Intravitreal Aflibercept or Ranibizumab. Ophthalmology 2015 Sep;122:1802-10.
    9. Sepulveda G, Chang S, Freund KB, Park S and Hoang QV. Late Recurrence of Myopic Foveoschisis After Successful Repair with Primary Vitrectomy and Membrane Peeling. Retina.2014 Sep;34(9):1841-7.
    10. Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, Tsang SH. Gene Therapy in Patient-specific Stem Cell Lines and a Preclinical Model of Retinitis Pigmentosa With Membrane Frizzled-related Protein Defects. Mol Ther. 2014 Sep;22(9):1688-97.
    11. Kim M, Takaoka A, Hoang QV, Trokel SL and Paik DC. Pharmacologicalternatives to riboflavin photochemical corneal cross-linking: a comparison study of cell toxicity thresholds. Invest Ophthalmol Vis Sci. 2014 Apr 10;55(5):3247-57.
    12. Hoang QV, Jung JJ, Mrejen S and Freund KB. Influence of Axial Length and Degree of Injection Reflux on Sustained Intraocular Pressure Elevation Due to Intravitreal Anti-Vascular Endothelial Growth Factor Therapy. Retina. 2014 Mar;34(3):519-24.
    13. Chang S, Gregory-Roberts E, Laud KL, Park S and Hoang QV. Double peeling during vitrectomy for macular pucker: the Charles L. Schepens Lecture. JAMA Ophthalmol. 2013 Apr 1;131(4):525-30.
    14. Warrow D, Hoang QV and Freund KB. Pachychoroid Pigment Epitheliopathy. Retina. 2013 Sep;33(8):1659-72.
    15. Hoang QV, Mendonca LS, DellaTorre KE, Jung JJ, Tsuang AJ and Freund KB. Effect on intraocular pressure in patients receiving unilateral intravitreal anti-vascular endothelial growth factor injections. Ophthalmology. 2012 Feb;119(2):321-6.
    16. Hoang QV, Qian H and Ripps H. Functional Analysis of Hemichannels and Gap-Junctional Channels Formed by Connexins 43 and 46. Molecular Vision. 2010 Jul 15;16:1343-52.

    Dr HOU Aihua

    Dr HOU Aihua

    PhD

    Senior Research Fellow

    Email: hou.aihua@seri.com.sg

    Dr Hou attained her Masters in microbiology at Shandong Unversity, China, completed her PhD and postdoctoral training in epigenetics at Nanyang Technological University, Singapore.

     

    Other concurrent positions

    • Adjunct Instructor, Duke-NUS

     

    Research Interests

    Dr Hou focuses on molecular pathogenesis of human pterygium which is a wing-shaped ocular surface lesion leading to visual disturbances. She is trying to construct a mouse bona fide pterygium model and to test the effect of potential drugs that may be used in humans. Dr Hou’s research aims to develop eye drops that can treat pterygium which are not severe enough to warrant surgery, or be used together with surgery to prevent post surgical recurrence.

     
    Education

    • 2008   Ph.D. – Nanyang Technological University
    • 2002   Master of Science – Shandong University, China
    • 1999   Bachelor of Science – Huazhong Agriculture University, China

     

    Previous Positions

    • 2008   Postdoctoral Research Fellow, Nanyang Technological University

     

    Awards

    • 2003    Research Scholarship, Nanyang Technological University, Singapore
    • 2005    Teaching assistant scholarship, Nanyang Technological University, Singapore
    • 2002    Guanghua fellowship of Shandong University, China

     

     Selected publications:

    1. Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion. Tong L, Png E, Aihua H, Yong SS, Yeo HL, Riau A, Mendoz E, Charausia SS, Lim CT, Yiu TW, Iismaa SE. Biochim Biophys Acta. 2013 Jun;1833 (6):1304-15.
    2. Lan W, Hou Aihua, Tong L. Regulation of gene expression in pterygium. Introduction to Genetic (DNA methylation and gene regulation). Editor: Jun Wan, 2012, iConcept Press Ltd. ISBN: 978-14775549-4-4.
    3. Aihua Hou, Shuan-Pei Lin, Shi Yin Ho, et al. Genetic Studies of Prader–Willi Patients Provide Evidence for Conservation of Genomic Architecture in Proximal Chromosome 15q. Annals of Human Genetics 2011, 75 (2): 211–221.
    4. Andri K. Riau, Tina T. Wong, Sharon N. Finger, Shyam S. Chaurasia, Aihua Hou, Silin Chen, Shang Juan Yu, and Louis Tong.  Aberrant DNA Methylation of Matrix Remodeling and Cell Adhesion Related Genes in Pterygium. PLoS One. 2011; 6(2): e14687.
    5. Tong L, Lan WW, Petznick A, Hou Aihua. “Advances in Pathogenesis of Pterygium“, Book chapter in Advances in Eye Research Volume 2, 2011, William L Thomsen, Nova Science Publishers Inc, Hauppague, NY.
    6. Mei-Yi Wu, Ken-Shiung Chen, Jan Bressler, Aihua Hou, Ting-Fen Tsai, and Arthur L.   Beaudet. Mouse imprinting defect mutations that model Angelman syndrome. Genesis 2006, 44: 12-22.

    Prof Paul L KAUFMAN

    Prof Paul L KAUFMAN

    MD, MD (HC)

    Senior Consultant Advisor

    Email: kaufmanp@mhub.ophth.wisc.edu

    Dr Kaufman is the Ernst H. Bárány Professor of Ocular Pharmacology and immediate past Chair of the Department of Ophthalmology & Visual Sciences at the University of Wisconsin School of Medicine and Public Health, in Madison, Wisconsin. He is a physician-scientist, specializing in glaucoma. His research laboratory studies the physiology, pharmacology, cell biology, neural control and ageing of the primate aqueous humor formation and drainage, and the accommodative, apparatus, seeking to gain new pathophysiological insights and to develop novel pharmacologic and genetic therapies for human glaucoma and presbyopia.

    Dr Kaufman is a past President and past Executive Vice President of the Association for Research in Vision and Ophthalmology, past President of the International Society for Eye Research, and has served on the US National Advisory Eye Council and numerous foundation and corporate scientific advisory boards. He has had continuous research funding from the US National Eye Institute for 35 years, has authored over 350 original scientific articles and 75 book chapters, co-edited several textbooks including the most recent editions of Adler’s Physiology of the Eye, and received numerous honors and awards. He was Editor-in-Chief of Investigative Ophthalmology & Visual Science from 2008 through 2012. Dr Kaufman also holds an honorary Doctor of Medicine degree from Uppsala University in Sweden.

    Dr Kaufman is married to the novelist Margaret George, and together they have a daughter who earned an undergraduate degree from Harvard University and a doctorate from the University of California-Berkeley, in China and East-Asian studies. She lives with her husband and daughter in Washington DC, where she is a policy analyst / advisor in her major field. Dr Kaufman notes that while he was Chair, he could not find his other interests, which used to be history, political thought, espionage, theatre, certain types of music, and running.

    Other Concurrent Positions

    • Ernst H. Bárány Professor of Ocular Pharmacology, University of Wisconsin-Madison
    • Professor Ophthalmology and Visual Sciences, University of Wisconsin-Madison
    • Affiliate Scientist, Wisconsin National Primate Research Center
    • Member, McPherson Eye Research Institute, University of Wisconsin

    Research Interests

    • Aqueous humor dynamics
    • Anterior ocular segment physiology & pharmacology
    • Intraocular pressure regulation
    • Glaucoma
    • Ocular gene therapy
    • Accommodation
    • Presbyopia

    Education

    • 1957-1960
    Bronx High School of Science, New York
    • 1960-1963
    Tufts University, Medford, Chemistry-Biology
    • 1963-1967
    MD, New York University School of Medicine, New York
    • 1967-1968
    Intern, Straight Medicine, Bellevue Hospital, Columbia University Medical Division, New York
    • 1968-1970
    Military Service: Staff Associate, Biometry Branch, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD
    • 1970-1973
    Resident in Ophthalmology, Washington University School of Medicine and Barnes Hospital, St. Louis, MO
    • 1973-1975
    Seeing Eye and NIH Research Fellow in Ocular Pharmacology, Departments of Pharmacology and Physiology, University of Uppsala, Uppsala, Sweden (Drs. Ernst Bárány and Anders Bill)

    Previous Positions

    • 1975-2004
    Asst, Assoc, Full Prof, Dept of Ophthalmol & Vis Sci (Acting Chair 92)
    • 1975-2004
    Director, Glaucoma Service, UW-Madison
    • 1991-1994
    Member, National Advisory Eye Council, NIH
    • 1992-2003
    Councilor/ Pres-Elect/ Pres Int Soc Eye Res
    • 1993-2008
    Trustee, Pres & Exec VP, ARVO
    • 2004-2014
    Peter A. Duehr Professor and Chairman, Dept Ophthalmology Vis Sci UW-Madison
    • 2007-2012
    Editor-in-Chief, Invest Ophthalmol Vis Sci

    Awards

    • 2013
    AAO Senior Achievement Award
    • 2013
    ARVO Joanne G Angle Service Award
    • 2013
    ARVO Distinguished Service Award
    • 2012
    The Goldmann Award, Glaucoma Research Society
    • 2010
    WARF Named Professorship, Wisconsin Alumni Research Foundation/ University of Wisconsin
    • 2009
    ARVO Gold Fellow
    • 2009
    AGS Guest of Honor, American Glaucoma Society, 19th Annual Meeting
    • 2007
    ARVO Distinguished Service Award
    • 2006
    Ernst H. Bárány Prize, Int Soc Eye Res
    • 2004
    Association of International Glaucoma Societies Award for best glaucoma paper of 2003

    Ophthalmology & Scientific Involvement (Professional Memberships)

    • American Academy of Ophthalmology (Fellow)
    • American Glaucoma Society
    • American Ophthalmological Society
    • Association for Research in Vision and Ophthalmology
    • Becker Glaucoma Society
    • Glaucoma Society of the International Congress of Ophthalmology/ Glaucoma Research Society
    • International Society for Eye Research
    • University of Wisconsin Eye Alumni Association
    • Washington University Eye Alumni Association

    Selected Publications (from over 350 peer reviewed publications)

    1. Schwinn MK, Gonzalez JM Jr, Gabelt BT, Sheibani N, Kaufman PL, Peters DM: Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway. Exp Eye Res, 316:1500-1512, 2010. PMCID2871963
    2. Nork TM, Kim CB, Heatley GA, Kaufman PL, Lucarelli MJ, Levin LA, Ver Hoeve JN: Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates. Doc Ophthalmol 120:273-289, 2010. PMCID2933837
    3. Tan JCH, Kiland JA, Gonzalez JM Jr, Gabelt BT, Peters DM, Kaufman PL: Sodium orthovanadate effect on outflow facility and intraocular pressure in live monkeys. Exp Eye Res 91:486-490, 2010. PMCID2946324
    4. Tian B, Heatley GA, Filla MS, Kaufman PL: Effect of H-7 on secondary cataract after phacoemulsification in the live rabbit eye. J Ocular Pharm Ther 26:533-539, 2010. PMCID2990282
    5. Ly T, Gupta N, Weinreb RN, Kaufman PL, Yücel YH: Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma. Vision Res 51:243-250, 2011. PMCID3125971
    6. Elsmo EJ, Kiland JA, Kaufman PL, McLellan GJ: Evaluation of rebound tonometry in non-human primates. Exp Eye Res 92:268-273, 2011. PMCID3060952
    7. Kiland JA, Gabelt BT, Kaufman PL: Relationship of aqueous outflow resistance to age and total volume perfused in rhesus and cynomolgus monkeys. Invest Ophthalmol Vis Sci 52:6820-6824, 2011. PMCID3176014
    8. Gabelt BT, Kaufman PL, Rasmussen CA: Effect of nitric oxide compounds on monkey ciliary muscle in vitro. Exp Eye Res 93:321-327, 2011. PMCID3299082
    9. Kutuzova GD, Gabelt BT, Kiland JA, Hennes-Beann EA, Kaufman PL, DeLuca HF: 1a,25-Dihydroxyvitamin D3 and its analog, 2-methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) suppress intraocular pressure in non-human primates. Arch Biochem Biophys 518:53-60, 2012. PMCID3390938
    10. Sureshkumar J, Haripriya A, Muthukkaruppan V, Kaufman PL, Tian B. Cytoskeletal drugs prevent posterior capsular opacification in human lens capsule in vitro. Graefe’s Arch Clin Exp Ophthalmol 250:507-514, 2012. PMCID3310944
    11. Weinreb RN, Kaufman PL: Glaucoma research community and FDA look to the future, II: NEI/FDA Glaucoma Clinical Trial Design and Endpoints Symposium: measures of structural change and visual function. Invest Ophthalmol Vis Sci 52:7842-7851, 2011. PMCID3207797
    12. Gabelt BT, Rasmussen CA, Tektas OY, Kim CBY, Peterson JC, Nork TM, Ver Hoeve JN, Lütjen-Drecoll E, Kaufman PL: Structure/Function studies and the effects of memantine in monkeys with experimental glaucoma. Invest Ophthalmol Vis Sci 53: 2368-2376, 2012. PMC Journal in Process
    13. Read SA, Williams DR, Wojtkowski M, Roorda A, Nichols JJ, Mutti DO, Kaufman PL, Carney LG. Imaging and measurement in the eye: now and ahead. Optom Vis Sci. 89(5):521-23, 2012
    14. Kaufman PL, Rasmussen CA: Advances in glaucoma treatment and management: outflow drugs. Invest Ophthalmol Vis Sci 53:2495-2500, 2012. PMC Journal – in process
    15. Tian B, Kaufman PL. Comparisons of actin filament disruptors and Rho kinase inhibitors as potential antiglaucoma medications. Expert Rev Ophthalmol 7:177-187, 2012. PMCID3378243
    16. Croft MA, Nork TM, McDonald JP, Katz A, Lütjen-Drecoll E, Kaufman PL: Accommodative movements of the vitreous membrane, choroid and sclera in young and presbyopic human and non-human primate eyes. Invest Ophthalmol Vis Sci 54:5049-5058, 2013. PMCID3726242
    17. Croft MA, McDonald JP, Katz A, Lin T-L, Lütjen-Drecoll E, Kaufman PL: Extralenticular and lenticular aspects of accommodation and presbyopia in human vs. monkey eyes. Invest Ophthalmol Vis Sci 54:5035-5048, 2013. PMCID3726241
    18. Heyne GW, Kiland JA, Kaufman PL, Gabelt BT: Effect of nitric oxide on anterior segment physiology in monkeys. Invest Ophthalmol Vis Sci 54:5103-5110, 2013. PMCID3729238
    19. Rasmussen CA, Kaufman PL, Kiland JA: Benzalkonium chloride and glaucoma. J Ocular Pharm Ther, In press, proof online 11/10,2013
    20. Lee ES, Rasmussen CA, Filla MS, Slauson SR, Peters DM, Kaufman PL, Gabelt BT, Brandt CR: Prospects for lentiviral vector mediated prostaglandin F synthase gene delivery in monkey eyes in vivo. Curr Eye Res, Early Online, 1-12, 2014

    A/Prof Rajamani LAKSHMINARAYANAN

    A/Prof Rajamani LAKSHMINARAYANAN

    Principal Investigator
    Deputy Head, Anti-Infectives Research Group

    Email: lakshminarayanan.rajamani@seri.com.sg

    Dr. Lakshminarayanan is a protein chemist and working on antimicrobial peptides. He received his PhD from the Department of Chemistry at National University of Singapore. After his PhD he received the prestigious Singapore Millennium Foundation and ASEM-DUO-Denmark Fellowships. Later he moved to the University of Southern California and worked on intrinsically disordered proteins.

    Other concurrent positions

    • Adjunct Assistant Professor, Duke-NUS Graduate Medical School

    Research Interests

    Antimicrobial peptides, Protein aggregation, Protein-Protein interactions, Extracellular Matrix Assembly

    Education

    • 2003
    PhD National University of Singapore
    • 1997
    MTech Indian Institute of Technology, New Delhi
    • 1994
    MSc University of Madras
    • 1992
    BSc University of Madras

    Previous Positions

    • 2005
    Research Associate, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, USA.
    • 2002
    Singapore Millennium Foundation – Post Doctoral Fellow, Department of Chemistry, National University of Singapore

    Awards

    • 2008
    Outstanding Postdoctoral Research Award for the year (2nd Prize), Research Day, School of Dentistry, USC
    • 2007
    Outstanding Postdoctoral Research Award for the year 2008 (1st Prize), Research Day, School of Dentistry, USC
    • 2005
    National Institute of Dental and Craniofacial Research (NIDCR) Fellowship, National Institute of Health
    • 2002
    Research Fellowship, Singapore Millennium Foundation
    • 2004
    Denmark Fellowship, ASEM-DUO

    Ophthalmology & Scientific Involvement

    • Member Association of Vision & Research in Ophthalmology

     

    Selected publications from a list of 44 Research Articles & 1 Book Chapter:

    1. Tan XW, Lakshminarayanan R, Liu SP, Goh E, Tan D, Beuerman RW, Mehta JS. Dual functionalization of titanium with vascular endothelial growth factor and β-defensin analogue for potential application in keratoprosthesis. J Biomed Mater Res B Appl Biomater. 2012 Jul 23. doi: 10.1002/jbm.b.32774. (IF=2.147)
    2. Bai Y, Liu S, Li J, Lakshminarayanan R, Padmanabhan S, Tang C, Ho D, Verma C, Beuerman RW, Pervushin K. Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target. J Biol Chem. 2012;287:26606-17. (IF=5.306)
    3. Koh JJ, Qiu S, Zou H, Lakshminarayanan R, Li J, Zhou X, Tang C, Saraswathi P, Verma C, Tan DTH, Tan AL, Liu SP, Beuerman RW. Rapid Bactericidal Action of Alpha-mangostin against MRSA as an Outcome of Membrane Targeting. BBA – Biomembranes (accepted). (IF=4.091)
    4. Liu SP, Zhou L, Lakshminarayanan R, Beuerman RW. Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities. (2010) Int J Pept Res Ther. 2010;16:199-213. 16, 199-213. (IF=0.9884)
    5. Zhou L, Liu SP, Chen LY, Li J, Ong LB, Guo L, Wohland T, Tang CC, Lakshminarayanan R, Mavinahalli J, Verma C, Beuerman RW. The structural parameters for antimicrobial activity, human epithelial cell cytotoxicity and killing mechanism of synthetic monomer and dimer analogues derived from hBD3 C-terminal region. Amino Acids 2011;40:123-133. (IF=3.6286)
    6. Lakshminarayanan, R., Vivekanandan, S., Samy, R. P., Banerjee, Y., Chi-Jin, E. O., Teo, K. W., Jois, S. D. S., Kini, R. M., & Valiyaveettil, S. Structure, self-assembly and dual role of a -defensin like peptide from the Chinese soft-shelled turtle eggshell matrix. J. Am. Chem. Soc. 2008;130:4660-4668. (IF=9.907)
    7. Wellman-Labadie O. Lakshminarayanan R, Hincke, MT. Antimicrobial properties of avian eggshell-specific C-type Lectin-like proteins. FEBS Lett. 2008, 582, 699-704. (IF=3.538)
    8. Lakshminarayanan R, Yoon I, Hegde BG, Fan D, Du C, and Moradian-Oldak J. Analysis of secondary structure and self-assembly of amelogenin by variable temperature circular dichroism and isothermal titration calorimetry. Proteins. 2009;76:560-9. (IF=3.392)
    9. Lakshminarayanan R, Fan D, Du C and Moradian-Oldak, J. The role of secondary structure in the entropically driven amelogenin self-assembly. Biophs. J. 2007;93:3664-3674. (IF=4.2982)
    10. Cho KR, Huang Y, Yu S, Yin S, Plomp M, Qiu SR, Lakshminarayanan R, Moradian-Oldak J, Sy MS, De Yoreo JJ. A multistage pathway for human prion protein aggregation in vitro: from multimeric seeds to β-oligomers and non-fibrillar structures. J Am Chem Soc. 2011;133:8586-8593. (IF=9.907)

    Prof Ecosse LAMOUREUX

    Prof Ecosse LAMOUREUX

    PhD; M.Appl.Sci; Grad.Dip; B.Ed.

    Director, Population Health
    Head, Health Services Research Group
    Head, Data Management Support Platform
    Head, Population Health Support Platform
    Head, Singapore Ocular Reading Centre (SORC)

    Email: ecosse.lamoureux@seri.com.sg

    Prof Ecosse Lamoureux is also the Deputy Executive Director of the new Academic Medicine Research Institute (AMRI), and an Adjunct Professor in Health Services and Systems Research at Duke-Graduate Medical School, Singapore.

    My current research in Australia, Singapore and elsewhere is focused on improving the prevention; treatment; compliance to disease management; and patient-centred outcomes for people with diabetes, diabetic retinopathy (DR); and other ocular conditions. The multi-disciplinary nature of my work is reflected by the breadth of my research programme mostly funded by the highly esteemed and competitive Australian National Health and Medical Research Council (NHMRC) Australian Research Council (ARC), and Singapore National Medical Research Council (NMRC) the premier national medical funding institutions in Australia and Singapore. I am currently the Principal Investigator (PI) of four NHMRC projects, three ARC linkage grants and Co-PI on five NHMRC projects. To date, my research activities have attracted over US$13 million in Australian grant funding and an additional US$2.0 million from international competitive grants. My translational research program has therefore an exciting potential to: (a) improve the understanding of the epidemiology, pathophysiology, and risk factors of major eye diseases; (b) enhance the early detection and treatment of DR and other eye diseases; (c) identify the determinants of poor compliance to DR and glaucoma management; (d) determine the effectiveness of intervention trials and RCTs to improve compliance to DR and glaucoma management; and (e) evaluate the comprehensive impact of eye diseases from the patient’s perspective knowledge and disease-specific literacy ultimately leading to better health outcomes and substantial gains in disease-specific QoL.

    Other concurrent positions

    • Deputy Executive Director, Academic Medicine Research Institute (AMRI)
    • Professor, Office of Clinical Sciences, Duke NUS Medical School, Singapore
    • Adjunct Professor, Health Services and Systems Research
    • Professor, Dept. of Ophthalmology, National University of Singapore, Singapore
    • Associate Professor, Dept. of Ophthalmology, University of Melbourne, Australia.

    Research Interests

    Health services and translational eye research; ocular epidemiology; and patient-centered outcomes in eye and cardiovascular diseases

    Education

    • 1992
    Deakin University, Australia, Bachelor of Education
    • 1992
    Deakin University, Australia, Graduate Diploma
    • 1996
    Deakin University, Australia, Master of Applied Science
    • 2001
    Deakin University, Australia, Doctor of Philosophy

    Previous Positions

    • 2005
    Senior Research Fellow, Centre for Eye Research Australia, Department of Ophthalmology University of Melbourne

    Awards

    • 2013-current
    NHMRC Senior Research Fellowship-Level B
    • 2009-2012
    NHMRC Career Development Award Fellowship
    • 2005-2009
    NHMRC Public Health Postdoctoral Fellowship

    Ophthalmology & Scientific Involvement

    • 2004-current
    Association for vision research in ophthalmology
    • 2005-current
    Australian society for medical research
    • 2006-current
    Ophthalmic research institute of Australia
    • 2006-current
    Australian center for evidence based clinical practice.
    • 2012-current
    Australian NHMRC research translation faculty.
    • 2011- Current
    Asia-Pacific Journal of Ophthalmology (APJO)
    • 2011- Current
    Translational Vision Science & Technology (TVST)

    Selected publications (from 205+)

    1. Rees, G., Lamoureux, E.L, Nicolaou, T.E., Hodgson, L.A., Weinman, J., Speight, J., Feedback of personal retinal images appears to have a motivational impact in people with non-proliferative diabetic retinopathy and suboptimal HbA1c: findings of a pilot study. Diabetic Medicine 2013 Mar 21 doi: 10.1111/dme.12192. (Epub ahead of print).
    2. Yip, W., Wong, T.Y., Jonas, J.B., Zheng, Y., Lamoureux, E.L., Nangia., V., Sabanayagam, C. Prevalence, awareness and control of hypertension among Asian Indians living in urban Singapore and rural India. J. Hypertension (Accepted 4 Apr 2013)
    3. Chew, S.K., Taouk, Y., Xie, J., Nicolaou, T.E., Wang, J.J., Wong, T.Y., Lamoureux, E.L. The relationship of diabetic retinopathy and diabetic macular oedema with erectile dysfunction in patients with type 2 diabetes. Clinical & Experimental Ophthalmology. 2013 Feb 28 12099 (Epub ahead of print).
    4. Noonan, J.E., Luu, C.D, Man, R.E.K., Lamoureux, E.L. Neurovascular Dysfunction Precedes Neural Dysfunction in the Retina of Patients with Type 1 Diabetes. Investigative Ophthalmology & Visual Science 2013 Jan 30;54(1):842-7.
    5. Zheng. Y.F., Cheng, C.Y., Lamoureux, E.L., P., Saw, S.M., Wong, T.Y. How much Eye Care Services Do Asian Populations Need? Projection from the Singapore Epidemiology of Eye Disease (SEED) Study. Investigative Ophthalmology & Visual Science 2013 Feb 25 doi: iovs.12-11393v1 [pii] (Epub ahead of print)
    6. Sasaki, M., Kawasaki, R., Noonan, J., Wong, T., Lamoureux, E.L., Wang, J.J. Quantitative measurement of hard exudates in patients with diabetes and their associations with serum lipid levels. Investigative Ophthalmology &Visual Science (Accepted 4 Feb 2013).
    7. Larizza, M.F., Hodgson, L.A., Fenwick, E.K., Kawasaki, R., Audehm, R., Wang, J.J., Wong, T.Y., Lamoureux, E.L. Feasibility of screening for diabetic retinopathy at an Australian pathology collection service: a pilot study. Medical Journal of Australia. 2013. 198(2):97-9.
    8. Chiang, P.C., Zheng, Y., Wong, T.Y., Lamoureux, E.L. Vision Impairment and Major Causes of Vision Loss Impacts on Vision-specific Functioning Independent of Socio-Economic Factors Ophthalmology 2013. 120(2):415-22.
    9. Foo, R., Lamoureux, E.L., Wong, R., Ho, S.W., Chiang, P., Aung, T., Rees, G., Wong, T.T. Acceptance, Attitudes and Beliefs of Singaporean Chinese towards an Ocular Implant for Glaucoma Drug Delivery. Investigative Ophthalmology & Visual Science 2012. 53(13):8240-5.
    10. Zheng, Y., Lamoureux, E.L., Chiang, P.C., Anuar, A.R., Ding, J., Wang, J.J., Mitchell, P., Tai, E.S., Wong, T.Y. Language barrier and its relationship to diabetes and diabetic retinopathy.BMC Public Health. 2012 13;12(1):781.

    Dr LEE Mei Chin

    Dr LEE Mei Chin

    PhD

    Senior Research Fellow

    Email: lee.mei.chin@seri.com.sg

    Dr Lee graduated from the University of Queensland with First-class Honours in Microbiology, and was on the Dean’s list for her BSc. with double majors in Biochemistry and Microbiology. She then moved on to the Institute of Molecular and Cell Biology in Singapore, where she was chosen and awarded with A*STAR Scientific Staff Development Award. Under A*STAR sponsorship, she obtained her Ph.D. in Biochemistry from the National University of Singapore. Dr. Lee currently holds Adjunct appointments with DUKE-NUS Academic Clinical Program for Ophthalmology and Visual Sciences, and Singapore National Eye Centre. Her research training was in Cell Biology, Molecular Biology, Drug Screening and Biochemistry. She joined SERI in 2012 and her current research focuses on the functional characterization of candidate genes identified via genome wide association study (GWAS) and quantitative trait loci (QTL) analysis for rare and common eye diseases.

     

    Other concurrent positions

    • Adjunct Instructor, Academic Clinical Program for Ophthalmology and Visual Sciences, Office of Clinical & Academic Faculty Affairs, Duke-NUS Graduate Medical School
    • Adjunct Senior Research Fellow, Glaucoma Service, Singapore National Eye Centre

     

    Research Interests

    • Implementation and utilization of biochemical and cell-based approaches to explore the mechanisms of susceptibility genes in relation to the pathophysiological aspects of glaucoma type diseases
    • To convert basic research knowledge to translational research leading to drug development in an aid to alleviate glaucoma disease progression

     

    Education

    • 2010   Ph.D in Biochemistry, National University of Singapore
    • 2003   First Class Honours in Microbiology, The University of Queensland, Australia
    • 2002   B Sc (Dean’s List) with double majors in Biochemistry and Microbiology, The
      0000   University of Queensland, Australia

     

    Previous Positions

    • 2012-2014 Postdoctoral Research Fellow, Singapore Eye Research Institute
    • 2010-2011 Postdoctoral Research Fellow, Institute of Molecular and Cell Biology, A*STAR
    • 2005-2010 Senior Research Officer, Institute of Molecular and Cell Biology, A*STAR
    • 2003-0000 Teaching Assistant, The University of Queensland, Australia

     

    Awards

    • 2004-2010 Scientific Staff Development Award from A*STAR, Singapore
    • 2009-0000 Best Poster Award, IMCB Scientific Retreat, Singapore
    • 2002-0000 Dean’s commendation for high achievement, The University of Queensland,
      0000-0000 Australia

     

    Ophthalmology & Scientific Involvement

    • Member, The Association for Research in Vision and Ophthalmology

     

     Selected Publications:

    1. Li Z, Allingham RR, Nakano M, Jia L, Chen Y, Ikeda Y, Mani B, Chen LJ, Kee C, Garway-Heath DF, Sripriya S, Fuse N, Abu-Amero KK, Huang C, Namburi P, Burdon K, Perera SA, Gharahkhani P, Lin Y, Ueno M, Ozaki M, Mizoguchi T, Krishnadas SR, Osman EA, Lee MC, Chan AS, Tajudin LS, Do T, Goncalves A, Reynier P, Zhang H, Bourne R, Goh D, Broadway D, Husain R, Negi AK, Su DH, Ho CL, Blanco AA, Leung CK, Wong TT, Yakub A, Liu Y, Nongpiur ME, Han JC, Hon DN, Shantha B, Zhao B, Sang J, Zhang N, Sato R, Yoshii K, Panda-Jonas S, Ashley Koch AE, Herndon LW, Moroi SE, Challa P, Foo JN, Bei JX, Zeng YX, Simmons CP, Bich Chau TN, Sharmila PF, Chew M, Lim B, Tam PO, Chua E, Ng XY, Yong VH, Chong YF, Meah WY, Vijayan S, Seongsoo S, Xu W, Teo YY, Cooke Bailey JN, Kang JH, Haines JL, Cheng CY, Saw SM, Tai ES; ICAARE-Glaucoma consortium; NEIGHBORHOOD consortium, Richards JE, Ritch R, Gaasterland DE, Pasquale LR, Liu J, Jonas JB, Milea D, George R, Al-Obeidan SA, Mori K, MacGregor S, Hewitt AW, Girkin CA, Zhang M, Sundaresan P, Vijaya L, Mackey DA, Wong TY, Craig JE, Sun X, Kinoshita S, Wiggs JL, Khor CC, Yang Z, Pang CP, Wang N, Hauser MA, Tashiro K, Aung T, Vithana EN..A common variant near TGFBR3 is associated with primary open angle glaucoma. . Hum Mol Genet.2015 Apr 10. pii: ddv128. [Epub ahead of print] (IF=8.05)
    2. Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS, Abu-Amero KK, Zenteno JC, Nilgün Y, Zarnowski T, Pakravan M, Safieh LA, Jia L, Wang YX, Williams S, Paoli D, Schlottmann PG, Huang L, Sim KS, Foo JN, Nakano M, Ikeda Y, Kumar RS, Ueno M, Manabe S, Hayashi K, Kazama S, Ideta R, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Inoue K, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Aihara M, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Matsuda F, Yamashiro K, Gotoh N, Miyake M, Astakhov SY, Osman EA, Al-Obeidan SA, Owaidhah O, Al-Jasim L, Shahwan SA, Fogarty RA, Leo P, Yetkin Y, Oğuz Ç, Kanavi MR, Beni AN, Yazdani S, Akopov EL, Toh KY, Howell GR, Orr AC, Goh Y, Meah WY, Peh SQ, Kosior-Jarecka E, Lukasik U, Krumbiegel M, Vithana EN, Wong TY, Liu Y, Koch AE, Challa P, Rautenbach RM, Mackey DA, Hewitt AW, Mitchell P, Wang JJ, Ziskind A, Carmichael T, Ramakrishnan R, Narendran K, Venkatesh R, Vijayan S, Zhao P, Chen X, Guadarrama-Vallejo D, Cheng CY, Perera SA, Husain R, Ho SL, Welge-Luessen UC, Mardin C, Schloetzer-Schrehardt U, Hillmer AM, Herms S, Moebus S, Nöthen MM, Weisschuh N, Shetty R, Ghosh A, Teo YY, Brown MA, Lischinsky I; Blue Mountains Eye Study GWAS Team; Wellcome Trust Case Control Consortium 2, Crowston JG, Coote M, Zhao B, Sang J, Zhang N, You Q, Vysochinskaya V, Founti P, Chatzikyriakidou A, Lambropoulos A, Anastasopoulos E, Coleman AL, Wilson MR, Rhee DJ, Kang JH, May-Bolchakova I, Heegaard S, Mori K, Alward WL, Jonas JB, Xu L, Liebmann JM, Chowbay B, Schaeffeler E, Schwab M, Lerner F, Wang N, Yang Z, Frezzotti P, Kinoshita S, Fingert JH, Inatani M, Tashiro K, Reis A, Edward DP, Pasquale LR, Kubota T, Wiggs JL, Pasutto F, Topouzis F, Dubina M, Craig JE, Yoshimura N, Sundaresan P, John SW, Ritch R, Hauser MA, Khor CC. A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. Nat Genet. 2015 Apr;47(4):387-92. (IF=36.37)
    3. Lee MC, Chan AS, Goh SR, Hilmy MH, Nongpiur ME, Hong W, Aung T, Hunziker W, Vithana EN.Expression of the primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 in endothelial and epithelial cell junctions in the eye. Invest Ophthalmol Vis Sci. 2014 May 6;55(6):3833-41. (IF=3.431)
    4. Goh LH, Zhou X, Lee MC, Lin S, Wang H, Luo Y, Yang X.Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains. Dev Biol. 2013 Sep 15;381(2):353-64.Cover story. (IF=4.069)
    5. He H, Lee MC, Zheng LL, Zheng L, Luo Y. Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes. Biosci Rep. 2013 Feb 1;33(2):e00018. (IF=2.853)
    6. Lee MC, Toh LL, Yaw LP, Luo Y. Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genes.J Biol Chem. 2010 Mar 19;285(12):9041-53. (IF=4.773)
    7. Wan KF, Chan SL, Sukumaran SK, Lee MC, Yu VC. Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. J Biol Chem. 2008 Mar 28;283(13):8423-33. (IF=4.773)
    8. Zhang YH, Bhunia A, Wan KF, Lee MC, Chan SL, Yu VC, Mok YK. Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft. J Mol Biol. 2006 Dec 1;364(3):536-49. (IF=4.001)
    9. Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD, Yu VCIdentification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6. (IF=4.773)

    Dr Yong LI

    Dr Yong LI

    MD

    Principal Investigator, SERI-IMCB Program in Retinal Angiogenic Diseases (SIPRAD)

    Email: yong.li@seri.com.sg

    As a key SIPRAD investigator, Dr Li is one of the team leaders in SIPRAD program to develop a unique industry-standard research platform. He has demonstrated track record and expertise in clinical and translational ophthalmology to contribute towards the furtherance of the SIPRAD mission. Dr Li also has a long-standing interest in developing novel animal model for the therapeutic industry. He has served as a project leader of ocular pharmacology, providing scientific leadership and involved in comprehensive understanding of clinical aspects as well as drug development of the human disease therapeutics. A significant impetus for Dr Li’s research has been the translation of laboratory advances into clinical trials of novel therapeutic. This was exemplified during his career with Allergan where he was involved in commercialization of Ozurdex for diabetic macular edema (FDA approved) and DARPin-based anti-angiogenic drug for Wet AMD (Phase III).

    Research Interests

    He has taken special interest in developing animal models in diverse animals in ocular inflammation; retinal angiogenic diseases included Wet AMD and diabetic retinopathy, macular edema and Uveitis, to test the diverse experimental therapies. His experience as an accomplished ophthalmologist involves hands-on microsurgical skill, ocular imaging, electrophysiology as well as drug delivery and histology in patients and diverse animals (from mice to monkeys).

    Education

  • 1982
  • Jilin Medical College, Beihua University, China, Doctor of Medicine (M.D.)

    Previous Positions

  • 2014-2006
  • Scientist, Ocular Pharmacology, Biological Science, Allergan Inc, USA
  • 2006-2005
  • Senior Research Associate, Preclinical Pharmacology, Fibrogen Inc, USA
  • 2005-2004
  • Scientist, Pharmacology, Kia Pharmaceuticals, USA

    Awards

  • 2012
  • Award for Excellence, Presence by Drug Safety Evaluation, Allergan Inc
  • 1997
  • The Rachel C. Atkinson, Fellowship for Eye Research Award, The Smith-Kettlewell Eye Research Institute

    Ophthalmology & Scientific Involvement

    • Member, The Association for Research in Vision and Ophthalmology (ARVO)

    Selected publications

    1. Zacharias LC, Lin T, Migon R, Ghosn C, Orilla W, Feldmann B, Ruiz G, Li Y, Burke J, Kuppermann BD (2013). Assessment of the differences in pharmacokinetics and pharmacodynamics between four distinct formulations of triamcinolone acetonide. Retina 33(3):522-31
    2. Ghosn CR, Li Y, Orilla WC, Lin T, Wheeler L, Burke JA, Robinson MR, Whitcup SM (2011). Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant. Invest Ophthalmol Vis Sci 52(6):2917-23
    3. Albert DM, Dubielzig RR, Li Y, Lin T, Neekhra A, Orilla W, Ramos M, Salamat MS, Burke JA (2009). Choroidal melanoma occurring in a nonhuman primate. Arch Ophthalmol Aug 127(8):1080-2
    4. Atabai K, Fernández R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhardt C, Zhu W, Pytela R, Werb Z, Sheppard D (2005). Mfge8 Is critical for mammary gland remodeling during involution. Mol Biol Cell 16(12):5528-37
    5. Shimada Y, Li Y, Bearse MA Jr, Sutter EE, Fung W (2001). Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br J Ophthalmol 85 (94):414-19
    6. Frishman LJ, Saszik S, Harwerth RS, Viswanathan S, Li Y, Smith EL, Robson JG, Barnes G (2000). Effects of experimental glaucoma in macaques on the multifocal ERG Doc Ophthalmol 100(2-3):231-51
    7. Sutter EE, Shimada Y, Li Y, Bearse MA Jr (1999). Mapping inner retinal function through enhancement of adaptive components in the M-ERG Vision Science and its Applications, OSA Technical Digest Series 1: 52-55
    8. Li Y, Mori T, Kato C, Nakajima S (1998). A clinical evaluation on the positive/negative ratio in amplitude on the multifocal electroretinogram. Folia Opthamol Jpn 49:750-53
    9. Mori T, Kato C, Nakajima S, Li Y (1997). Multifocal electroretinograms recorded after surgery for retinal detachment involving the macula. Folia Ophthalmol Jpn 48:571-76
    10. Mori T, Kato C, Nakajima S, Li Y (1997). The relation between the visual acuity and response density of multifocal electroretinogram. Rinsho Ganka (Jpn Clin Ophthalmol) 51(4):485-88

    Dr LIU Yu-Chi

    Dr LIU Yu-Chi

    Clinician Scientist

    Email: liu.yu.chi@seri.com.sg

    Dr. Liu, Yu Chi graduated from Taipei Medical University, Taiwan, and joined SERI from 2011 after she obtained the certificate of specialty in Ophthalmology. Besides clinical work, she is also engaged in translational research. Her interests of research are corneal transplantation, refractive surgery, ophthalmic epidemiology, and drug delivery system.

    ACADEMIC QUALIFICATION

  • 2013-present
  • Master of Clinical Investigation (MCI), National University of Singapore, Singapore
  • 1998-2005
  • Doctor of Medicine (MD), Taipei Medical University, Taipei, Taiwan

    PROFESSIONAL QUALIFICATION AND LICENSE

  • 2012
  • Certificate of Medical Registration and Practicing Certificate, Singapore Medical Council
  • 2010
  • The Clinical Science Examination in Ophthalmology, International Council of Ophthalmology
  • 2009
  • The Basic Science Examination in Ophthalmology, International Council of Ophthalmology
  • 2009
  • Certificate of Specialty in Ophthalmology, Department of Health, Taiwan
  • 2005
  • Physician Practicing Certificate, Department of Health, Taiwan

    PROFESSIONAL EXPERIENCE AND TRAINING (CAREER HISTORY)

  • 2017
  • Clinician Scientist, Singapore Eye Research Institute
  • 2014 – 2017
  • Senior Clinical Research Fellow, Singapore Eye Research Institute
  • 2011 – 2013
  • Clinical Research Fellow, Singapore Eye Research Institute
  • 2009 – 2010
  • Clinical Fellow, Corneal and External Eye Disease Service, Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
  • 2009 – 2010
  • Clinical Lecturer, Department of Ophthalmology, School of Medicine, National Defense Medical Centre, Taipei, Taiwan
  • 2008 – 2009
  • Chief Resident in Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
  • 2005 – 2008
  • Resident in Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan

    HONORS AND AWARDS

  • 2014
  • World Ophthalmology Congress (WOC) Travel Grant Award
  • 2013
  • ExxonMobil-NUS Research Fellowship for Clinicians Award
  • 2013
  • MOH Healthcare Research Scholarship Award
  • 2009
  • Top 1 in National Board Ophthalmology Examination, Taiwan
  • 2008
  • Best Resident Oral Presentation, the 48st Annual Meeting of Taiwan Ophthalmological Society
  • 2005
  • Best Intern Award, Taipei Veterans General Hospital, Taiwan
  • 2003
  • Academic Top Scholarship (class standing: number one), Taipei Medical University, Taiwan
  • 2001 – 2004
  • Excellent Scholarship (class standing: top five), Shui-Wang Ho Medical Foundation, Taipei Medical University, Taiwan

    PROFESSIONAL MEMBERSHIP

    • Association for Research in Vision and Ophthalmology, USA
    • American Academy of Ophthalmology, USA
    • American Society of Cataract and Refractive Surgeons, USA
    • Association for Cataract and Refractive Surgery, Taiwan
    • Taiwan Ophthalmological Society

    PUBLICATIONS (PEER-REVIEW ARTICLES)

    1. Ang AY, Liu YC, Tan DT, Mehta JS. Descement stripping automated endothelial keratoplasty with the EndoGlide Ultrathin graft insertion device. Expert Rev Med Devices 2014;In Press.
    2. Liu YC, Alvarez Paraz CM, Cajucom-Uy HY, Agahari D, Sethuraman S, Tan DT, Mehta JS. Risk factors for donor endothelial loss in eye bank-prepared posterior lamellar corneal tissue for descemet stripping automated endothelial keratoplasty. Cornea 2014;33:677-82.
    3. Riau AK, Liu YC, Lwin NC, Ang HP, Tan NY, Yam GH, Tan DT, Mehta JS. Comparative study of nJ- and uJ-energy level femtosecond lasers: evaluation of flap adhesion strength, stromal bed quality, and tissue responses. Invest Ophthalmol Vis Sci 2014;55:3186-94.
    4. Liu YC, Peng Y, Lwin NC, Venkatraman SS, Wong TT, Mehta JS. A Biodegradable, sustained-released, prednisolone acetate microfilm drug delivery system effectively prolongs corneal allograft survival in the rat keratoplasty model. PLoS One 2013;8:e70419.
    5. Liu YC, Tsai CC, Lee FL, Lee SM, Kao SC. Mortality from Uveal Melanoma Treated by Enucleation— A 16-year Survey in Taiwan. Acta Ophthalmol 2013;91:e583-4.
    6. Liu YC, Peng Y, Lwin NC, Wong TT, Venkatraman SS, Mehta JS. Optimization of Subconjunctival Biodegradable Microfilms for Sustained Drug Delivery to the Anterior Segment in a Small Animal Model. Invest Ophthalmol Vis Sci 2013;54:2607-15.
    7. Liu YC, Wong TT, Mehta JS. Intraocular lens as a drug delivery reservoir. Curr Opin Ophthalmol 2013;24:53-9.
    8. Liu YC, Chou P, Wojciechowski R, Lin PY, Liu CJ, Chen SJ, Liu JH, Hsu WM, Cheng CY. Power vector analysis of refractive, corneal and internal astigmatism in an elderly Chinese population: the Shihpai Eye Study. Invest Ophthalmol Vis Sci 2011;52:9651-7.
    9. Liu YC, Yen MY, Wang AG. “Seeing but Not Identifying”: pure alexia coincident with prosopagnosia in occipital arteriovenous malformation. Grafes Arch Clin Exp Ophthalmol 2011;249:1087-9.
    10. Guo YC, Liu YC, Lee AF, Lee SM. Long-term follow-up of congenital Aniridia- A Case Report. Taiwan J Ophthalmol 2010;49:192-7.
    11. Liu YC, Liu SY, Lin MH, Cheng PC, Chen LL, Chen TC, Cheng YC, Hsu KC, Chiang WF, Lee CH. Possible mechanism involved in betel quid extract (BQE) induced MMP-2 expression. J Formos Med Assoc 2010;109:838-47.
    12. Chen LC, Liu YC, Liang YC, Ho YS, Lee WS. Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1. J Agric Food Chem 2009;57:7331-7.
    13. Tseng MY, Liu SY, Chen HR, Wu YJ, Chiu CC, Chan PT, Chiang WF, Liu YC, Lu CY, Jou YS, Chen JY. Serine protease inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma. Oral Oncol 2009;45:771-6.
    14. Liu YC, Lau LI, Lee FL, Ko YC, Hsu WM. Recurrent acute angle-closure attacks in age-related macular degeneration-associated massive posterior segment hemorrhage. Jpn J Ophthalmol 2009;53:190-1.
    15. Liu YC, Yang CS, Shyong MP, Lee FL, Lee SM. Intravitreal injection of bevacizumab for the treatment of choroidal neovascularization in a patient with angioid streaks. J Chin Med Assoc 2009;72:98-102.
    16. Chen YC, Liu YC, Yen DH, Wang LM, Huang CI, Lee CH, Lin MT. L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke. Shock 2008;29:212-6.
    17. Liu YC, Kao SC, Tsai CC, Hsu WM. Unilateral traumatic carotid-cavernous fistula with bilateral ocular manifestations treated by transvascular embolization— a case report. Taiwan J Ophthalmol 2008;47:182-7.

    CONFERENCE PRESENTATION

    Invited Speaker

    The role of histone deacetylase inhibitor in corneal fibrosis. The 8th International Symposium of Ophthalmology, Hong Kong, 2012

    Oral and Poster Presentation

    1. New instruments for lenticule extraction in small incision lenticule extraction (SMILE). American Academy of Ophthalmology Annual Meeting, Chicago, USA (Poster, 2014).
    2. Ultrathin corneal grafts for Descemet stripping automated keratoplasty (DSAEK) prepared by a low-pulse energy, high-frequency femtosecond laser with endothelial approach. European Society of Cataract & Refractive Surgeons, London, UK (Poster, 2014)
    3. Use of anterior segment optical coherence tomography to predict corneal graft rejection in small animal models. Association for Research in Vision and Ophthalmology Annual Meeting, Orlando, Florida, USA (Poster, 2014)
    4. Donor, tissue, and precut procedure risk factors for donor endothelial loss in eye bank-prepared posterior lamellar corneal tissue for Descemet stripping automated endothelial keratoplasty. World Ophthalmology Congress, Tokyo, Japan (Oral Presentation, 2014)
    5. Optimization of subconjunctival biodegradable microfilms for sustained drug delivery to the anterior segment in a small animal model. Association for Research in Vision and Ophthalmology Annual Meeting, Seattle, Washington. (Poster, 2013)
    6. A biodegradable, sustained-released, prednisolone acetate microfilm prolongs corneal allograft survival in the rat keratoplasty model. The 26th APACRS Annual Meeting, Singapore (Poster, 2013)
    7. Power vector analysis of refractive, corneal and internal astigmatism in an elderly Chinese population: the Shihpai Eye Study. Association for Research in Vision and Ophthalmology Annual meeting, Florida, USA (Poster, 2011)
    8. Recurrent cytomegalovirus corneal endothelitis after penetrating keratoplasty. The 52th Annual Meeting of Taiwan Ophthalmological Society, Taipei, Taiwan (Oral Presentation, 2011)
    9. Factors affecting changes in intraocular pressure after pharmacologic mydriasis in an elderly Chinese population: the Shihpai Eye Study. Asia-Pacific Joint Glaucoma Congress, Taipei, Taiwan (Oral Presentation, 2010)
    10. Pure alexia coincident with prosopagnosia in occipital arteriovenous malformation. Asia Pacific Academy of Ophthalmology, Beijing, China (Poster, 2010)
    11. Outcomes of uveal melanomas treated by enucleation— A 16-year survey in Taiwan. The 51th Annual Meeting of Taiwan Ophthalmological Society, Taipei, Taiwan (Best Oral presentation, 2010)
    12. Primary calcium carbonate keratopathy. The 50th Annual Meeting of Taiwan Ophthalmological Society, Taipei, Taiwan (Best Oral Presentation, 2009)
    13. Long-term follow-up of congenital aniridia. The 49th Annual Meeting of Taiwan Ophthalmological Society, Taipei, Taiwan (Oral Presentation, 2008)
    14. Systemic steroid-induced central serous chorioretinopathy in the fellow eye during the therapeutic course of acute retinal necrosis. The 48th Annual Meeting of Taiwan Ophthalmological Society, Taipei, Taiwan (Oral Presentation, 2007)
    15. Intravitreal injection of bevacizumab for the treatment of choroidal neovascularization in patients with angioid streaks. The 47th Annual Meeting of Taiwan Ophthalmological Society, Taipei, Taiwan (Best Oral Presentation, 2006)
    16. Recurrent acute angle-closure attacks in age-related macular degeneration-associated massive posterior segment hemorrhage. The 47th Annual Meeting of Taiwan Ophthalmological Society, Taipei, Taiwan (2006)

    Dr LIU Shou Ping

    Dr LIU Shou Ping

    Principal Investigator

    Email: liu.shou.ping@seri.com.sg

    Dr Liu is working with Antimicrobials against Ocular Pathogens (AMOP) in Biomarkers & Anti-infectives Research Group. Dr Liu’s research interest focus on discovery and development of nature inspired peptides and xanthones small molecules based antibiotics for the treatment of infectious diseases caused by multi-drug resistant pathogens such as P aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA), tuberculosis (TB), candida and fusarium. Dr Liu’s researches works are carried out by the use a combinational approaches of rationale design of molecular drug, solid phase peptide synthesis, organic and medicinal synthesis, microbiology methods, biophysical study, NMR and molecular dynamics (MD) based on our well-established platform from multidisciplinary fields collaborations.

    Other concurrent positions

    • Adjunct Assistant Professor, Duke-NUS Graduate Medical School, SRP in Neuroscience and Behavioral Disorders

    Research Interests

    Development of cationic antimicrobial peptides (AMPs) and small organic molecules including natural compounds and their derivatives based antibiotics for eye and skin infectious diseases; Development of biocidal surface/medical device and implant by approaches of covalently linking or incorporation of antibiotics to surface for artificial cornea implants and other application; Design, synthesis and characterization of new peptides-, polymer-peptide conjugations- and polymer/oligomers- based biomaterials and molecular probes for biomedical application, e.g., conjugated polymers-based fluorescent biosensor for sensing and detection of pathogen, ions, bacterial lipopolysaccharide (LPS), some important bio-macromolecules such as NDA and ATP.

    Education

  • 1997
  • Ph. D.in Polymer Chemistry and Physics Nanjing University of Science and Technology, CHINA
  • 1994
  • Master in Synthetic Medicinal Chemistry China Pharmaceutical University, Nanjing, CHINA
  • 1988
  • Bachelor in Chemistry Jiangxi Normal University, CHINA

    Previous Positions

  • 2008
  • Visiting Scientist at Pharmacy College, Louis Pasteur University, Strasbourg, France
  • 2001
  • Research Fellow with Department of Chemistry, National University of Singapore
  • 1999
  • Group Leader and Senior Scientist, Shanghai Pesticide Research Institute, CHINA
  • 1997
  • Postdoctoral Fellow with Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS)

    Awards

    • 2007 SingHealth Short-Term Fellowship

    Ophthalmology & Scientific Involvement

    • Members, ARVO
    • Reviewer for international scientific journals: Macromolecules, J. Med. Chem., Amino Acids, J. Peptide Sciences, J. Polymer Science: Part A: Polymer Chemistry.

    Patents

    • WO/2013/036207,PCT/SG2012/000328 Derivatives of Xanthone Compounds.
    • WO/2009/131548, MULTIMERIC FORMS OF ANTIMICROBIAL PEPTIDES
    • WO/2007/126392, ANTIMICROBIAL PEPTIDES
    • WO/2007/126391, INVESTIGATION OF MUCOSA DRYNESS CONDITIONS

    Selected publications

    1. Zou H, Koh JJ, Li J, Qiu S, Aung TT, Lin H, Lakshminarayanan R, Dai X, Tang C, Lim FH, Zhou L, Tan AL, Verma C, Tan DT, Chan HS, Saraswathi P, Cao D, Liu S*, Beuerman RW, Design and Synthesis of Amphiphilic Xanthone Based Membrane Targeting Antimicrobials with Improved Membrane Selectivity, Journal of Medicinal Chemistry 2013, 56, 2359-2373 (* Corresponding author) (IF: 5.614)
    2. Koh JJ, Qiu S, Zou H, Lakshminarayanan R, Li J, Zhou X, Tang C, Saraswathi P, Verma C, Tan DT, Tan AL, Liu S*, Beuerman RW, Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane, Biochim Biophys Acta-biomembranes, 2013, 1828(2): 834-44. (IF: 4.111)
    3. Jun Jie Koh, Shouping Liu*, Wennan Zeng, Lingyun Wang, Valiyaveettil Suresh, Derong Cao, Roger Beuerman, Electron donating group substituted and α-D-mannopyranoside directly functionalized polydiacetylenes as a simplified bio-sensing system for detection of Lectin and E. coli, Sensors & Actuators: B. Chemical 2013 178, 563-571 (IF: 3.668)
    4. Shuimu Lin, Shouping Liu, Fengqing Ye, Li Xu, Wennan Zeng, Lingyun Wang, Roger Beuerman and Derong Cao, Sensitive Detection of DNA by Hyperbranched Diketopyrrolopyrrole-based Conjugated Polyelectrolytes, Sensors & Actuators: B. Chemical 2013, 182, 176-183 (IF: 3.668)
    5. Li J, Liu S, Lakshminarayanan R, Bai Y, Pervushin K, Verma C, Beuerman RW., Molecular simulations suggest how a branched antimicrobial peptide perturbs a bacterial membrane and enhances permeability, Biochim Biophys Acta- biomembranes, 2012, 828(3): 1112-1121. (IF: 4.111)
    6. Yang Bai, Shouping Liu, Jianguo Li, Rajamani Lakshminarayanan, Padmanabhan Sarawathi, Charles Tang, Duncun Ho, Chandra Verma, Roger W. Beuerman, Konstantin Pervushin, Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target, Journal of Biological Chemistry, 2012 287(32): 26606-17 (IF: 5.328)
    7. Wennan Zeng, Lingyun Wang, Shouping Liu*, Shuimu Lina, Roger Beuermanc, Derong Cao, Cationic conjugated polyelectrolyte-based sensitive fluorescence assay for adenosinetriphosphate and alkaline phosphatase, Sensors & Actuators: B. Chemical 171– 172 (2012) 652– 657 (IF: 3.668)
    8. Zhou L+, Liu S. P+, Chen L. Y., Li J, Ong L. B., Guo L, Wohland T., Tang, C. C., Lakshminarayanan R, Mavinahalli J, Verma C., Beuerman, R. W. The structural parameters for antimicrobial activity, human epithelial cell cytotoxicity and killing mechanism of synthetic monomer and dimer analogues derived from hBD3 C-terminal region, Amino Acids 2011 40(1):123-33 +Equally contributed to this work (IF: 4.106)
    9. Lin SM, Liu SP, Zou HX, Zeng WN, Wang LY, Beuerman, RW, Cao DR, Synthesis of Diketopyrrolopyrrole (DPP)- Containing Conjugated Polyelectrolytes for Naked-Eye Detection of DNA, Journal of Polymer Science, Part A: Polymer Chemistry, 2011, 49, 3882-3889 (IF: 3.543)
    10. Wennan Zeng, Shouping Liu, Hanxun Zou, Linyun Wang, Roger Beuerman and Derong Cao. A novel cationic conjugated polymer for determinating the binding ability of calf thymus DNA. Journal of Polymer Science, Part A: Polymer Chemistry, 48: 4168-4177, 2010 (IF: 3.543)
    11. Liu SP, Zhou L, Lakshminarayanan R and Beuerman RW, Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities. Review, International Journal of Peptide Research and Therapeutics, 16: 199-213 2010. (IF: 0.986) This review has high citation number of 22 till March 2013.
    12. Liu Shouping, Lei Zhou, C.S. Verma and R.W. Beuerman, Effect of Parameters of Peptides on Disulfide Bond Formation and Highly Oxidized Side Products in the Oxidation of Thiols of Linear Analogs of Human b-Defensin 3 by Dimethyl Sulfoxide, Journal of Peptide Science, 2009, 15, 95-106. (IF: 1.799)
    13. Yang Bai, Shouping Liu, Lei Zhou, Jing Li, Ping Jiang, Charles Tang, Chandra Verma, Yuguang Mu, Roger W. Beuerman, Konstantin Pervushin, Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin, Biochemistry. 2009 48(30):7229-39 (IF: 3.377)
    14. Shouping Liu, Lei Zhou, Jing Li, A. Suresh, C.S. Verma, YongHwee Foo, E.Yap, Donald Tan and R.W. Beuerman, De Novo Linear Analogs of Human -Defensin 3: Concept for Design of Antibacterial Peptides with Reduced Cytotoxicity to Mammalian Cells, ChemBioChem, 2008, 9(6), 964-973. (IF: 3.944)

    Dr Matthew Jason LOVATT

    Dr Matthew Jason LOVATT

    PhD

    Research Scientist

    Email: lovatt.matthew.jason@seri.com.sg

    Dr Matthew Lovatt obtained his PhD from Imperial College London in 1999. He has expertise and experience in Immunology, cell biology, biochemistry and stem cell research. Matthew was previously employed by A*STAR under the guidance of Alan Colman. He was involved in the directed differentiation of human embryonic stem cells towards corneal endothelial cells. He joined SERI in March 2015 and his current research focus is the role of oxidative stress in healthy and diseased corneal endothelial cells.

    Research Interests

    To understand at the cellular and molecular level how oxidative stress is regulated in corneal endothelial cells.

    Education

  • 1999
  • PhD Imperial College London

    Previous Positions

  • 2014-2010
  • Institute of Medical Biology, A*STAR, Singapore
  • 2009-2006
  • King’s College London
  • 2005
  • Imperial College London
  • 2004-1999
  • National Institute of Medical Research, London

    Selected Publications

    1. Young T, Poobalan Y, Tan EK, Tao S, Ong S, Wehner P, Schwenty-Lara J, Lim CY, Sadasivam A, Lovatt M, Wang ST, Ali Y, Borchers A, Sampath K, Dunn NS. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development. 2015;141:3505-3516
    2. Lovatt M, Bijlmakers MJ. Stabilisation of b-catenin downstream of T cell receptor Signalling. PLoS ONE. 2010;5(9)
    3. Akbulut S, Alagarsamy L, Ambardekar C, Canciani B, Kim MK, Vilimas T, Mason J, Basson MA, Lovatt M, Powell J, Quatela S, Phillips M, Licht JD. Sprouty Proteins inhibit receptor-mediated activation of phosphatidylinositol-specific Phospholipase C. Mol Biol Cell. 2010;21(19)
    4. Schneider H, Wang H, Raab M, Valk E, Smith X, Lovatt M, Wu Z, Maqueira-Iglesias B, Strebhardt K, Rudd CE. Adaptor SKAP-55 Binds p21 Activating Exchange Factor RasGRP1 and Negatively Regulates the p21-ERK Pathway in T-Cells. PLoS ONE. 2008;3(3)
    5. Wang H, Liu H, Lu Y, Lovatt M, Wei B, Rudd CE. Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol. 2007;(19):6863-75
    6. Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R. Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. Mol Cell Biol. 2006;26(22):8655-65
    7. Zamoyska R, Lovatt M. Signalling in T-lymphocyte development: integration of signalling pathways is the key. Curr Opin Immunol. 2004;16(2):191-6

    Dr Ryan MAN

    Dr Ryan MAN

    PhD

    Senior Clinical Research Fellow

    Email: man.eyn.kidd.ryan@seri.com.sg

    Dr. Man has been undertaking postdoctoral research for the past three years at the Singapore Eye Research Institute (SERI) as a clinical research fellow. He is interested in the public health aspects of chronic eye diseases, particularly on how to detect and intervene before lasting vision loss occurs.

    He has also published widely in other areas of health services and public health research including risk factors associated with development and progression of eye diseases, the impact of these diseases on health and vision-related quality of life, as well as the effectiveness of behavioral interventions to improve patient outcomes in ophthalmology.

    Other Concurrent Positions

    • Instructor, Office of Clinical Sciences, Duke-NUS Graduate Medical School

    Research Interests

    • Clinical health services and translational eye research
    • Ocular epidemiology
    • Patient-centered outcomes in eye and metabolic disorders

    Education

    • 2014
    PhD in Ophthalmology, University of Melbourne
    • 2008
    1ST Class Honors in Biomedical Science, University of Bradford

    Previous Positions

    • 2006-2010
    Clinical Trial Coordinator, Singapore Eye Research Institute

    Awards

    • 2015
    1st Runner-Up, Best Poster Competition, Innovating Long Term Care Conference
    • 2014
    Association for Research in Vision and Ophthalmology (ARVO) Travel Grant
    • 2010
    Melbourne International Research Scholarship
    • 2010
    Melbourne Fee Remission Scholarship
    • 2008
    Promega Bronze Award

    Ophthalmology & Scientific Involvement

    • Member: Association of Ocular Circulation (AOC)
    • Member-in-Training: Association for Research in Vision and Ophthalmology (ARVO)

     

    Selected publications

    1. Man REK, Veerapan AR, Tan SP, Fenwick E, Sabanayagam C, Chua J, Leong YY, Wong TY, Lamoureux EL, Cheng CY, Tong L. Incidence and risk factors of symptomatic dry eye disease in Asian Malays from the Singapore Malay Eye Study. The Ocular Surface 2017; Oct;15(4):742-748
    2. Man REK, Fenwick E, Sabanayagam C, Li LJ, Tey CS, Soon JTH, Cheung Gemmy, Tan G, Wong TY, Lamoureux EL. Differential Impact of Unilateral and Bilateral Classifications of Diabetic Retinopathy and Diabetic Macular Edema on Vision-Related Quality of Life. Investigative Ophthalmology and Visual Science 2016; Sep 1;57(11):4655-60.
    3. Man REK, Fenwick E, Sabanayagam C, Li LJ, Gupta P, Tham YC, Wong TY, Cheng CY, Lamoureux EL. Prevalence, Correlates, and Impact of Uncorrected Presbyopia in a Multi-Ethnic Asian Population. American Journal of Ophthalmology 2016; Aug; 168:191-200.
    4. Man REK, Sasongko MB, Wang JJ, MacIsaac R, Wong TY, Sabanayagam C, Lamoureux EL. The Association of Estimated Glomerular Filtration Rate with Diabetic Retinopathy and Macular Edema. Investigative Ophthalmology and Visual Science 2015; 56(8):4810-16.
    5. Man REK, Lamoureux EL, Taouk Y, Xie J, Sasongko MB, Best WB, Noonan JE, Kawasaki R, Wang JJ and Luu CD. Axial Length, Retinal Function and Oxygen Consumption: A Potential Mechanism for a Lower Risk of Diabetic Retinopathy in Longer Eyes. Investigative Ophthalmology and Visual Science 2013; 54(12):7691-7698.
    6. Man REK, Sasongko MB, Sanmugasundram S, Nicolaou T, Xie J, Wang JJ, Wong TY, Lamoureux EL. Longer Axial Length Is Protective of Diabetic Retinopathy and Macular Edema. Ophthalmology 2012;119(9):1754-9

    Dr Baskaran MANI

    Dr Baskaran MANI

    MBBS, DO, DNB

    Clinician Scientist

    Email: baskaran.mani@seri.com.sg

    Dr Baskaran Mani, is a clinician scientist in Singapore Eye Research Institute, with special interest in glaucoma. Formerly, a glaucoma specialist from India, he participated in several clinical and epidemiological studies in glaucoma from both India and Singapore.

    Other concurrent positions

    • Assistant Professor, Office of Clinical Sciences, Duke-NUS graduate Medical School

    Research Interests

    Glaucoma – Anterior segment imaging in glaucoma, Epidemiology of glaucoma, IOP – novel devices and correction factors, Clinical trials in angle closure glaucoma, Yoga and eye

    Education

  • 1990
  • MBBS The TamilNadu Dr MGR Medical University, Chennai, India
  • 1996
  • DO Sankara Nethralaya under TN Dr MGR Medical University, India
  • 1998
  • DNB Sankara Nethralaya, Chennai, India

    Previous Positions

  • 1998-2008
  • Consultant, Sankara Nethralaya, Chennai

    Awards

    Nil

    Ophthalmology & Scientific Involvement

    • Member, Editorial Board, ISRN Ophthalmology
    • Scientific Committee member, Singapore Eye Research Institute, Singapore
    • Member, Glaucoma Society of India, India
    • Member, All India Ophthalmological Society, India
    • Associate board member, erstwhile AOGS currently WGC, 2006-2008
    • Organizing committee member, SEAGIG, Chennai 2006

    Selected publications

    1. Tun TA, Baskaran M, Zheng C, Sakata LM, Perera SA, Chan AS, Friedman DS, Cheung CY, Aung T. Assessment of trabecular meshwork width using swept source optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2013 Jun;251(6):1587-92
    2. Ho SW, Baskaran M, Zheng C, Tun TA, Perera SA, Narayanaswamy AK, Friedman DS, Aung T. Swept source optical coherence tomography measurement of the iris-trabecular contact (ITC) index: a new parameter for angle closure. Graefes Arch Clin Exp Ophthalmol. 2013 Apr;251(4):1205-11
    3. Pan CW, Cheung CY, Aung T, Cheung CM, Zheng YF, Wu RY, Mitchell P, Lavanya R, Baskaran M, Wang JJ, Wong TY, Saw SM. Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study. Ophthalmology. 2013 Feb;120(2):284-91.
    4. Kumar RS, Baskaran M, Friedman DS, Xu Y, Wong HT, Lavanya R, Chew PT, Foster PJ, Aung T. Effect of prophylactic laser iridotomy on corneal endothelial cell density over 3 years in primary angle closure suspects. Br J Ophthalmol. 2013 Mar;97(3):258-61.
    5. Tian J, Marziliano P, Baskaran M, Tun TA, Aung T. Automatic segmentation of the choroid in enhanced depth imaging optical coherence tomography images. Biomed Opt Express. 2013 Mar 1;4(3):397-411.
    6. Narayanaswamy A, Zheng C, Perera SA, Htoon HM, Friedman DS, Tun TA, He M, Baskaran M, Aung T. Variations in iris volume with physiologic mydriasis in subtypes of primary angle closure glaucoma. Invest Ophthalmol Vis Sci. 2013 Jan 23;54(1):708-13.
    7. Chong RS, Sakata LM, Narayanaswamy AK, Ho SW, He M, Baskaran M, Wong TY, Perera SA, Aung T. Relationship between Intraocular Pressure and Angle Configuration: An Anterior Segment OCT Study. Invest Ophthalmol Vis Sci. 2013 Mar 5;54(3):1650-5.
    8. Nongpiur ME, Haaland BA, Friedman DS, Perera SA, He M, Foo LL, Baskaran M, Sakata LM, Wong TY, Aung T. Classification algorithms based on anterior segment optical coherence tomography measurements for detection of angle closure. Ophthalmology. 2013 Jan;120(1):48-54.
    9. Xu Y, Liu J, Tan NM, Lee BH, Wong DW, Baskaran M, Perera SA, Aung T. Anterior chamber angle classification using multiscale histograms of oriented gradients for glaucoma subtype identification. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3167-70.
    10. Wong DW, Liu J, Tan NM, Fengshou Y, Cheung C, Baskaran M, Aung T, Wong TY. An ensembling approach for optic cup detection based on spatial heuristic analysis in retinal fundus images. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:1426-9.

    A/Prof Jodhbir MEHTA

    A/Prof Jodhbir MEHTA

    BSc(Hons.), MBBS, FRCOphth, FRCS(Ed),FAMS

    Deputy Executive Director
    Director, Clinical Translational Research
    Head, Tissue Engineering & Stem Cell Research Group
    Co-Head, Cornea & Refractive Research Group

    Email: jodhbir.s.mehta@snec.com.sg

    A/Prof Jod S Mehta joined the faculty as a Clinician Scientist at the Singapore Eye Research Institute (SERI) and a Consultant Ophthalmologist in the Singapore National Eye Centre (SNEC) in 2008. Currently he is Co-Head of Cornea and External Disease and Senior Consultant in the Refractive Service at SNEC and Head of Tissue Engineering and Stem Cell group in SERI. He has academic affiliations with DUKE-NUS GMS and he is also an Adjunct Associate Professor with NUS. A/Prof Mehta received his general ophthalmic training at Moorfields Eye Hospital, London. He also completed a Corneal External disease and Refractive fellowship in Moorfields and at the Singapore National Eye Centre (SNEC). He has won awards at the American Academy of Ophthalmology (AAO), the Association for Research in Vision and Ophthalmology (ARVO) and recently the Nakajima Award at Asia Pacific Academy of Ophthalmology. His corneal interests lie in corneal transplantation – penetrating keratoplasty, lamellar keratoplasty and endothelial keratoplasty, femtosecond laser technology, corneal imaging, corneal infections, corneal refractive surgery, keratoprosthesis surgery, ocular drug delivery systems and corneal genetics. A/Prof Mehta has author of over 170 peer reviewed publications, 9 book chapters and has 6 patents, two of which have been liscenced.

     

    Other concurrent positions

    • Head and Senior Consultant, Corneal and External Eye Disease Service, Singapore National Eye Centre
    • Associate Professor, Duke-NUS Graduate Medical School
    • Adjunct Associate Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS

     

    Research Interests

    My research interests lie in corneal transplantation – penetrating keratoplasty, lamellar keratoplasty and endothelial keratoplasty, femtosecond laser technology, corneal imaging, corneal infections, corneal refractive surgery, cataract surgery, keratoprosthesis surgery and corneal genetics

     

    Education

    • 2013 FAMS Fellow of the Academy of Singapore
    • 2006 FRCS(Ed) Royal College of Surgeons of Edinburgh
    • 2000 MRCOphth Royal College of Ophthalmologist
    • 1995 MBBS Guy’s and St Thomas’ Medical School, University of London
    • 1994 BSc (Hons) Guy’s and St Thomas’ Medical School, University of London

     

    Previous Positions

    • 1999 Moorfields Eye Hospital, London, UK

     

    Awards

    • 2013 Nakajima Award APAO
    • 2011 International Ophthalmologist Education Award, American Academy of Ophthalmology
    • 2011 American Academy of Ophthalmology, Best Poster, Corneal Section
    • 2011 Carl Zeiss International User Group Meeting, Best Paper
    • 2010 HKVF Asian Pacific Academy of Ophthalmology Travel Grant
    • 2009 AAO Achievement Award 2009

     

    Ophthalmology & Scientific Involvement

    • Member AAO, ESCRS, EuCornea, ACS, ARVO, SSO, RCO,RCS (Ed)
    • Examiner Royal College of Surgeons Edinburgh

     

    Selected publications

    1. Peh GS, Toh KP, Ang HP, Seah XY, George BL, Mehta JS. Optimization of human corneal endothelial cell culture: density dependency of successful cultures in vitro. BMC Res Notes. 2013 May 3;6:176.
    2. Han SB, Ang H, Balehosur D, Peh G, Chaurasia SS, Tan DT, Mehta JS. A mouse model of corneal endothelial decompensation using cryoinjury. Mol Vis. 2013 Jun 5;19:1222-30.
    3. Ang M, Chong W, Huang H, Tay WT, Wong TY, He MG, Aung T, Mehta JS. Comparison of anterior segment optical tomography parameters measured using a semi-automatic software to standard clinical instruments. PLoS One. 2013 Jun 4;8(6):e65559.
    4. Zhang T, Yam GH, Riau AK, Poh R, Allen JC, Peh GS, Beuerman RW, Tan DT, Mehta JS. The effect of amniotic membrane de-epithelialization method on its biological properties and ability to promote limbal epithelial cell culture. Invest Ophthalmol Vis Sci. 2013 Apr 30;54(4):3072-81.
    5. Tan XW, Hartman L, Tan KP, Poh R, Myung D, Zheng LL, Waters D, Noolandi J, Beuerman RW, Frank CW, Ta CN, Tan DT, Mehta JS. In vivo biocompatibility of two PEG/PAA interpenetrating polymer networks as corneal inlays following deep stromal pocket implantation. J Mater Sci Mater Med. 2013 Apr;24(4):967-77.
    6. Petznick A, Chew A, Hall RC, Chan CM, Rosman M, Tan D, Tong L, Mehta JS. Comparison of corneal sensitivity, tear function and corneal staining following laser in situ keratomileusis with two femtosecond laser platforms. Clin Ophthalmol. 2013;7:591-8.
    7. Liu YC, Peng Y, Lwin NC, Wong TT, Venkatraman SS, Mehta JS. Optimization of subconjunctival biodegradable microfilms for sustained drug delivery to the anterior segment in a small animal model. Invest Ophthalmol Vis Sci. 2013 Apr 9;54(4):2607-15.
    8. Ang M, Mohamed-Noriega K, Mehta JS, Tan D. Deep anterior lamellar keratoplasty: surgical techniques, challenges, and management of intraoperative complications. Int Ophthalmol Clin. 2013 Spring;53(2):47-58.
    9. Chung HW, Mehta JS. Fibrin glue for Gundersen flap surgery. Clin Ophthalmol. 2013;7:479-84.
    10. Liu YC, Wong TT, Mehta JS. Intraocular lens as a drug delivery reservoir. Curr Opin Ophthalmol. 2013 Jan;24(1):53-9.

    Prof Dan MILEA

    Prof Dan MILEA

    MD, PhD

    Head, Visual Neurosciences Research Group

    Email: dan.milea@snec.com.sg

    Professor Dan Milea is the Head of the Visual Neuroscience Group at SERI and a Senior Clinician in the Neuro-Ophthalmology Department, at the Singapore National Eye Centre. He holds a MD and a PhD in Neuroscience from the University of Pierre et Marie Curie, Paris, France, and has specialized in Neuro-Ophthalmic conditions. After being a consultant at the Pitie-Salpetriere Hospital in Paris (2003-2005), he became a Professor of Neuro-Ophthalmology and consultant at the Glostrup University Hospital in Copenhagen, Denmark (2005-2009) and later, Chairman and Professor of Ophthalmology at the Angers University Hospital in France (2009-2012), prior to joining SERI. He has extensive publications in ophthalmology, neurology and neuroscience in peer-reviewed journals and has been a Principal Investigator for several studies in France, Denmark and Singapore, focusing on hereditary optic neuropathies, non-visual functions of the retina and ocular motor behaviour.

    Professor Milea is also a member of the faculty staff at Duke-NUS, being actively involved in developing our research programme in Visual Neuroscience, as well as our teaching programme in Neuro-Ophthalmology. He has participated at over 150 national and international academic teaching courses, in Europe and Asia, and has published several books and book chapters in Neuro-Ophthalmology. He has trained several fellows in Neuro-Ophthalmology, in France, Denmark and since 2013, in Singapore.

    Other Concurrent Positions

    • Senior Clinician, Neuro-Ophthalmology Department, Singapore National Eye Centre
    • Professor, Duke-NUS, Neuroscience and Behavioral Disorders, Singapore
    • Professor of Ophthalmology, Ophthalmology Department, Angers, France

    Research Interests

    Visual Neuroscience and Clinical Research in Neuro-Ophthalmology: Optic Neuropathies, Pupillary and Circadian dysfunctions in Ophthalmic Conditions, Neurobiology of Ocular Morphogenesis, Melanopsin expressing intrinsically photosensitive retinal ganglion cells, Hereditary Optic Neuropathies, Eye Movement Disorders, Intracranial Hypertension

    Education

  • 1986-1992
  • Medical School, Pitie-Salpetriere, Paris, France
  • 1994-1998
  • Residency, Ophthalmology, Lyon, France
  • 1998-2000
  • Fellowship in Neuro-Ophthalmology, Pitie-Salpetriere, Paris, France
  • 2003
  • PhD, Neuroscience (Brain, Cognition, Behaviour), Pierrre et Marie Curie, Paris, France

    Previous Positions

  • 1998-2000
  • Fellow, Neuro-ophthalmology, Pitié-Salpêtrière University Hospital, Paris, France
  • 2003-2005
  • Consultant, Pitié-Salpêtrière University Hospital, Paris, France
  • 2005-2009
  • Professor of Neuro-Ophthalmology and Consultant, Glostrup University Hospital, Copenhagen, Denmark
  • 2009-2012
  • Chairman and Professor of Ophthalmology, Angers University Hospital, France

    Ophthalmology & Scientific Involvement

    • Member, European Neuro-Ophthalmology (EUNOS) Education Committee
    • Review Editor, Neuro-Ophthalmology
    • Member, Editorial Board, Journal Français d’Ophtalmologie

    Selected publications

    1. Annweiler C, Milea D, Whitson HW, Cheng CY, Wong TY, Ikram K, Lamoureux EL, Sabanayagam C. Vitamin D insufficiency and cognitive impairment in Asians: a multi-ethnic population-based study and meta-analysis. Journal of Internal Medicine, 2016, in press.
    2. Rukmini AV, Milea D, Baskaran M, How AC, Perera SA, Aung T, Gooley JJ. Pupillary Responses to High-Irradiance Blue Light Correlate with Glaucoma Severity. Ophthalmology. 2015;122(9):1777-85.
    3. Milea D, Aung T. Flavonoids and glaucoma: revisiting therapies from the past. Graefes Arch Clin Exp Ophthalmol. 2015;253(11):1839-40
    4. Uro M, Beauchet O, Cherif M, Graffe A, Milea D, Annweiler C. Age-Related Vitamin D Deficiency Is Associated with Reduced Macular Ganglion Cell Complex: A Cross-Sectional High-Definition Optical Coherence Tomography Study. PLoS One. 2015 Jun 19;10(6):e0130879.
    5. Nissen C, Rönnbäck C, Sander B, Herbst K, Milea D, Larsen M, Lund-Andersen H. Dissociation of Pupillary Post-Illumination Responses from Visual Function in Confirmed OPA1 c.983A > G and c.2708_2711delTTAG Autosomal Dominant Optic Atrophy. Front Neurol. 2015 Feb 4.
    6. Ebran JM, Milea D, Trelohan A, Bonicel P, Hamel JF, Leftheriotis G, Martin L. New insights into the visual prognosis of pseuoxanthoma elasticum. Br J Ophthalmol , 2014.
    7. Ronnbaeck C, Milea D, Larsen M. Imaging of the macula indicates early completion of structural deficit in autosomal-dominant optic atrophy. Ophthalmology, 2013 Dec;120(12):2672-7.
    8. Herbst K, Sander B, Lund-Andersen H, Wegener M, Hannibal J, Milea D. Unilateral anterior ischemic optic neuropathy: chromatic pupillometry in affected, fellow non-affected and healthy control eyes. Front Neurol. 2013 May 10.
    9. Lebranchu P, LeMeur G, Magot A, David A, Verny C, Weber M, Milea D. Maculopathy and Spinocerebellar Ataxia Type I: a new association ? J Neuro-Ophthalmol, 2013, Apr 11.
    10. Leruez S, Milea D, Defoort-Dhellemmes S, Colin E, Crochet M, Procaccio V, Ferre M, Lamblin J, Drouin J, Vincent-Delorme C, Lenaers G, Blanchet C, Juul G, Larsen M, Verny C, Reynier P, Amati-Bonneau P, Bonneau D. Sensorineural hearing loss in OPA1-linked disorders. Brain, 2013, Feb 13.
    11. Lenaers G, Hamel G, Delettre C, Amati-Bonneau P, Procaccio V, Bonneau D, Reynier P, Milea D. Dominant Optic atrophy. Orphanet J Rare Dis, 2013 Mar;36(3):e49-53.
    12. Graffe A, Annweiler C, Mauget-Faysse M, Beauchet O, Milea D. Association between hypovitaminosis D and late stages of age-related macular degeneration: a case-control study. J Am Geriatr Soc, 2012, Jul;60(7):1367-9.
    13. Lamirel C, Milea D, Cochereau I, Duong MH, Lorenceau J. Impaired saccadic eye movements in primary open-angle glaucoma. J Glaucoma 2012, June 14.
    14. Skau M, Yri H, Sander B, Gerds TA, Milea D, Jensen R. Diagnostic value of optical coherence tomography for intracranial pressure in idiopathic intracranial hypertension. Graefes Arch Clin Exp Ophthalmol 2012 May 18.

    Dr Raymond P. NAJJAR

    Dr Raymond P. NAJJAR

    PhD

    Senior Research Fellow

    Email: raymond.najjar@seri.com.sg

    Dr. Najjar has obtained his PhD in Neuroscience from the University of Lyon, France and did his postdoctoral training at Stanford University, USA. He has a broad background in neuroscience, circadian rhythms, photobiology, and vision and sleep research, with specific training and expertise in key techniques in these fields. He has lead numerous projects in France, the United States and the Antarctic to elucidate the non-image forming impacts of different light configurations on physiology and behavior. Dr Najjar has received several merit awards and was invited to lecture in various international meetings and grand rounds. He has also assumed different teaching responsibilities in sleep and ophthalmology.

     

    Research Interests

    • Visual and non-visual photoreception, Circadian biology, Sleep, Pupillometry, Visual Neurosciences, Cognitive Neurosciences, Lighting design.

     

    Education

    • 2015   Postdoctoral Research Fellow, Stanford University, USA
    • 2012   Ph.D, Neuroscience, Claude Bernard University Lyon 1, France
    • 2008   M.Sc, Neuroscience, Claude Bernard University Lyon 1, France

     

    Previous Positions

    • Postdoctoral Research Fellow, Stem Cell and Brain Research Institute, France
    • Postdoctoral Research Fellow, Stanford University, USA
    • Research Fellow, Claude Bernard University Lyon 1, France
    • Lecturer, Claude Bernard University, Lyon 1, France

     

    Awards

  • 2014
  • French Society of Research in Sleep Medicine (SFRMS), Postdoctoral Scholarship
  • 2014
  • Society for Research on Biological Rhythms (SRBR), Research Merit Award
  • 2014
  • Sleep Research Society (SRS), Excellence Award
  • 2012
  • Society for Research on Biological Rhythms (SRBR), Research Merit Award
  • 2011
  • French Federation of the Blind and Visually Impaired (FAF), Research Scholarship
  • 2011
  • XII. Congress of the European Biological Rhythms Society (EBRS), Short Oral Communication Prize
  • 2009
  • XI. EBRS Congress, Poster Prize, Ranked: 1st/223
  • 2008
  • Ministère de l’Enseignement Supérieur et de la Recherche Français, Lyon, France, MENRT Competitive Research Scholarship with honors, Ranked: 1st/21
  • 2007
  • Lebanese University, Lebanon, Honor Award

    Ophthalmology & Scientific Involvement

    • Member, The Association for Research in Vision and Ophthalmology
    • Member, Society for Research on Biological Rhythms (SRBR)
    • Member, Sleep Research Society (SRS)

     

    Selected Publications:

    1. Najjar RP and Zeitzer JM. Temporal integration of light flashes by the human circadian system. Journal of Clinical Investigations, (2016), in press. (JIF: 14.05)
    2. Najjar RP, Wolf L, Taillard J, Schlangen LJM, Salam A, Cajochen, C, Gronfier, C. (2014) Chronic Artificial Blue-Enriched White Light Is an Effective Countermeasure to Delayed Circadian Phase and Neurobehavioral Decrements. PLoS ONE 9: e102827. doi:10.1371/journal.pone.0102827. (JIF: 4.24)
    3. Najjar RP, Chiquet C, Teikari P, Cornut PL, Claustrat B, Denis P, Cooper HM, Gronfier C. (2014) Aging of Non-visual Spectral Sensitivity to Light in Humans: Compensatory Mechanisms?, PLoS ONE, 9(1): e85837. doi:10.1371/journal.pone.008. (JIF: 4.24)
    4. Daneault V, Vandewalle G, Najjar RP, Mongrain V, Dumont M, Hébert M, and Carrier J. (2013) Age-Related Changes in Circadian Rhythms During Adulthood. The Encyclopedia of Sleep, 3, 113-117. Kushida C.A. (ed.), Waltham, MA: Academic Press.
    5. Teikari P, Najjar RP, Malkki H, Knoblauch K, Dumortier D, Gronfier C, Cooper HM. (2012) An inexpensive Arduino- based LED stimulator system for vision research. J Neurosci Methods, 211 (2): 227-236. (JIF: 2.25)
    6. Teikari P*, Najjar RP*, Knoblauch K, Dumortier D, Cornut PL, Denis P, Cooper HM, Gronfier C. (2012) A refined flicker photometry technique to measure ocular lens density. JOSA A., 29 (11): 2469-2478. (JIF: 1.5). * equal first authorship

    Dr Monisha Esther NONGPIUR

    Dr Monisha Esther NONGPIUR

    MD, MBBS

    Clinician Scientist

    Email: monisha.esther.nongpiur@seri.com.sg

    Monisha Nongpiur, a Clinician Scientist at the Singapore Eye Research institute (SERI) is actively involved in glaucoma-related clinical and genetics research.

    Other concurrent positions

    • Adjunct Instructor, Duke-NUS

    Research Interests

    Her research is mainly focused on ocular imaging, development of risk assessment models for angle closure glaucoma, and understanding the genetic basis of the disease.

    Education

    • 2007
    MD Ophthalmology All India Institute of Medical Sciences, AIIMS, New Delhi, India.
    • 2002
    MBBS Christian Medical College and Hospital, Vellore, India.

    Awards

    • 2012
    ARVO Travel Grant Award.
    • 2012
    Best Oral Presentations Award, 2nd Annual Graduate Scientific Congress, NUS, Singapore
    • 2011
    Best Paper Presentation Award (2nd Runner-up) at the NUHS Ophthalmology Research Day, Singapore.
    • 2009
    Best Paper NHG Eye Institute 2nd International Ophthalmology Congress, Singapore.

    Ophthalmology & Scientific Involvement

    • Reviewer: Ophthalmology and Investigative Ophthalmology and Visual Science
    • Member: Delhi Ophthalmological Society

    Selected publications

    1. Vithana EN*, Khor CC*, Qiao C, Nongpiur ME, ……….Wang N, Aung T et al. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nature Genetics. 2012 Aug 26. [Epub ahead of print] (IF:35.532)
    2. Nongpiur ME, Haaland BA, Friedman DS, et al. Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure. Ophthalmology, 2012 Sep 22. [Epub ahead of print] (IF:5.017)
    3. Cornes BK*, Khor CC*, Nongpiur ME*, Xu L, et al. (*Equal contribution). Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations. Hum Mol Genet. 2012;21:437-45. (IF: 8.058)
    4. Nongpiur ME, Sakata LM, Friedman DS, et al. Novel Association of Smaller Anterior Chamber Width with Angle Closure in Singaporeans. Ophthalmology 2010;117:1967-73. (IF:5.017)
    5. Foo LL, Nongpiur ME, Allen JC, et al. Determinants of Angle Width in Chinese Singaporeans. Ophthalmology. 2012;119:278-82 (IF:5.017)
    6. Sng CC, Foo LL, Cheng CY, Allen JC, He M , Krishnaswamy G, Nongpiur ME, Friedman DS, Wong TY, Aung T. Determinants of Anterior Chamber Depth: the Singapore Chinese Eye Study. Ophthalmology. 2012;119:1143-50 (IF:5.017)
    7. Nongpiur ME, Ku JY, Aung T. Angle closure glaucoma: a mechanistic review. Curr Opin Ophthalmol. 2011;22:96-101 (IF: 2.429)
    8. Nongpiur ME, He MG, Amerasinghe N, Friedman DS, et al. Lens Vault, Thickness and Position in Chinese Subjects with Angle Closure. Ophthalmology- 2011;118:474-9. (IF:5.017)
    9. Wu RY, Nongpiur ME, He MG, et al. Association of Narrow Angles with Anterior Chamber Area and Volume Measured with Anterior Segment Optical Coherence Tomography. Arch Ophthalmol 2011;129:569-74 (IF:3.516)
    10. Vithana EN, Nongpiur ME, Venkataraman D, Chan SH, Mavinahalli J, Aung T. Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population Molecular Vision 2010; 16:1640-1645 (IF: 2.511)
    11. Nongpiur ME, Wong TY, Sabanayagam C, Lim SC, Tai ES, Aung T. Chronic kidney disease and intraocular pressure: the Singapore Malay Eye Study. Ophthalmology. 2010;117:477-83 (IF:5.017)

    Dr Gary PEH

    Dr Gary PEH

    PhD

    Junior Principal Investigator

    Email: gary.peh.s.l@seri.com.sg

    Research Interests

    • Cell biology – cultivated primary human corneal endothelial cells (HCECs)
    • Tissue-engineering – development of alternate graft material using cultivated HCECs
    • Stem cell biology – human embryonic stem cells (Early neural differentiation)

    Education

  • 2008
  • Doctoral of Philosophy Monash University, Monash Institute of Medical Research / Australian Stem Cell Center, Australia
  • 2001
  • Graduate Diploma Monash University, Monash Institute of Medical Research / Monash Medical Center, Australia
  • 2000
  • Bachelor of Science Monash University, Australia

    Previous Positions

  • 2008
  • Post-Doctoral Research Fellow, Human Embryonic Stem Cell Laboratory, Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

    Awards

  • 2011
  • ARVO international Travel Grant
  • 2005
  • Australian Stem Cell Centre Small Research Grant
  • 2004
  • Australian Stem Cell Centre Travel / Conference Grant
  • 2003
  • Commonwealth-funded higher degree by research (Research Training Scheme)

    Ophthalmology & Scientific Involvement

    • Member, The Association for Research in Vision and Ophthalmology
    • Member, Stem Cell Society Singapore
    • Member, The Australasian Society for Stem Cell Research

    Selected publications

    1. Zhenzhi Chng, Gary SL Peh, Wishva B Herath, Kah-Peng Toh, Heng-Pei Ang, Paul Robson, Jodhbir S Mehta and Alan Colman. High throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells. PLoS ONE. 8(7):e67546. Epub 2013 Jul 2.
    2. Yuen-Kuen Cheong, Zhixian Ngoh, Gary SL Peh, Heng-Pei Ang, Xin-Yi Seah, Zhenzhi Chng, Alan Colman, Jodhbir S Mehta, William Sun. (2013). Identification of cell surface markers Glypican-4 and CD200 that differentiate human corneal endothelium from stromal fibroblast. Invest Ophthalmol Vis Sci. 54(7):4538-4547. Epub 2013 Jul 8.
    3. Gary SL Peh, Kah-Peng Toh, Heng-Pei Ang, Xin-Yi Seah, Benjamin L George, Jodhbir S Mehta. (2013). Optimization of human corneal endothelial cell culture: Density dependency of successful cultures in vitro. BMC Res Notes. 6(1):176. Epub 2013 May 3.
    4. Hannah J Levis, Gary SL Peh, Kah-Peng Toh, Rebekah Poh, Alex J Shortt, Rosemary AL Drake, Jodhbir S Mehta and Julie T Daniels. (2012). Plastic compressed collagen as a novel carrier for expanded human corneal endothelial cells for transplantation. PLoS ONE. 7(11):e50993. Epub 2012 Nov 30.
    5. Gary SL Peh, Man-Xin Lee, Fei-Yi Wu, Kah-Peng Toh, Deepashree Balehosur, Jodhbir S Mehta. (2012). Optimization of human corneal endothelial cells for culture: the removal of corneal stromal fibroblast contamination using magnetic cell separation. International Journal of Biomaterials. 2012:601302. Epub 2012 Jan 12.
    6. Gary SL Peh, Kah-Peng Toh, Fei-Yi Wu, Donald T Tan, Jodhbir S Mehta. (2011). Cultivation of human corneal endothelial cells isolated from paired donor corneas. PLoS ONE. 6(12): e28310. Epub 2011 Dec 16.
    7. Gary SL Peh, Roger W Beuerman, Alan Colman, Donald T Tan, Jodhbir S Mehta. (2011). Human corneal endothelial cell expansion for corneal endothelium transplantation: an overview. Transplantation. 91(8): 811-819.
    8. Fong Chui Yee, Gary SL Peh, Kalamegam Gauthaman, Ariff Bongso. (2009). Separation of SSEA-4 and TRA-160 labelled undifferentiated human embryonic stem cells from a heterogeneous cell population using magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS). Stem Cell Reviews and Reports. 5(1): 72-80.
    9. Gary SL Peh, Richard Lang, Martin F Pera, Susan M Hawes. (2009). CD133 expression by neural progenitors derived from human embryonic stem cells and its use for their prospective isolation. Stem Cells and Development. 18(2): 269-282.
    10. Alice Pébay, Raymond CB Wong, Stuart M Pitson, Ernst J Wolvetang, Gary SL Peh, Adam Filipczyk, Karen LL Koh, Irene Tellis, Linh TV Nguyen, Martin F Pera. (2005). Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. Stem Cells. 23(10): 1541-1548.

    Adj. A/Prof Shamira PERERA

    Adj. A/Prof Shamira PERERA

    B.Sc.(Hons), M.B.B.S.(Hons), FRCOphth

    Co-Head, Bioengineering & Devices Research Group

    Email: shamira.perera@snec.com.sg

    Adj Assoc Prof Shamira Perera qualified from United Medical and Dental Schools of Guy’sand St Thomas’s, University of London, with a BSc(hons) in Biochemistry First Class honours (1994) and MBBS(hons) in 1997. Whilst there, he won the Planck prize for Medicine, a Special Trustees award for BSc funding and a distinction in Obstetrics and Gynaecology.

    An Anterior Segment Fellowship in Brighton and Sussex University Hospital complemented his experience working as a Glaucoma fellow at Southampton and Portsmouth hospitals and Moorfields Eye Hospital (London). In April 2008, he made the move to Singapore with his family.

    Supported by both competitive research grants and industry collaborations: his main interests have lead to 4 patents. Beyond this, he is a panelist for A*STAR’s DxD hub which seeks to advance promising commercializations in MedTech. Adj Assoc Prof Perera has been an invited lecturer for over 23 conferences and reviews manuscripts for the 5 main ophthalmic journals. Together with 3 book chapters, a selection of his peer reviewed publications are listed below from a total of >60.

    Other concurrent positions

    • Senior Consultant, Glaucoma Service, SNEC, Singapore
    • Adjunct Clinical Senior Lecturer, Yong Loo Lin School of Medicine, NUS, Singapore
    • Head of Department for Ophthalmic Investigation Technologists Staff
    • Core faculty for the SingHealth Ophthalmology Residency Programme

    Research Interests

    Ocular imaging, cataract surgery, glaucoma, lasers, glaucoma surgery

    Education

  • 2007
  • FRCOphth Royal College of Ophthalmologists
  • 1997
  • M.B.B.S.(Hons) University of London
  • 1994
  • B.Sc.(Hons) University of London

    Previous Positions

  • 2004
  • Chairman of the Ophthalmic Trainees Group of the Royal College of Ophthalmologists, UK
  • 2006
  • Vice Chair of the Junior Academy of Medical Royal Colleges, UK
  • 2011
  • Treasurer. Singapore Society of Ophthalmologists

    Awards

  • 2013
  • 2nd prize (poster category) Malaysia-Singapore Joint Ophthalmic Congress, KL
  • 2011
  • 3rd Prize at ESCRS Film Festival. Special cases.
  • 2011
  • SingHealth Silver award for Service Quality
  • 2010
  • SNEC Outstanding teacher/mentor award 2010
  • 2009
  • Excellent Service Award EXSA Silver award
  • 2009
  • Asia ARVO travel award
  • 1997
  • The Planck Prize in Medicine
  • 1995
  • Distinction in Obstetrics and Gynaecology

    Ophthalmology & Scientific Involvement

  • 2011
  • Associate Editor for Proceedings of Singapore Healthcare
  • 2013
  • Secretary for the Singapore Society of Ophthalmologists
  • 2014
  • Panelist for A*STAR’s DxD hub

    Selected publications

    1. Ho SW, Baskaran M, Zheng C, Tun TA, Perera SA, Narayanaswamy AK, Friedman DS, Aung T. Swept source optical coherence tomography measurement of the iris-trabecular contact (ITC) index: a new parameter for angle closure. Graefes Arch Clin Exp Ophthalmol. 2013 Apr;251(4):1205-11.
    2. Wang B, Aung T, Marella M, Zheng Y, Wong TY, Perera S, Wong TT, Ho CL, Lamoureux EL. Impact of bilateral open and closed-angle glaucoma on glaucoma-specific functioning in Asians. J Glaucoma. 2013 Apr-May;22(4):330-5.
    3. Tun TA, Baskaran M, Zheng C, Sakata LM, Perera SA, Chan AS, Friedman DS, Cheung CY, Aung T. Assessment of trabecular meshwork width using swept source optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2013 Jun;251(6):1587-92.
    4. Ho H, Chew PT, Sng C, Huang H, Aung T, Perera SA. A comparison of two approaches to managing acute primary angle closure in Asian eyes. Clin Ophthalmol. 2013;7:1205-10.
    5. Guzman CP, Gong T, Nongpiur ME, Perera SA, How AC, Lee HK, Cheng L, He M, Baskaran M, Aung T. Anterior segment optical coherence tomography parameters in subtypes of primary angle closure. Invest Ophthalmol Vis Sci. 2013 Aug 7;54(8):5281-6.
    6. Narayanaswamy A, Perera SA, Htoon HM, Hoh ST, Seah SK, Wong TT, Aung T. Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year. Clin Experiment Ophthalmol. 2013 Aug;41(6):552-60.
    7. Nongpiur ME, Wei X, Xu L, Perera SA, Wu RY, Zheng Y, Li Y, Wang YX, Cheng CY, Jonas JB, Wong TY, Vithana EN, Aung T, Khor CC. Lack of association between primary angle-closure glaucoma susceptibility Loci and the ocular biometric parameters anterior chamber depth and axial length. Invest Ophthalmol Vis Sci. 2013 Aug 27;54(8):5824-8.
    8. Baskaran M, Ho SW, Tun TA, How AC, Perera SA, Friedman DS, Aung T. Assessment of circumferential angle-closure by the iris-trabecular contact index with swept-source optical coherence tomography. Ophthalmology. 2013 Nov;120(11):2226-31. Epub 2013 Jun 14.
    9. Nongpiur ME, Gong T, Lee HK, Perera SA, Cheng L, Foo LL, He M, Friedman DS, Aung T. Subgrouping of primary angle-closure suspects based on anterior segment optical coherence tomography parameters. Ophthalmology. 2013 Dec;120(12):2525-31. Epub 2013 Aug 2.
    10. Xu Y, Liu J, Cheng J, Lee BH, Wong DW, Baskaran M, Perera S, Aung T. Automated anterior chamber angle localization and glaucoma type classification in OCT images. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:7380-3.

    A/Prof Charumathi SABANAYAGAM

    A/Prof Charumathi SABANAYAGAM

    Senior Clinician Scientist
    Deputy Head, Ocular Epidemiology Research Group

    Email: charumathi.sabanayagam@seri.com.sg

    Dr. Charumathi Sabanayagam, a Senior Clinician Scientist and an epidemiologist is a member of the Singapore Epidemiology of Eye Diseases (SEED) unit at the Singapore Eye Research Institute. She received her undergraduate medical degree from University of Madras, and postgraduate degree from The Tamilnadu Dr MGR Medical University, India and a Masters in Public Health and PhD from the National University of Singapore. She completed her postdoctoral research in diabetes and cardiovascular epidemiology at University of West Virginia, USA.

    Other concurrent positions

    • Assistant Professor, Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore
    • Adjunct Assistant Professor, Department of Ophthalmology, National University of Singapore

    Research Interests

    Epidemiology of chronic kidney disease, diabetes and metabolic syndrome Link between renal and retinal diseases, in particular, diabetic retinopathy, and age-related macular degeneration Role of novel biomarkers such as retinal microvascular abnormalities, sleep, and vitamin D in renal and retinal diseases

    Education

    • 1985
    M.B.B.S. University of Madras, India
    • 1998
    MD The Tamilnadu Dr. M.G.R. Medical University, Chennai, India
    • 2006
    M. Med (PH) National University of Singapore
    • 2010
    PhD National University of Singapore

    Previous Positions

    • 2010
    Postdoctoral Research Fellow, West Virginia University School of Medicine, USA
    • 2009
    Postdoctoral Research Fellow, Singapore Eye Research Institute
    • 2006
    Research Fellow, Department of Community, Occupational and Family Medicine, NUS
    • 1987
    Medical Officer/ Lecturer, Raja Muthiah Medical College, Tamil Nadu, India
    • 1986
    Resident Physician, Krishna Hospital, India

    Awards

    • 2009
    Merit award, best oral presentation, medical disciplines, National Healthcare Group, Annual Scientific Congress (NHG-ASC)
    • 2009
    NUS President Graduate Fellowship

    Ophthalmology & Scientific Involvement

    • Associate Editor, BMC- Public Health
    • Member, Editorial Board, Journal of Community Medicine and Health Education
    • Member, Association for Research and Vision in Ophthalmology, USA
    • Member, American Society of Nephrology, USA

     

    Selected publications

    1. Sabanayagam C, Shankar A, Koh D, Chia KS, Saw SM, Lim SC, Tai ES, Wong TY. Retinal microvascular caliber and chronic kidney disease in an Asian population. Am J Epidemiol. 2009;169(5):625-632.
    2. Sabanayagam C, Liew G, Tai ES et al. Relationship between glycated haemoglobin and microvascular complications: is there a natural cut-off point for the diagnosis of diabetes? Diabetologia 2009; 52(7):1279-8.
    3. Sabanayagam C, Lee J, Shankar A, Lim SC, Wong TY, Tai ES. C-reactive protein and microalbuminuria in a multi-ethnic Asian population, Nephrol Dial Transplant. 2010; 25(4): 1167-72.
    4. Sabanayagam C, Wong TY, Lim SC, Lee J, Shankar A, Tai ES. Ethnic disparities in prevalence and risk factors of chronic kidney disease. Nephrol Dial Transplant. 2010; 25(8):2564-70.
    5. Sabanayagam C, Shankar A, Lim SC, Lee J, Tai ES, Wong TY. Serum C-reactive protein level and prediabetes in two Asian populations. Diabetologia. 2011; 54(4):767-75.
    6. Sabanayagam C, Shankar A. Association between sleep duration and cardiovascular disease among US adults. Sleep. 2010;33(8):1037-42.
    7. Sabanayagam C, Wang JJ, Mitchell P, Tan AG, Tai ES et al. Metabolic syndrome components and age-related cataract: The Singapore Malay Eye Study. Invest Ophthalmol Vis.Sci. 2011;52(5):2397-404.
    8. Shankar A, Sabanayagam C, Kalidindi S. Serum 25-hydroxyvitamin D levels and prediabetes among subjects free of diabetes. Diabetes care. 2011; 34(5):1114-9.
    9. Sabanayagam C, Shankar A, Klein BK, Lee KE, Muntner P et al. Bidirectional association of retinal vessel diameters and estimated glomerular filtration rate decline: The Beaver Dam CKD Study. Am J Kidney Dis.2011;57(5):682-91.
    10. Sabanayagam C, Wong TY, Xiao J, Shankar A. Serum cystatin C and prediabetes in non-obese US adults. Eur J Epidemiol.2013;28(4):311-6

    Prof SAW Seang Mei

    Prof SAW Seang Mei

    PhD MPH JohnsH, MBBS NUS

    Co-Head, Myopia Research Group

    Email: saw.seang.mei@seri.com.sg

    Prof Saw Seang Mei is currently a Professor at the Department of Epidemiology and Public Health, and Vice-Dean (Research), Yong Loo Lin School of Medicine, National University of Singapore. She received her MBBS degree from the National University of Singapore and both her MPH and PhD from the Johns Hopkins Bloomberg School of Public Health. Her main teaching area is in Epidemiology, Research Skills and Biostatistics. Seang Mei is the Principal Investigator of the Singapore Cohort study Of the Research factors for Myopia (SCORM), the STrabismus, Amblyopia and Refractive error study in Singapore preschool children (STARS) and the birth cohort, Growing Up in Singapore Towards Healthy Outcomes (GUSTO). Her primary research interests are related to the epidemiology, genetics and gene-environment interactions for myopia and other eye diseases. She has published more than 200 peer-reviewed international journals, including the Lancet and Journal of the American Medical Association (JAMA), and currently is the PI and Co-I of grants totaling > $15 million from the BMRC, NMRC, NIH and NHMRC (Australia). She supervises 30 research staff, 3 post-doctoral research fellows and 6 PhD and MSc students.

    Seang Mei is an Editorial Board member of Investigative Ophthalmology and Visual Science, Ophthalmic and Physiologic Optics, and the Annals Academy of Medicine (Singapore). She is the recipient of the Jeans Coombs Award Johns Hopkins School of Hygiene and Public Health (1998), the Geshin Mohn ARVO Travel Grant (2002), the Edward Clarence Dyason Universitis 21 Award (2005), the Garland W. Clay Award (2006), the Great Women of our Times Awards, Science and Technology Category, Singapore (2006), the American Academy of Ophthalmology (AAO) Achievement Award (2009) and the NUS School of Medicine Faculty Research Excellence Award (2009). Seang Mei was the past Chair of the 11th International Myopia Conference held from 16th to 18th August, 2006 in Singapore, and is past Chair (2010) of the Program Committee, Clinical/Epidemiologic section, Association for Research in Vision and Ophthalmology (ARVO).

    Other concurrent positions

    • Professor/ Vice-Dean (Research), Yong Loo Lin School of Medicine, National University of Singapore
    • Adjunct investigator, A*STAR, Singapore Institute of Clinical Sciences (SICS)
    • Joint appointment, Department of Ophthalmology, National University Hospital
    • Joint appointment, Duke-NUS Graduate Medical School

    Research Interests

    Cohorts and Clinical trials. Epidemiology and gene-environment interaction for eye and other chronic diseases.

    Education

  • 1988
  • MBBS National University of Singapore
  • 1995
  • MPH Johns Hopkins University, Baltimore, USA
  • 1998
  • PhD Johns Hopkins University, Baltimore, USA
  • 2001
  • FAMS Academy of Medicine, Singapore
  • 2012
  • FARVO Association For Research In Vision and Ophthalmology

    Previous Positions

    • Professor, Saw Swee Hock School of Public Health
    • Vice Dean (Research), Yong Loo Lin School of Medicine
    • Adjunct investigator, Singapore Institute of Clinical Sciences (SICS)
    • Joint appointment, Department of Ophthalmology, National University of Singapore
    • Joint appointment, Duke-NUS Graduate Medical School

    Awards

  • 2012
  • Fellow Award, Association for Research in Vision and Ophthalmology (ARVO)
  • 2009
  • American Academy of Ophthalmology (AAO) Achievement Award
  • 2009
  • Yong Loo Lin School of Medicine Faculty Researcher Excellence Award
  • 2006
  • Great Women of our Times Award, Science and Technology Category, Singapore

    Ophthalmology & Scientific Involvement

    • Associate Editor, Translational Vision Science and Technology
    • Editorial Board Member, Case Reports in Ophthalmology
    • Editorial Board Member, Asia-Pacific Journal of Ophthalmology
    • Editorial Board Member, Investigative Ophthalmology and Visual Science (IOVS)
    • International Editorial Advisory Board, Ophthalmic and Physiologic Optics

    Selected publications

    1. Saw SM, Hong CY, Chia KS, Stone RA, Tan D. Nearwork and myopia in young children Lancet 2001;357:390.
    2. Chong YS, Liang Y, Gazzard G, Stone RA, Saw SM. Association between breastfeeding and likelihood of myopia in children. JAMA 2005; 293: 3001-2.
    3. Khor WB, Tin A, Saw SM, Wong TY, Tambyah PA, Tan AL, Beuerman R, Lim L, Chan WK, Heng WJ, Lim J, Loh RSK, Lee SB, Tan DTH. An outbreak of contact lens-associated Fusarium keratitis in Singapore. JAMA 2006;295:2867-73.
    4. Saw SM, Chua WH, Hong CY, Wu HM, Chan WY, Chia KS, Stone RA, Tan D. Nearwork in early onset myopia. Invest Ophthalmol Vis Sci 2002;43:332-9.
    5. Saw SM, Tong, L, Chua, WH, Chia KS, Koh D, Tan DT, Katz J. Incidence and progression of myopia in Singaporean school children. Invest Ophthalmol Vis Sci 2005;46:51-57.
    6. Saw SM, Shankar A, Tan SB, Taylor H, Tan DTH, Stone RA, Wong TY. A cohort study of incident myopia in Singapore children. Invest Ophthalmol Vis Sci 2006 May;47(5):1839-44.
    7. Saw SM, Foster PJ, Gazzard G, Friedman D, Hee J, Seah S. Under-corrected refractive error in Singapore Chinese adults: The Tanjong Pagar Survey. Ophthalmol 2004; 111: 2168-2174.
    8. Saw SM, Tan SB, Fung D, Chia KS, Koh D, Tan DTH, Stone RA. IQ and the association with myopia in children. Invest Ophthalmol Vis Sci 2004;45:2943-8.
    9. Li LJ, Ikram MK, Cheung CY, Lee YS, Lee LJ, Gluckman P, Godfrey KM, Chong YS, Kwek K, Wong TY, Saw SM. Effect of maternal body mass index on the retinal microvasculature in pregnancy. Obstet Gynecol. 2012 Sep;120(3):627-35.
    10. Li LJ, Cheung CY, Ikram MK, Gluckman P, Meaney MJ, Chong YS, Kwek K, Wong TY, Saw SM. Blood Pressure and Retinal Microvascular Characteristics During Pregnancy: Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study. Hypertension. 2012 Jul;60(1):223-30.
    11. Morgan IG, Ohno-Matsui K, Saw SM. Myopia. Lancet. 2012; 379(9827):1739-48.
    12. Horikoshi M, Yaghootkar H*, Mook-Kanamori DO*, Sovio U, Taal HR, Hennig BJ, Bradfield JP, …, Mohlke KL, Boomsma DI, Saw SM, Lakka TA, Körner A, Loos RJ, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW, Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, Bønnelykke K, Bisgaard H, Eriksson JG, Widén E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI*, Grant SF*, Jaddoe VW*, Jarvelin MR*, Timpson NJ*, Prokopenko I*, Freathy RM*; Early Growth Genetics (EGG) Consortium. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet. 2013 Jan;45(1):76-82.
    13. Jensen RA, Sim X, Li X, Cotch MF, Ikram MK, Holliday EG, Eiriksdottir G, Harris TB, Jonasson F, Klein BE, Launer LJ, Smith AV, Boerwinkle E, Cheung N, Hewitt AW, Liew G, Mitchell P, Wang JJ, Attia J, Scott R, Glazer NL, Lumley T, McKnight B, Psaty BM, Taylor K, Hofman A, de Jong PT, Rivadeneira F, Uitterlinden AG, Tay WT, Teo YY, Seielstad M, Liu J, Cheng CY, Saw SM, Aung T, Ganesh SK, O’Donnell CJ, Nalls MA, Wiggins KL, Kuo JZ; Blue Mountains Eye Study GWAS Team; CKDGen Consortium, van Duijn CM, Gudnason V, Klein R, Siscovick DS, Rotter JI, Tai ES, Vingerling J, Wong TY. Genome-wide association study of retinopathy in individuals without diabetes. PLoS One. 2013;8(2):e54232.

    Prof Leopold SCHMETTERER

    Prof Leopold SCHMETTERER

    PhD

    Scientific Director
    Head, Ocular Imaging

    Email: leopold.schmetterer@seri.com.sg

    Prof Schmetterer is head of Ocular Imaging at SERI. His interests span a wide range of imaging from development of novel technology towards applications in preclinical research and clinics. Prof Schmetterer is also interested in clinical trials and is involved in many studies in retina, glaucoma, cornea and dry eye.

    He has published more than 280 peer reviewed publications, was invited for more than 200 lectures including more than 15 key note lectures and been awarded more than 15 million Euro in research grant funding. He is a member of the Editorial Boards of Progress in Retinal and Eye Research, Scientific Reports, Acta Ophthalmologica, Journal of Ocular Pharmacology and Therapeutics, Current Eye Research and 5 other journals.

    Other Concurrent Positions

    • Adjunct Professor of Ophthalmology at Lee Kong Chian School of Medicine, Nanyang Technological University
    • Professorship in Vienna on hold (3 years)

    Research Interests

    Imaging, Optical coherence tomography, Ocular blood supply, Clinical trials

    Education

    • 1989
    PhD in Medical Physics, Technical University, Vienna, Austria
    • 1986
    MsC in Technical Physics, Technical University, Vienna, Austria

    Previous Positions

    • 2016
    Head of the Division of Ophthalmic Pharmacology at the Department of Clinical Pharmacology
    • 2016
    Extraordinary professor with Tenure Track at the Center of Medical Physics and Biomedical Engineering (50%) and the Department of Clinical Pharmacology (50%)

    Awards

    • 2016
    Honorary degree from Carol Davila University Bucharest
    • 2015
    Hans Goldmann Medal
    • 2014
    International Bach Lecture, Leipzig
    • 2014
    ARVO Silver Fellow
    • 2011
    Visionary of the Quarter, European Vision Institute
    • 2002
    First prize International MSD award
    • 1998
    Austrian Höchst Award

    Ophthalmology & Scientific Involvement

    • Member of the Executive Board of EU-EYE (Parent Organisation of all European Ophthalmological Societies)
    • President of EVER (European Association for Vision and Eye Research) 2012
    • President of EVER foundation

     

    Selected publications

    1. Leitgeb RA, Werkmeister RM, Blatter C, Schmetterer L. Doppler optical coherence tomography. Prog Retin Eye Res. 2014;41:26-43.
    2. Aranha Dos Santos V, Schmetterer L, Gröschl M, Garhofer G, Schmidl D, Kucera M, Unterhuber A, Hermand JP, Werkmeister RM. In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography.Opt Express. 2015;23:21043-63.
    3. Werkmeister RM, Schmidl D, Aschinger GC, Doblhoff-Dier V, Palkovits S, Wirth M, Garhöfer G, Linsenmeier RA, Leitgeb RA, Schmetterer L. Retinal oxygen extraction in humans. Sci Reports 2015;5:15763.
    4. Palkovits S, Lasta M, Told R, Schmidl D, Werkmeister RM, Popa Cherecheanu A, Garhöfer G, Schmetterer L. Relation of retinal blood flow and retinal oxygen tension during stimulation with diffuse luminance flicker. Sci Reports 2015;5:18291.
    5. Aranha dos Santos V, Schmetterer L, Triggs GJ, Leitgeb RA, Groschl M, Messner A, Schmidl D, Garhofer G, Aschinger G, Werkmeister RM. Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT. Biomed Opt Exp 2016 Jun 16;7(7):2650-70.
    6. Seidel G, Aschinger G, Singer C, Herzog SA, Weger M, Haas A, Werkmeister RM, Schmetterer L, Garhöfer G. Estimating Retinal Blood Flow Velocities by Optical Coherence Tomography.. JAMA Ophthalmol. In press.

    Dr SEET Li Fong

    Dr SEET Li Fong

    DPhil

    Assistant Director, Laboratory Translational Research
    Principal Investigator

    Email: seet.li.fong@seri.com.sg

    Dr Seet attained her DPhil from the University of Oxford, UK in Biochemistry followed by post-doctoral training in Amgen Research Institute, Toronto, Canada and the Institute of Molecular and Cell Biology, A*STAR, Singapore. Prior to joining SERI, she was in the biomedical industry as a group leader in Viacell Singapore Pte Ltd. Her extensive experience in both academia and biopharma research is now directed toward developing next-generation anti-fibrotic compounds for ocular and other fibrotic conditions.

    Other concurrent positions

    • Adjunct Assistant Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine, NUS
    • Adjunct Assistant Professor, Duke-NUS GMS

    Research Interests

    Ocular wound healing, anti-fibrotic drug discovery, prevention of scarring in glaucoma filtration surgery, siRNAs and small molecules as potential anti-fibrotic therapeutics, pterygium cell biology

    Education

  • 1996
  • DPhil University of Oxford, UK
  • 1992
  • 1st Class Hons National University of Singapore

    Previous Positions

  • 2005
  • ViaCell Singapore Pte Ltd, Singapore
  • 1998
  • Institute of Molecular and Cell Biology, Singapore
  • 1996
  • Amgen Research Institute, Toronto, Canada

    Awards

  • 1992
  • EDB-Glaxo human resource development scholarship, Economic Development Board, Singapore
  • 1994
  • Overseas research studentship, Overseas Research Council, U.K
  • 1993
  • Oriel scholarship, Oriel College, Oxford, U.K
  • 2009
  • Merit paper award, 8th NHG Annual Scientific Congress, Singapore

    Ophthalmology & Scientific Involvement

    • Member, Editorial Board, World Journal of Stem Cell
    • Member, Investigative Ophthalmology and Visual Science

    Selected publications

    1. Seet LF, Finger SN, Chu SW, Toh LZ,Tina T. Wong. Novel insight into the inflammatory and cellular responses following experimental glaucoma surgery: a roadmap for inhibiting fibrosis. Curr Mol Med 2013;13:911-928.
    2. Barathi VA, Kwan JL, Tan QS, Weon SR, Seet LF, Goh LK, Vithana EN, Beuerman RW. Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice. Dis Model Mech. 2013 Jun 20. [Epub ahead of print]
    3. Liu J, Seet LF, Koh LW, Venkatraman A, Venkataraman D, Mohan RR, Praetorius J, Bonanno JA, Aung T, Vithana EN. Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line. Invest Ophthalmol Vis Sci 2012;53:3270-3279.
    4. Seet LF, Tong L, Su R, Wong TT. Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium. Invest Ophthalmol Vis Sci 2012;53:587-595.
    5. Seet LF, Su R, Toh LZ, Wong TT. In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon’s fibroblasts: comparisons with mitomycin-C. J Cell Mol Med 2012;16:1245-1259.
    6. Seet LF, Lee WS, Su R,Finger S, Crowston JG, Wong TT. Validation of the glaucoma filtration surgical mouse model for anti-fibrotic drug evaluation. Mol Med 2011;17:557-567.
    7. Siak JJ, Ng SL, Seet LF, Beuerman RW, Tong L. The nuclear-factor kappa B pathway is activated in pterygium. Invest. Ophthalmol Vis Sci 2011;52:230-236.
    8. Riazuddin SA, Vithana EN, Seet LF, Liu Y, Al-Saif A, Koh LW, Heng YM, Aung T, Meadows DN, Eghrari AO, Gottsch JD, Katsanis N. Missense mutations in the sodium borate co-transporter SLC4A11 cause late onset Fuchs corneal dystrophy. Hum Mutat 2010;31:1261-1268.
    9. Wang T, Liu NS, Seet LF, Hong W. The emerging role of VHS domain-containing Tom1, Tom1L1 and Tom1L2 in membrane trafficking. Traffic 2010;11:1119-1128.
    10. Seet LF, Su R, Barathi VA, Lee WS, Poh R, Heng YM, Manser E, Vithana EN, Aung T, Weaver M, Sage EH, Wong TT. SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery. PLoS ONE 2010;5:e9415.
    11. Liu NS, Loo LS, Loh E, Seet LF, Hong W. Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. EMBO J 2009;28:3485-3499.
    12. Seet LF, Teng E, Laning J, Kraus M, Wnendt S, Merchav S, Chan SL. Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum-free conditions. Eur J Haematol 2008;82:124-132.
    13. Chua J, Seet LF, Jiang Y, Su R, Htoon HM, Charlton A, Aung T, Wong TT. Increased SPARC expression in primary angle closure glaucoma iris. Mol Vis 2008;14:1886-92.
    14. Seet LF, Hong W. The Phox (PX) domain proteins and membrane traffic. Biochim Biophys Acta – Mol Cell Biol Lipids 2006;1761:878-96.
    15. Seet LF, Hong W. Endofin can recruit clathrin to early endosomes via TOM1. J Cell Sci 2005;118:575-87.
    16. Wang CC, Ng CP, Lu L, Atlashkin V, Zhang W, Seet LF, Hong W. A Role of VAMP8/Endobrevin in Regulated Exocytosis of Pancreatic Acinar Cells. Dev Cell 2004;7:359-71.
    17. Seet LF, Liu N, Hanson BJ, Hong W. Endofin recruits TOM1 to endosomes. J Biol Chem 2004;279:4670-9.
    18. Seet LF, Hong W. Endofin, an endosomal FYVE domain protein. J Biol Chem 2001;276:42445-54.
    19. Xu Y, Seet LF, Hanson B, Hong W. The Phox homology (PX) domain, a new player in phosphoinositide signaling. Biochem J 2001;360:513-30.
    20. Xu Y, Hortsman H, Seet LF, Wong SH, Hong W. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol 2001;3:658-66.
    21. Seet LF, Cho S, Hessel A, Dumont DJ. Molecular cloning of multiple iosoforms of synaptojanin 2 and assignment of the gene to mouse chromosome 17A2-3.1. Biochem Biophys Res Comm 1998;247:116-22.

    Adjunct Prof Donald TAN Tiang Hwee

    Adjunct Prof Donald TAN Tiang Hwee

    MBBS (S), FRCS(G), FRCS(Ed), FRCOphth, FAMS

    Co-Head, Cornea & Refractive Research Group

    Email: donald.tan.t.h@snec.com.sg

    Donald Tan is the Arthur Lim Professor in Ophthalmology and Senior Advisor of the Singapore National Eye Centre (SNEC), SingHealth, Professor of Ophthalmology at the National University of Singapore, Chair of the Eye Academic Clinical Program at the Duke-NUS GMS, and Medical Director of the Singapore Eye Bank. Involved primarily in clinical and translational research in cornea, refractive surgery and myopia, he has published over 300 peer-reviewed articles (h index = 42), contributed 18 book chapters and holds 13 patents in stem cell culture, myopia prevention, refractive corneal implants and surgical devices for endothelial keratoplasty, and has also trained 28 corneal fellows from 14 countries. He is the recipient of over 20 awards, which include the APAO 2001 De Ocampo Award, the AAO 2006 Distinguished Achievement Award, the ISRS/AAO 2009 Casebeer Award, the Saudi Ophthalmological Society 2010 Gold Medal, the Australia and New Zealand Corneal Society 2011 Doug Coster Award, the Canadian Society of Ophthalmology 2011 W. Bruce Jackson Award, the EuCornea 2012 Medal, the Portland, Oregon Arthur Devers 2012 Lecture, the 2013 Albrecht von Graefe Innovator’s Lecture, and the 2013 Intraocular Implant & Refractive Society of India Gold Medal. . Professor Tan established the Asia Cornea Society in 2007 and the Association of Eye Banks of Asia in 2009, and is currently President of both societies. In 2012 he assumed the Presidency of the US based Cornea Society, its first International President.

    Other concurrent positions

    • Arthur Lim Professor in Ophthalmology and Senior Advisor, Singapore National Eye Centre, SingHealth
    • Senior Consultant, Corneal & External Eye Disease, Singapore National Eye Centre
    • Professor, Department of Ophthalmology, National University Health System

     

    Research Interests

    • Corneal Transplantation Research: anterior lamellar keratoplasty, endothelial keratoplasty, femtosecond laser-assisted keratoplasty, DSAEK and DMEK surgical devices for donor delivery, epidemiological studies, comparative graft survival studies
    • Keratoprosthesis Research: OOKP trials, synthetic OOKP research
    • Tissue engineering: ocular surface epithelia and endothelial cell culture/transplantation
    • Refractive Surgery Research: LASIK, AcuFocus trials, ReLEx trials
    • Infectious Keratitis Research: Asian disease outbreaks, multicentre clinical trials
    • Pterygium Research: surgical trials, EBM studies, epidemiology, etiological studies
    • Myopia Research: epidemiology and environmental risk factors, pharmacological clinical trials on myopia control therapies

     

    Education

    • 1983
    M.B.B.S. Singapore
    • 1988
    F.R.C.S. Glasgow
    • 1989
    F.R.C.Ophth U.K
    • 1994
    F.A.M.S. Singapore
    • 1998
    F.R.C.S. Edinburgh

    Previous Positions

    • 2000
    Director, Singapore Eye Research Institute
    • 2001
    Head, Department of Ophthalmology, National University of Singapore

    Awards

    • 2001
    de Ocampo Award, Asia-Pacific Academy of Ophthalmology (AAO)
    • 2006
    Distinguished Achievement Award, American Academy of Ophthalmology
    • 2006
    Award for Outstanding Performance in Public Health, Minister for Health
    • 2008
    National Outstanding Clinician Scientist Award, National Medical Excellence Awards
    • 2009
    The President’s Science Award
    • 2009
    Casebeer Award, International Society of Refractive Surgery/AAO
    • 2011
    Gold Medal, Saudi Ophthalmological Society
    • 2011
    Doug Coster Award, Australia and New Zealand Corneal Society
    • 2011
    W. Bruce Jackson Award, Canadian Society of Ophthalmology
    • 2011
    SingHealth Excellence Awards – Distinguished Leader Award (Visionary Leader)
    • 2011
    National University of Singapore Medical Faculty Research Excellence Award
    • 2012
    Asia-Pacific Academy of Ophthalmology (AAO) Senior Achievement Award
    • 2012
    EuCornea Medal
    • 2012
    Portland, Oregon Arthur Devers Lecture
    • 2013
    Albrecht von Graefe Innovator’s Lecture
    • 2013
    Intraocular Implant & Refractive Society of India Gold Medal

    Selected publications

    1. Tan DT, Dart JK, Holland EJ, Kinoshita S. Corneal transplantation. Lancet. 2012 May 5;379(9827):1749-61. doi: 10.1016/S0140-6736(12)60437-1. Review.
    2. Chia A, Chua WH, Cheung YB, Wong WL, Lingham A, Fong A, Tan D. Atropine for the Treatment of Childhood Myopia: Safety and Efficacy of 0.5%, 0.1%, and 0.01% Doses (Atropine for the Treatment of Myopia 2). Ophthalmology. 2011 Sep 30. [Epub ahead of print]
    3. Anshu A, Lim LS, Htoon HM, Tan DT. Postoperative risk factors influencing corneal graft survival in the singapore corneal transplant study. Am J Ophthalmol 2011;151:442-448.
    4. Khor WB, Mehta JS, Tan DT. Descemet stripping automated endothelial keratoplasty with a graft insertion device: surgical technique and early clinical results. Am J Ophthalmol 2011;151:223-232.
    5. Yuen LH, Chan WK, Koh J, Mehta JS, Tan DT. A 10-year prospective audit of LASIK outcomes for myopia in 37,932 eyes at a single institution in Asia. Ophthalmology 2010;117:1236-1244.
    6. Loh RS, Chan CM, Ti SE, Lim L, Chan KS, Tan DT. Emerging prevalence of microsporidial keratitis in Singapore: epidemiology, clinical features, and management. Ophthalmology. 2009 Dec;116(12):2348-53.
    7. Donald TH Tan, Prathiba Janardhanan, Huijun Zhou, Yiong-Huak Chan, Hla Myint Htoon, Leonard PK Ang, Laurence S Lim Penetrating Keratoplasty in Asian Eyes – The Singapore Corneal Transplant Study. Am J Ophthalmology 2008 June (Vol 115, No. 6): 975-982
    8. Khor W.B, Aung T., Saw S.M., Wong T.Y., Tambyah P.A., Tan A.L., Beuerman R.W., Lim L., Chan W.K., Heng W.J., Lim J., Loh R.S., Lee S.B., Tan D.T.H. An outbreak of Fusarium keratitis associated with contact lens wear in Singapore. JAMA 2006; 295(24):2867-2873
    9. Chua W.H., Balakrishnan V., Chan Y.H. Tong L., Ling Y., Quah B.L., Tan D.T.H. Atropine for the treatment of childhood myopia. Ophthalmology 2006 Dec ;113(12) :2285
    10. Tan D.T.H., Ang L.P.K, Beuerman R.W. Reconstruction Of The Ocular Surface By Transplantation Of A Serum-Free Derived Cultivated Conjunctival Epithelial Equivalent. Transplantation 2004;77-2291

    Dr Gavin TAN

    Dr Gavin TAN

    MBBS, MMed(Ophth), FRCS(Ed), FAMS

    Clinician Scientist

    Email: gavin.tan@singhealth.com.sg

    Dr Gavin Tan is a surgical and medical vitreoretinal specialist and consultant cataract surgeon with the Retina Centre of the Singapore National Eye Centre(SNEC). He completed multiple vitreo-retinal fellowships at SNEC, the Byer Eye Institute at Stanford University and Jules Stein Eye institute at the University of California Los Angeles. He is actively involved with academic research and leads multiple Clinical Trials at the Singapore Eye Research Institute (SERI). His major clinical and research interest is in the field of diabetic retinopathy.

    He is involved in the development and implementation of a national diabetic retinopathy telemedicine screening program in Singapore and is studying the use of novel approaches including optical coherence tomography, automated detection of retinopathy and personalized screening intervals to improve cost effectiveness and efficacy of diabetic retinopathy screening.

    He hopes to reduce diabetic visual impairment and blindness by improving screening, diagnosis and treatment of diabetic retinopathy with the goal of transforming clinical care and improving patient outcomes.

    Other concurrent positions

    • Consultant, Surgical Retina Dept, Singapore National Eye Centre
    • Assistant Professor, Duke-NUS Graduate Medical School, Singapore
    • Lead, Diabetic complications Singhealth Duke-NUS Diabetes Centre
    • Clinical Director, Ophthalmic imaging service, Singapore National Eye Centre
    • Clinical Director, SNEC Ocular Reading Centre (SORC)
    • Senior Clinical Lecturer, Yong Loo Lin School of Medicine, National University of Singapore

     

    Research Interests

    Diabetic retinopathy including; epidemiology; genetics; improving screening modalities; novel imaging of the retina; biomarkers, proteonmics and metabolomnics; novel retinal laser treatments and improving treatment modalities and strategies in diabetic retinopathy. Development of stem cell derived-cell replacement therapy for retinal diseases. Paediatric retinal diseases.

    Education

    • 2003
    M.B.B.S. National University of Singapore
    • 2007
    MMED Yong Loo Lin School of Medicine, National University of Singapore
    • 2012
    FRCSEd Royal College of Ophthalmologists (London, UK)
    • 2012
    FAMS Academy of Medicine Singapore

    Previous Positions

    • 2012
    Fellowship, Surgical Vitreo-retina , SNEC
    • 2014
    Fellowship in Vitreo-retinal Diseases, Stanford University
    • 2015
    Fellowship in Vitreo-retinal Diseases, UCLA

    Awards

    • 2013
    ARVO Travel Grant
    • 2014
    Singhealth-MOH HMDP Award: Fellowship in vitreoretinal diseases and novel
    laser retinal treatments (Stanford University) & Fellowship in vitreoretinal diseases: stem cell treatments for retinal diseases (UCLA, Jules Stein Eye Institute)
    • 2017
    Singhealth Clinical Research Excellence Award

    Ophthalmology & Scientific Involvement

    • Member, Singapore Medical Association
    • Member, Association for Research in Vision and Ophthalmology (ARVO)
    • Member, American Society of Retina Surgeons(ASRS)
    • Fellow of the Royal College of Surgeons Edinburgh
    • Council member, Asia Pacific Teleophthalmology Society

     

    Selected publications

    1. Tan GS, Wong CY, Wong TY, Chitra VG, Wong EY, Yeo IY, Aung T. Is Routine Pupil Dilation safe Among Asian Patients with Diabetes. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4110-3.
    2. Tan GS, Wong TY, Fong CW, Aung T. Diabetes, Metabolic Abnormalities and Glaucoma: The Singapore Malay Eye Study. Arch Ophthalmol. 2009 Oct;127(10):1354-61.
    3. Tan GS, He M, Zhao W, Sakata LM, Li J, Nongpiur ME, Raghavan L, Friedman DS, Tin A, Determinants of Lens Vault and Association with Narrow Angles in patients from Singapore. Am J Ophthal. 2012 Jul;154(1):39-46.
    4. Tan GS, Ikram, M.K, Wong, T.Y. Traditional and novel risk factors of diabetic retinopathy and research challenges. Current Medicinal Chemistry. 2013 Sept; 20(26): 3189-3199
    5. Cheng CY, Yamashiro K, Chen LJ, Ahn JY, HuangLL , Huang I, Cheung GC,..,GS Tan, et al. New loci and coding variants confer risk for age-related macular degeneration in East Asians. Nature Communications. 2015 Mar 30;6:6817
    6. Goh JK, Cheung CY, Sim SS, Tan PC, Tan GS, Wong TY. Retinal Imaging Techniques for Diabetic Retinopathy Screening. J Diabetes Sci Technol. 2016 Feb 1;10(2):282-94.
    7. Schwartz SD, Tan G, Hosseini H, Nagiel A. Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(5):ORSFc1-9.
    8. Sabanayagam C, Yip W, Ting DS, Tan G, Wong TY. Ten Emerging Trends in the Epidemiology of Diabetic Retinopathy. Ophthalmic Epidemiol. 2016 Aug;23(4):209-22
    9. Toy BC, Schachar IH, Tan GS, Moshfeghi DM. Chronic Vascular Arrest as a Predictor of Bevacizumab Treatment Failure in Retinopathy of Prematurity. Ophthalmology. 2016 Oct;123(10):2166-75
    10. Ting DS, Tan KA, Phua V, Tan GS, Wong CW, Wong TY. Biomarkers of Diabetic Retinopathy. Curr Diab Rep. 2016 Dec;16(12):125.
    11. Tan GS, Ning Cheung, Rafael Simo, Gemmy C Cheung, Tien Yin Wong, MD, PhD. Diabetic Macular Edema. Lancet Diabetes Endocrinol. 2016 Aug 2.
    12. Ting DSW, Tan GSW. Telemedicine for Diabetic Retinopathy Screening. JAMA Ophthalmol. 2017 May 18.

    A/Prof Louis TONG Hak Tien

    A/Prof Louis TONG Hak Tien

    MBBS(S’pore), FRCS(Ed), DM(Nott), PhD(S’pore)

    Head, Ocular Surface Research Group
    Co-Head, Ocular Inflammation & Immunology Research Group
    Head, Research Training & Development

    Email: louis.tong.h.t@snec.com.sg

    Assoc Prof Louis Tong graduated in 1993 with basic medical degree from the National University of Singapore, registered as a medical practitioner in 1994 and achieved accreditation as an ophthalmologist by the Singapore Medical Council in November 2004. He completed in training in ophthalmology at various centers in the United Kingdom (1996-2000) and in Singapore (2000-2004). He completed a 2 year overseas cornea research fellowship at the Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, as part of A*STAR national science scholarship.

    He holds an associate professor appointment at the Duke-NUS graduate medical school and joint appointment at the Yong Loo Lin School of Medicine, National University of Singapore. He currently holds several appointments at the Singapore Eye Research Institute (SERI): principal clinician-scientist, head of ocular surface research group, head of research training and development, and co-head of ocular inflammation and immunity research group. He Is represented in International expert concensus panels like the international meibomian gland dysfunction workshop and Dry Eye Workshop II, and is member of organizations like the Tear Film and Ocular Surface Society and International Ocular Surface Society. He is a frequent invited speaker at industry events, co-chairs one of the NMRC national scientific grant review panel, and sits on the Singhealth Duke Grant review committee.

    Assoc Prof Tong has been awarded an individual research grant from the National Medical Research Council to study dry eye and proteomics, the NMRC clinician-scientist award for senior investigator, the National Healthcare Innovation to Commercialisation grant (co-awardee), the Wong Hock Boon Society-Singapore Medical Association Outstanding Mentor Award and the SingHealth Publish!Award. He runs a dry eye clinic at the Singapore National Eye Center, as well as a general eye clinic focusing on cataract surgery. His research work includes translation of immunology-based treatments to ocular surface inflammation.

    • Senior Consultant, Corneal and External Eye Disease Service, Singapore National Eye Centre
    • Associate Professor, Duke-NUS Graduate Medical School
    • Adjunct Associate Professor, Department of Ophthalmology Yong Loo Lin School of Medicine, National University of Singapore
    • Clinical senior lecturer, National University of Singapore (part time).
    • Clinical physician faculty member, Singhealth Residency Program

    Research Interests

    Inflammation, dry eye, pterygium

    Education

    • 1993
    MBBS National University of Singapore
    • 1998
    F.R.C.S. Royal College of Surgeons Edinburgh
    • 2002
    Doctor of Medicine University of Nottingham
    • 2004
    FRCS Specialty Fellowship Ophthalmology, Royal College of Surgeons
    • 2009
    PhD National University Singapore

    Previous Positions

    • 2004
    Cornea Research Fellow, Baylor College of Medicine, Houston, TX, USA
    • 1998
    Junior Fellow Diabetic Retinopathy, Queens Medical Center, Nottingham, UK
    • 1997
    Senior House Officer, Sunderland Eye Infirmary, Sunderland, UK
    • 1996
    Senior House Officer, Great Ormond Street Hospital for sick children, London,UK
    • 1995
    Senior House Officer, James Paget Hospital, Great Yarmouth, UK

    Awards

    • 2012
    NMRC clinician scientist award (SI)
    • 2009
    NMRC clinician scientist award (Inv)
    • 2008
    SingHealth Mentorship Program Grant Award
    • 2007
    NUS-Exxon Mobil Award for clinicians
    • 2007
    Singhealth Learning Award
    • 2006
    Association of Vision and Research in Ophthalmology (ARVO) Travel Award
    • 2004
    Association of Vision and Research in Ophthalmology (ARVO) Travel Award

    Ophthalmology & Scientific Involvement

    • Co-Chair of National Medical Research Council Scientific Review Panel (SRP)1 for new investigator grants (NIG)
    • Member, Singhealth Duke-NUS Academic Medicine Education Institute
    • Member, Alcon Advisory Board
    • Consultant, Sanofi-Aventis HTA Council
    • Consultant, Allergan Advisory Board
    • Member, Medical and scientific advisory board, Tear Film and Ocular Surface Society (TFOS)
    • Member, Editorial Board, American Journal of Molecular and Cellular Biology, Columbia International Publishing (CIP)
    • Member, Editorial Board, Ophthalmology and Therapy, Springer Healthcare (Advisory Board member)
    • Member, Editorial Board, Case reports in Ophthalmological Medicine, Hindawi Publishing Corp., NY, USA.
    • Member, Editorial board, World Journal of Ophthalmology, Baishideng Publishing Group, Beijing, China.
    • Member, SERI Strategic Planning Committee
    • Member, Scientific Review, SNEC Research Committee

     

    Selected publications

    1. Tong L, Seow G, Tan J, Thumboo J. Dry eye. BMJ 2012;345:e7533.
    2. Gong L, Sun XH, Ma ZZ, et al, Tong L. A Randomized, Parallel-Group Comparison Study of Diquafosol Ophthalmic Solution in Patients with Dry Eye (Comparison with 0.1% sodium hyaluronate ophthalmic solution) in China and Singapore. Br J Ophthalmol. BJO Online published on January 28, 2015 as 10.1136/bjophthalmol-2014-306084.
    3. Tong L, Thumboo J, Tan YK, Wong TY, Albani S. The eye: A window of opportunity in rheumatoid arthritis? Nature Reviews Rheumato. 2014 Jun 10. doi: 10.1038/nrrheum.2014.85. [Epub ahead of print]
    4. Lam SM, Tong L, Duan XR, Acharya UR, Tan JH, Petznick A, Wenk MR, Shui GH. Longitudinal changes in the levels of tear fluid lysophospholipids and O-acyl-omega-hydroxy fatty acids brought about by eyelidwarming treatment in a cohort of Meibomian Gland Dysfunction patients.J Lipid Res. 2014. P051185.
    5. Lan WW, Chen SL, Tong L. MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease. Cell Cycle. Cell Cycle. 2015 Jun 18;14(12):1973-84. doi: 10.1080/15384101.2014.998077.

    A/Prof Eranga VITHANA

    A/Prof Eranga VITHANA

    PhD

    Director, Laboratory Translational Research
    Head, Ocular Genetics Research Group
    Head, Experimental & Basic Sciences Support Platform

    Email: eranga.nishanthie.vithana@seri.com.sg

    A/Prof Eranga Vithana is a Senior Principal Research Scientist and heads the Ocular Genetics Research group at Singapore Eye Research Institute (SERI). She holds Adjunct appointments with DUKE-NUS Graduate Medical School and National University of Singapore (NUS). She has a PhD in Molecular Genetics from University College London, UK and has been working on ophthalmic genetics for more than 18 years. Her current research is focused on understanding the genetic basis of both rare and common eye diseases with Mendelian and/or complex genetic etiology. She has studied the genetic basis and biochemical mechanisms of corneal dystrophies, inherited photoreceptor degenerations (IPDs), all forms of glaucoma (POAG, PACG, NTG, congenital glaucoma), as well as quantitative traits of ocular diseases. A/Prof Vithana’s research has led to the discovery of genes causative of retinitis pigmentosa, corneal endothelial dystrophies, glaucoma and ocular quantitative traits. A/Prof Vithana has published more than 60 peer-reviewed papers, in the best journals for human genetics including Nature Genetics, American Journal of Human Genetics, PLOS genetics and Human Molecular Genetics. She has presented her scientific findings in more than 50 conference proceedings and has been an invited speaker at numerous Ophthalmic and Genetic conferences.

    Other concurrent positions

    • Adjunct Associate Professor, Dept of Ophthalmology, NUS
    • Adjunct Associate Professor, Dept of Neuroscience, Duke NUS

     

    Research Interests

    Current research is focused on understanding the genetic basis of both rare and common eye diseases with Mendelian and/or complex genetic etiology. Studies conducted on the genetic basis and biochemical mechanisms of corneal dystrophies, inherited photoreceptor degenerations (IPDs), all forms of glaucoma (POAG, PACG, NTG, congenital glaucoma), as well as quantitative traits of ocular diseases.

     

    Education

    • 1998 PhD University College London, University of London
    • 1994 BSc Hons Queen Mary and Westfield College, University of London

     

    Previous Positions

    • 2004 Senior Research Fellow, Institute of Ophthalmology, University College, London

     

    Awards

    • 2006 Best Oral Paper (Scientist) Award in the 15th SGH Annual Scientific Meeting, Singapore
    • 2006 SingHealth Outstanding Publication Award, Singapore

     

    Ophthalmology & Scientific Involvement

    • 2005 – Current Bi-Annual meeting of the ASIA- Association for Research in Vision and Ophthalmology (ASIA-ARVO), Genetic Symposium organizer
    • 2011 Deputy Chairman of ASIA ARVO working committee, Singapore

     

    Selected publications (out of 62):

    1. Ogando DG, Jalimarada SS, Zhang W, Vithana EN, Bonanno JA. SLC4A11 is an EIPA-sensitive Na+-Dependent pHi Regulator. Am J Physiol Cell Physiol. 2013 Jul 17. (IF=3.71)
    2. Vilas GL, Morgan PE, Loganathan S, Liu J, Riau AK, Young JD, Metha J, Vithana EN, Casey JR. Transmembrane water flux through SLC4A11: a route defective in corneal disease. Hum Mol Genet. 2013 Jun 27. (IF=8.05)
    3. Barathi VA, Kwan JL, Tan QSW, Weon SR, Seet LF, Goh LK, Vithana EN, Beuerman RW. Muscarinic Cholinergic Receptor (M2) Plays A Critical Role In The Development Of Myopia. Disease Models & Mechanisms 2013 (IF =4.94)
    4. Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A, Hewitt AW, Koehn D, Hysi PG, Ramdas WD, Zeller T, Vithana EN, Cornes BK, Tay WT, Tai ES, Cheng CY, Liu J, Foo JN, Saw SM, Thorleifsson G, Stefansson K, Dimasi DP, Mills RA, Mountain J, Ang W, Hoehn R, Verhoeven VJ, Grus F, Wolfs R, Castagne R, Lackner KJ, Springelkamp H, Yang J, Jonasson F, Leung DY, Chen LJ, Tham CC, Rudan I, Vatavuk Z, Hayward C, Gibson J, Cree AJ, Macleod A, Ennis S, Polasek O, Campbell H, Wilson JF, Viswanathan AC, Fleck B, Li X, Siscovick D, Taylor KD, Rotter JI, Yazar S, Ulmer M, Li J, Yaspan BL, Ozel AB, Richards JE, Moroi SE, Haines JL, Kang JH, Pasquale LR, Allingham RR, Ashley-Koch A; NEIGHBOR Consortium, Mitchell P, Wang JJ, Wright AF, Pennell C, Spector TD, Young TL, Klaver CC, Martin NG, Montgomery GW, Anderson MG, Aung T, Willoughby CE, Wiggs JL, Pang CP, Thorsteinsdottir U, Lotery AJ, Hammond CJ, van Duijn CM, Hauser MA, Rabinowitz YS, Pfeiffer N, Mackey DA, Craig JE, Macgregor S, Wong TY. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet. 2013 Feb; 45(2):155-63. (IF=36.37)
    5. Vithana EN*, Khor CC*, Qiao C*, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu L, Jia H, Ho CL, Sim KS, Wu RY, Tham CC, Chew PT, Su DH, Oen FT, Sarangapani S, Soumittra N, Osman EA, Wong HT, Tang G, Fan S, Meng H, Huong DT, Wang H, Feng B, Baskaran M, Shantha B, Ramprasad VL, Kumaramanickavel G, Iyengar SK, How AC, Lee KY, Sivakumaran TA, Yong VH, Ting SM, Li Y, Wang YX, Tay WT, Sim X, Lavanya R, Cornes BK, Zheng YF, Wong TT, Loon SC, Yong VK, Waseem N, Yaakub A, Chia KS, Allingham RR, Hauser MA, Lam DS, Hibberd ML, Bhattacharya SS, Zhang M, Teo YY, Tan DT, Jonas JB, Tai ES, Saw SM, Hon DN, Al-Obeidan SA, Liu J, Chau TN, Simmons CP, Bei JX, Zeng YX, Foster PJ, Vijaya L, Wong TY, Pang CP, Wang N, Aung T. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. (*Joint first authors). Nat Genet. 2012 Oct; 44(10):1142-6. (IF=36.37)
    6. Liu J, Seet L-F, Koh LW, Venkatraman A, Venkataraman D, Mohan R, Praetorius J, Bonanno JA, Aung T, Vithana EN. Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line. Invest Ophthalmol Vis Sci. 2012 Jun 5;53(7):3270-9. (IF-3.582)
    7. Vilas GL, Loganathan SK, Quon A, Sundaresan P, Vithana EN, Casey J. Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations. Hum Mutat. 2012; 33(2):419-28. (IF=5.956)
    8. Cornes BK, Khor CC, Nongpiur ME, Xu L, Tay W-T, Zheng Y, Lavanya R, Li Y, Wu R, Sim X, Wang Y-X, Chen P, Teo YY, Chia K-S, Seielstad M, Liu JJ, Hibberd ML, Cheng C-Y, Saw SM, Tai E-S, Jonas JB, Vithana EN#, Wong TY#, Aung T#. Identification of Four Novel Variants That Influence Central Corneal Thickness in Multi-Ethnic Asian Populations. (# Joint last authors) Hum Mol Genet 2012; 21(2):437-45. (IF=8.05)
    9. Khor CC*, Ramdas WD*, Vithana EN*, Cornes BK, Sim X, Tay W-T, Saw S-M, Zheng Y, Lavanya R, Wu R, Wang JJ, Mitchell P, Uitterlinden AG, Rivadeneira F, Teo YY, Chia KS, Seielstad M, Hibberd M, Vingerling JR, Klaver CCW, Jansonius NM, Tai E-S, Wong TY, van Duijn CM, Aung T. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (*Joint first authors) Hum Mol Genet. 2011; 20(9):1864-72. (IF=8.05)
    10. Vithana EN*, Aung T*, Khor CC*, Cornes BK, Tay W-T, Sim X, Lavanya R, Wu R, Zheng Y, Chia KS, Seielstad M, Saw SM, Tai ES, Wong TY. Collagen related genes influence the glaucoma risk factor, central corneal thickness. (*Joint first authors). Hum Mol Genet. 2011; 20(4):649-58. (IF=8.05)
    11. Riazuddin SA*, Vithana EN*, Seet LF, Liu Y, Al-Saif A, Koh LW, Heng YM, Aung T, Meadows DN, Eghrari AO, Gottsch JD, Katsanis N. Missense mutations in the sodium borate co-transporter SLC4A11 cause late onset Fuchs corneal dystrophy. (joint first authors) Hum Mutat. 2010; 31(11):1261-8. (IF=6.89)
    12. Amerasinghe N, Zhang J, Thalamuthu A, He M, Vithana EN, Viswanathan A, Wong TY, Foster PJ, Aung T. The Heritability and Sibling Risk of Narrow Angles. Ophthalmology. 2011 Mar; 118(3):480-5. (IF=5.49)
    13. Laude A, Cackett PD, Vithana EN, Yeo IY, Wong D, Koh AH, Wong TY, Aung T. Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease? Prog Retin Eye Res. 2010; 29(1):19-29. (IF-6.31)- One of the 5 ‘top picks’ for the best publication of 2010 by the Vision Research Community
    14. Vithana EN, Morgan PE, Ramprasad V, Tan DT, Yong VH, Venkataraman D, Venkatraman A, Yam GH, Nagasamy S, Law RW, Rajagopal R, Pang CP, Kumaramanickevel G, Casey JR, Aung T. SLC4A11 mutations in Fuchs endothelial corneal dystrophy. Hum Mol Genet. 2008;17(5):656-66. (IF-7.81 in 2008)
    15. Ramprasad VL, Ebenezer ND, Aung T, Rajagopal R, Yong VHK, Tuft SJ, Viswanathan D, El-Ashry MF, Liskova P, Tan DTH, Bhattacharya SS, Kumaramanickavel G & Vithana EN. Novel SLC4A11 Mutations in Patients with Recessive Congenital Hereditary Endothelial Dystrophy (CHED2). Hum Mutat. 2007; 28(5):522-3. (IF-7.92 in 2007)
    16. Vithana EN, Morgan P*, Sundaresan P*, Ebenezer N, Tan DTH, Mohamed MD, Anand S, Khine KO, Venkataraman D, Yong VHK, Salto-Tellez M, Venkatraman A, Guo K, Hemadevi B, Srinivasan M, Prajna V, Khine M, Casey JR, Inglehearn CF & Aung T. Mutations in Sodium-borate co-transporter SLC4A11 cause recessive Congenital Hereditary Endothelial Dystrophy, CHED2. Nat. Genet. 2006 38(7):755-7. (IF-25.79 in 2006) (*Joint first authors)
    17. Deery, E., Vithana, EN., Newbold, R., Gallon V.A., Bhattacharya, S.S., Warren, M.J., Hunt, D.M., Wilkie, S.E. (2002). Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31. Hum Mol Genet. 2002; 11(25): 3209-3219. (IF-7.81)
    18. Vithana EN, Abu-Safieh L, Allen MJ, Carey A, Papaioannou M, Chakarova C, Al-Maghtheh M, Ebenezer ND, Willis C, Moore AT, Bird AC, Hunt DM, Bhattacharya SS. A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11). Mol Cell. 2001 8(2): 375-81. (IF- 14.97)
    19. Vithana, E.N., Al-Maghtheh, M., Inglehearn, C.F., Moore, T., Bird, A.C and Bhattacharya, S.S (1998). Segregation of a PRKCG mutation in two RP11 families. Am. J. Hum. Genet. 62, 1248-1252. (IF-12.65)

    A/Prof Tina WONG Tzee Ling

    A/Prof Tina WONG Tzee Ling

    BSc(Hons), MBBS, FRCOphth, FRCS(Ed), FAMS, PhD(Lond)

    Head, Ocular Therapeutics & Drug Delivery Research Group

    Email: tina.wong.t.l@snec.com.sg

    Associate Prof Tina Wong is a Senior Consultant in the Glaucoma Service at the Singapore National Eye Centre (SNEC) as well as head of the Ocular Drug Delivery Group at the Singapore Eye Research Institute (SERI). She holds an adjunct faculty appointment at the School of Materials Science and Engineering at Nanyang Technological University (NTU). She is also co-Director of the Ocular Therapeutic Engineering Centre (OTEC) at NTU.

     

    Prior to taking up her position in Singapore, she was a Glaucoma Fellow and Research Fellow at Moorfields Eye Hospital in London, UK, where she had completed her general Ophthalmic training. She was awarded the Wellcome Trust Vision Research Fellowship in 1999 for which completed a PhD on the role of matrix metalloproteinases in conjunctival wound healing following glaucoma surgery in Professor Sir Peng Khaw’s laboratory at the Institute of Ophthalmology, University College London. Her research led to the award of the Oxford Ophthalmological Congress Fould’s Trophy as well as the prestigious Moorfields Research Gold Medal in 2006.

     

    Her research focuses on the discovery of new methods to improve ocular wound healing following surgery. The second arm of her research involves the development of sustained ocular drug delivery systems and the delivery of targeted cell based therapies. This is achieved through a combination of the knowledge garnered from the basic understanding of wound healing biology, application of appropriate animal models of ocular disease and the innovative application of materials science technology and nanoengineering to develop advanced, cutting-edge solutions to improve on current diagnostic tools, medical and surgical treatments in glaucoma and other ophthalmic diseases that require long-term and or intensive topical medications to manage the disease. These include anterior segment ocular inflammation, allergy and infection, and proliferative retinal diseases.

     

    Associate Prof Wong’s laboratory has recently developed and published a new mouse model of ocular scarring which will greatly facilitate the study and discovery of potential new antifibrotic therapeutic targets.

     

    Together with her team at NTU, a first-ever sustained drug release nanomedicine for glaucoma has been developed and a Phase 1 trial successfully completed in SERI, under the Translational Clinical Research (TCR) 5 year grant of S$25Million that was awarded by the Singapore National Medical Research Council to SERI in 2008.

     

    A/Prof Wong has authored over 60 peer-reviewed publications, 4 book chapters and a book – a patient handbook on glaucoma. She currently holds 8 patents to her name.

     

    She is involved in both local and international education programmes, courses and regularly presents at international meetings. She is a member of the Associate Advisory Board of the World Glaucoma Association. Assoc Professor Wong was awarded the National Clinician Scientist Award in 2010 for her work on novel drug delivery for glaucoma, and the recipient of the Distinguished Service Award at the APAO in Sydney in 2011 for her extensive contributions to ophthalmology and research in glaucoma.

     

    Ophthalmology & Scientific Involvement

    Local

    • National Medical Research Council, Local Review Panel member
    • SingHealth Research Foundation, Scientific Grant Review Committee, member (Translational)
    • MOH, Clinician-scientist Residents, SAB Scholarship Administration Panel Member
    • Committee Member, Product Vigilance Advisory Committee of the Health Sciences Authority, Singapore
    •  Chairperson for fundraising in SERI

     

    International

    • Associate Advisory Board Member of the World Glaucoma Association
    • Examiner for Royal College of Surgeons of Edinburgh, (Ophthalmology) UK,

     

    Selected publications:

    1. Effect of chronic anti-glaucoma medications and trabeculectomy on tear osmolarity. Lee SY, Wong TT, Chua J, Boo C, Soh YF, Tong L. Eye 12 July 2013
    2. A new design and application of bioelasters for better control of intraocular pressure in a glaucoma drainage device. Luong QM, Lei Shang, Ang M, Wong TT, Venkatraman SS. Adv Healthcare Materials May 2013 Accepted
    3. A biodegradeable sustained release Prednisolone acetate loaded microfilm drug delivery system effectively prolongs corneal allograft survival in the rat keratoplasty model. Liu YC, Peng Y, Lwing NC, Venkatraman SS, Wong TT, Mehta JS. PLoS One May 2013 Accepted
    4. Novel insight into the inflammatory and cellular responses following experimental glaucoma surgery: a roadmap for inhibiting fibrosis. Seet LF, Finger SN, Chu SWL, Toh LZ, Wong TT. Current Mol Med 2013
    5. R Foo, E Lamoureux, R Wong, SW Ho, P Chiang, G Rees, T Aung, TT Wong. Acceptance, attitudes and beliefs of Singaporean Chinese towards an ocular implant for glaucoma dryg delivery. Invet Ophthalmol Vis Sci. Nov 2012
    6. Nanomedicine for glaucoma: Liposomes provide sustained release of latanoprost in the eye. JV Natarajan, M Ang, A Darwitan, TT Wong, SS Venkratraman. Int J of Nanomed. E Pub Jan 4 2012
    7. A Narayanaswamy, K Lee, M Zhen, J Chua, SM Chai, PY Boey, C Zheng, T Aung, S Venkatraman, TT Wong. Randomised, controlled trial of a sustained delivery formulation of 5-fluorouracil for the treatment of failing blebs. Ophthalmology, 2011, Feb;119(2):314-20. Epub 2011 Dec 6
    8. Seet LF, R Su, LZ Toh, TT Wong. In vitro analysis of the anti-fibrotic effect of SPARC silencing in human Tenon’s fibroblasts: comparisons with mitomycin-C. J Cell Mol Med 2011 Jul E Pub.
    9. Seet LF, R Su, VA Barathi, WS Lee, R Poh, YM Heng, E Manser, EN Vithana, T Aung, MS Weaver, EH Sage, TT Wong. SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery. PLos One 2010 Feb, 25(5):e9415.

    Prof WONG Tien Yin

    Prof WONG Tien Yin

    MBBS, MMed (Ophth), FRCSE, FRANZCO, MPH, PHD (Johns Hopkins)

    Senior Principal Clinician Scientist

    Email: wong.tien.yin@singhealth.com.sg

    Prof Wong is a clinician-scientist, who directs a clinical research program in the following areas:

    1. Retinal and ocular imaging techniques to predict diseases.
    2. Epidemiology of age-related eye diseases in Asians
    3. Genetic basis of age-related macular degeneration and its clinical presentation
    4. Mechanisms in diabetic retinopathy and implications in novel treatment

    He has published more than 600 papers, including papers in the New England Journal of Medicine and the Lancet. For his work, Prof Wong has been recognized internationally and nationally with numerous awards, including the Singapore Translational Researcher Award (STaR), the National Outstanding Clinician-Scientist Award and the President’s Science Award.

    Research Interests

    Diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, retinal diseases, ocular imaging, and epidemiology of eye diseases

    Other concurrent positions

    • Medical Director, Singapore National Eye Center
    • Group Director, Research, SingHealth
    • Vice Dean, Office of Clinical Research, Duke-NUS Medical School
    • Professor, Dept of Ophthalmology, National University of Singapore

    Education

    • 1992
    M.B.B.S. National University of Singapore, Singapore
    • 1997
    M.P.H. Johns Hopkins University, Baltimore, USA
    • 1999
    F.R.C.S.E. Royal College of Surgeons of Edinburgh, UK
    • 1999
    M.MED National University of Singapore, Singapore
    • 2002
    Ph.D. Johns Hopkins University, Baltimore, USA
    • 2004
    FRANZCO Royal Australian & New Zealand College of Ophthalmologists
    • 2004
    FAFPHM Australian Faculty of Public Health Medicine Royal Australian College of Physicians
    • 2010
    FAMS Academy of Medicine, Singapore

    Previous Positions

    • 2008
    Managing Director, Centre for Eye Research Australia
    • 2008
    Head of University of Melbourne Department of Ophthalmology
    • 2006
    Professor, Department of Ophthalmology, University of Melbourne
    • 2004
    Associate Professor, Department of Ophthalmology, University of Melbourne
    • 1999
    Assistant Professor, Department of Ophthalmology, National University of Singapore

    Awards

    • 2013
    ARVO Fellow (Silver Award), USA
    • 2011
    Johns Hopkins University Knowledge of the World Award, USA
    • 2010
    President’s Science Award, Singapore
    • 2009
    Outstanding Researcher of the Year, National University of Singapore, Singapore
    • 2007
    The Australian Society for Medical Research AMGEN Medical Researcher Award, Australia
    • 2006
    The Alcon Research Institute Award, USA
    • 2006
    The Commonwealth Minister of Health Award for Excellence in Medical Research, Australia
    • 2005
    The Woodward Medal for Science and Technology, University of Melbourne, Australia

    Ophthalmology & Scientific Involvement

    • Member, Allergan Advisory Board
    • Executive Committee Member, Australian & New Zealand Society of Retinal Specialists
    • Member, Novartis Advisory Board
    • Member, Pfizer Advisory Board
    • Member, NHMRC Grants Review Panel
    • Member, Editorial Board, Diabetes Care
    • Member, Editorial Board, Ophthalmic Epidemiology
    • Member, Editorial Board, Investigative Ophthalmology and Visual Science
    • Executive Editor, American Journal of Ophthalmology
    • Member, Singapore Society of Ophthalmology, Singapore
    • Member, Delta Omega (Alpha Chapter) Society, USA
    • Member, Association for Research and Vision in Ophthalmology, USA
    • Member, International Society for Geographic & Epidemiological Ophthalmology, USA
    • Member, American College of Epidemiology, USA
    • Member, American Academy of Ophthalmology, USA
    • Member, Oceania Retinal Association, Australia
    • Member, Macula Society, USA

    Selected Publications

    1. Wong TY, Klein R, Couper DJ, et al. Retinal microvascular abnormalities and incident clinical strokes. The Atherosclerosis Risk in the Communities Study. Lancet 2001: 358: 1134-40 (IF:28.6)
    2. Wong TY, Klein R, Sharrett AR, et al. Retinal arteriolar narrowing and risk of diabetes in middle-aged persons. JAMA 2002; 287: 2528-33. (IF:25.5)
    3. Wong TY, Klein R, Sharrett AR, et al. Retinal arteriolar narrowing and incident coronary heart disease in men and women: JAMA 2002; 287:1153-9. (IF:25.5)
    4. Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med 2004;351:2310-7 (IF:52.6)
    5. Wong TY, Rosamond WR, Chang P, et al. Retinopathy and risk of congestive heart failure. JAMA 2005: 293:63-69. (IF:25.5)
    6. Mohamed Q, Gillies, MC, Wong TY. Management of diabetic retinopathy: a systematic review. JAMA 2007;298:902-916. (IF:25.5)
    7. Wong TY, Liew G, Mitchell P. Clinical update: New treatments for age-related macular degeneration. Lancet 2007; 370:204-206. (IF:28.6)
    8. Wong TY, Liew G, Tapp R, et al. Relation of fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies. Lancet 2008; 371: 736-743. (IF:28.6)
    9. Wong TY, Scott IU. Retinal vein occlusion. New England Journal of Medicine 2010 Nov 25; 363(22): 2135-44 (IF:52.6)
    10. Lim L, Mitchell P, Seddon J, Holz F, Wong TY. Age-related Macular Degeneration. The Lancet 2012. 379(9827): p. 1728-1738. (IF:28.6)

    Dr Gary YAM

    Dr Gary YAM

    Head, Experimental Microscopy Support Platform
    Principal Investigator

    Email: gary.yam.h.f@seri.com.sg

    Dr Gary Yam obtained his PhD degree from The Chinese University of Hong Kong and had his postdoctoral training in Department of Pathology, University of Zurich. His research interests include ocular cell biology and stem cell study, gene function, histopathology and experimental animal modeling of eye diseases. He has contributed more than 70 scientific articles in peer reviewed journals and has been a recipient of different awards including the Alfred Vogt Prize (2007) of the Swiss Ophthalmology Society, the most prestigious award in Switzerland for the scientific research in ophthalmology, and Young Scientist Awards by the Society for Histochemistry (2003 and 2005) and the American Society for Biochemistry and Molecular Biology (2003). He serves as reviewers for more than 10 international journals and research grants. Currently, his research is focused on corneal tissue engineering and chaperone-assisted therapy of protein aggregation diseases.

    Research Interests

    • Ocular surface cell biology
    • Corneal tissue engineering
    • Stem cell epigenetics, reprogramming and therapy
    • Protein folding disease, protein quality control and chaperone-assisted protein correction

    Education

  • 1988
  • B.Sc. (Hons) Chinese University of Hong Kong, Hong Kong
  • 1990
  • M.Phil. Chinese University of Hong Kong, Hong Kong
  • 1998
  • Ph.D. Chinese University of Hong Kong, Hong Kong

    Previous Positions

  • 2006
  • Assistant Professor, Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong
  • 2004
  • Research Assistant Professor, Division of Cell & Molecular Pathology, Department of Pathology, University of Zurich, Switzerland
  • 2002
  • Research Scientist, Division of Cell & Molecular Pathology, Department of Pathology, University of Zurich, Switzerland
  • 1999
  • Post-Doctoral Research Fellow, Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong
  • 1993
  • Technician, Department of Anatomy, Chinese University of Hong Kong

    Awards

  • 2009
  • Action for Vision Foundation, Best Research Award (1st runner-up)
  • 2007
  • Swiss Ophthalmology Society, Alfred Vogt Prize
  • 2007
  • Action for Vision Foundation, Best Research Award (2nd runner-up)
  • 2003 & 2005
  • Society for Histochemistry, Young Scientist Award

    Selected publications

    1. Huang L, Liang JJ, Geng YQ, Tsang WM, Yao X, Jhanji V,Zhang MZ, Cheng HS, Pang CP, Yam GHF. Directing adult human periodontal ligament-derived stem cells to retinal fate. Invest Ophthalmol Vis Sci. 2013. Jun 6:54(6):3965-74
    2. Zhang T, Yam GHF, Riau AK, Poh R, Allen JC, Peh GS, Beuerman RW, Tan DT, Mehta JS. The effect of amniotic membrane de-epithelialization method on its biological properties and ability to promote limbal epithelial cell culture. Invest Ophthalmol Vis Sci. 2013 Apr 30;54(4):3072-81.
    3. Ren RJ, Liu WW, Huang L, Liu DT, Choy KW, Shi JT, Zhao JY, Zhao B, Guan M, Shields CL, Pang CP, Li B, Yam GHF. Role of BMI-1 in oncogenic behavior of retinoblastomas. Mol Vis. 2013. 19:561-574.
    4. Yam GHF, Wang KJ, Jhanji V, Choy KW, Baum L, Pang CP. In vitro amyloid aggregate forming ability of TGFBI mutants that cause corneal dystrophies. Invest Ophthalmol Vis Sci. 2012 Sep;53(9):5890-8.
    5. Lee SK, Teng YF, Wong HK, Ng TK, Huang L, Lei P, Zhang MZ, Liu YP, Choy KW, Lam DSC, Yam GHF, Pang CP. MicroRNA-145 Regulates Human Corneal Epithelial Differentiation. PLoS One. 2011 Jun; 6(6):e21249.
    6. Zhang XM, Liu DTL, Chiang WY, Choy KW, Pang CP, Lam DSC, Yam GHF. Novel immunopanning purification and long-term culture of human retinal ganglion cells. Mol Vis. 2010 Dec 28;16:2867-72.
    7. Bai HQ, Teng YF, Wong L, Jhanji V, Pang CP, Yam GHF. Proliferative and migratory aptitude in pterygium. Histochem Cell Biol. 2010 Oct 12;134:527-35.
    8. Huang Y, Lam. DSC, Wang N, Yam GHF. A natural osmolyte corrects the phenotype of a MYOC mutation causing primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3743-9.
    9. Jia LY, Sun L, Fan DSF, Lam DSC, Pang CP, Yam GHF. Topical Ginkgo biloba extract alleviated steroid-associated ocular hypertension. Arch Ophthalmol. 2008 Dec;126 (12):1700-6.
    10. Mehta JS, Vithana EN, Tan DT, Yong VH, Yam GHF, Law RW, Chong WG, Pang CP, Aung T. Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):184-8.
    11. Roth J, Yam GHF, Fan JY, Hirano K, Gaplovska-Kysela K, Le Fourn Valerie, Guhl B, Santimaria R, Torossi T, Ziak M, Zuber Ch. Protein quality control: the who’s who, the where’s and therapeutic escapes. Histochem Cell Biol. 2008 Feb;129(2):163-77.
    12. Vithana EN, Morgan PE, Ramprasad V, Tan DT, Yong VH, Venkataraman D, Venkatraman A, Yam GHF, Nagasamy S, Law RW, Rajagopal R, Pang CP, Kumaramanickevel G, Casey JR, Aung T. SLC4A11 mutations in Fuchs endothelial corneal dystrophy. Hum Mol Genet. 2008 Mar;17(5):656-66.
    13. Yam GHF, Gaplovska-Kysela K, Zuber Ch, Roth J. Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin and rescues cells from endoplasmic reticulum stress and apoptosis. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1683-90.
    14. Yam GHF, Gaplovska-Kysela K, Zuber Ch, Roth J. Aggregated myocilin induces Russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma. Am J Pathol. 2007 Jan;170(1):100-9.
    15. Yam GHF, Bosshard N, Zuber Ch, Steinmann B, Roth J. A pharmacological chaperone corrects the lysosomal storage in Fabry disease caused by trafficking-incompetent variants. Am J Physiol Cell Physiol. 2006 Apr;290(4):C1076-82.
    16. Yam GHF, Zuber C, Roth J. A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder. FASEB J. 2005 Jan;19(1):12-8.

    A/Prof Yasuo YANAGI

    A/Prof Yasuo YANAGI

    M.D, Ph.D

    Clinician Scientist

    Email: yasuo.yanagi@snec.com.sg

    A/Prof Yanagi is a Clinician Scientist and is engaged in clinical research and basic science research including the SERI-IMCB Programme in Retinal Angiogenic Diseases. Specializing in retinal disorders, his scientific accomplishments include discovery of molecular targets and the development of a novel drug delivery system to treat retinal and choroidal disorders, including age-related macular degeneration. In addition to directing laboratory research, he has led several important clinical research projects.
    A/Prof Yanagi is a well-published clinician scientist with more than 100 peer reviewed articles. He has received numerous prestigious awards on national and regional levels including the Asia Pacific Academy of Ophthalmology – Nakajima Award in 2011 and the Japanese Ophthalmological Society Councilors Nominated Award in 2014.

    Other concurrent positions

    • Consultant, Medical Retinal Department, Singapore National Eye Centre
    • Adjunct Professor, Jichi Medical School, Japan

    Research Interests

    Basic and clinical research of ocular diseases including retinal diseases such as age-related macular degeneration, retinal vascular disease.

    Education

  • 1995
  • The University of Tokyo, Japan, Bachelor of Medicine
  • 2001
  • The University of Tokyo, Japan, Doctor of Philosophy

    Previous Positions

  • 2015-2012
  • Assistant Professor, Department of Ophthalmology, Faculty of Medicine, The University of Tokyo, Japan
  • 2012-2004
  • Assistant Professor, Ophthalmology and Visual Correction, The University of Tokyo Hospital, Japan
  • 2004-2003
  • Research fellowship for Young Scientists, Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan
  • 2003-2001
  • Postdoctoral fellow, Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Japan
  • 2001-1997
  • Graduate Student, Graduate School of Medicine, The University of Tokyo, Japan
  • 1997-1996
  • Residency in Ophthalmology, Tokyo Kosei Nenkin Hospital, Japan
  • 1996-1995
  • Residency in Ophthalmology, The Tokyo University Hospital, Japan

    Awards

  • 2014
  • Japan Medical Association Medical Research Encouraging Prize
  • 2014
  • Japanese Ophthalmological Society Councilors Nominated Award
  • 2011
  • Japanese Retina and Vitreous Society Tano Young Investigator Award
  • 2011
  • Asia Pacific Academy of Ophthalmology Nakajima Award
  • 2011
  • Rohto Pharmaceutical Co. Ltd Award
  • 2011
  • Alcon Japan Hida Memorial Award
  • 2008
  • Japan Ophthalmological Society Young Investigator Award

    Ophthalmology & Scientific Involvement

    • Member, Macular Society, USA
    • Member, The Association for Research in Vision and Ophthalmology (ARVO), USA
    • Member, American Academy of Ophthalmology, USA
    • Trustee, The Isshinkai Foundation, Japan

    Selected publications

    1. Aoki A, Tan X, Yamagishi R, Shinkai S, Obata R, Miyaji T, Yamaguchi T, Numaga J, Ito H, Yanagi Y. Risk Factors for Age-Related Macular Degeneration in an Elderly Japanese Population: The Hatoyama Study. Invest Ophthalmol Vis Sci. 2015; 56(4): 2580-5. [IF 3.441]
    2. Obata R, Yanagi Y. Quantitative Analysis of Cone Photoreceptor Distribution and Its Relationship with Axial Length, Age, and Early Age-Related Macular Degeneration. PLoS One. 2014; 9(3): e91873. [IF 3.534]
    3. Arita R, Yanagi Y, Honda N, Maeda S, Maeda K, Kuchiba A, Yamaguchi T, Yanagihara Y, Suzuki H, Amano S. Caffeine Increases Tear Volume Depending on Polymorphisms within the Adenosine A2a Receptor Gene and Cytochrome P450 1a2. Ophthalmology. 2012; 119(5): 972-8. [IF 5.563]
    4. Fujimura S, Takahashi H, Yuda K, Ueta T, Iriyama A, Inoue T, Kaburaki T, Tamaki Y, Matsushima K, Yanagi Y. Angiostatic Effect of Cxcr3 Expressed on Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2012; 53(4): 1999-2006. [IF 3.441]
    5. Ueta T, Inoue T, Furukawa T, Tamaki Y, Nakagawa Y, Imai H, Yanagi Y. Glutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells. J Biol Chem. 2012; 287(10): 7675-82. [JIF 4.651]
    6. Yuda K, Takahashi H, Inoue T, Ueta T, Iriyama A, Kadonosono K, Tamaki Y, Aburatani H, Nagai R, Yanagi Y. Adrenomedullin Inhibits Choroidal Neovascularization Via Ccl2 in the Retinal Pigment Epithelium. Am J Pathol. 2012; 181(4): 1464-72. [IF 4.522]
    7. Ueta T, Inoue T, Yuda K, Furukawa T, Yanagi Y, Tamaki Y. Intense Physiological Light Upregulates Vascular Endothelial Growth Factor and Enhances Choroidal Neovascularization Via Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1alpha in Mice. Arterioscler Thromb Vasc Biol. 2012; 32(6): 1366-71. [IF 6.338]
    8. Iriyama A, Oba M, Ishii T, Nishiyama N, Kataoka K, Tamaki Y, Yanagi Y. Gene Transfer Using Micellar Nanovectors Inhibits Choroidal Neovascularization in Vivo. PLoS One. 2011; 6(12): e28560. [IF: 4.092]
    9. Nomura Y, Ueta T, Iriyama A, Inoue Y, Obata R, Tamaki Y, Yamaguchi T, Yanagi Y. Vitreomacular Interface in Typical Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Ophthalmology. 2011; 118(5): 853-9. [IF 5.454]
    10. Ueta T, Mori H, Kunimatsu A, Yamaguchi T, Tamaki Y, Yanagi Y. Stroke and Anti-Vegf Therapy. Ophthalmology. 2011; 118(10): 2093- e2. [IF 5.454]

    Dr ZHOU Lei

    Dr ZHOU Lei

    Ph.D.

    Head, Proteomics Support Platform

    Email: zhou.lei@seri.com.sg

    Dr. Zhou Lei is a Senior Principal Research Scientist and heads the Ocular Proteomics Platform in Singapore Eye Research Institute. He was trained as a bio-analytical chemist. He applies cutting-edge mass spectrometry and proteomics/metabolomics technologies for eye research. He joined Singapore Eye Research Institute after completed his Ph.D. in Department of Chemistry, National University of Singapore in 1998.

    Other concurrent positions

    • Adjunct Assistant Professor, Dept. of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
    • Adjunct Assistant Professor, SRP in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School

     

    Research Interests

    Biological mass spectrometry, proteomics, metabolomics, multi-dimensional liquid chromatograph-tandem mass spectrometry (MDLC-MS/MS), quantitative proteomics including iTRAQ, high resolution MRM, and MS/MSALL with SWATHacquisition, characterization of post-translational modifications (PTMs).

    Areas of particular interests include: (a) discover new biomarkers for ocular diseases, e.g. tear fluid biomarkers for dry eye, lacrimal gland tumor, thyroid eye disease; understand the pathogenesis of ocular diseases, e.g. myopia, dry eye, pterygium, diabetic retinopathy, etc; (b) Ocular metabolomics using LC-MS/MS, e.g. serum metabolomics in age-related macular degeneration and diabetic retinopathy; (c) Antimicrobial peptides: developing new peptide antibiotics for ocular infections, defensin-based cationic antimicrobial peptide design, synthesis, characterization and purification; (d) Ocular drug pharmacokinetics: quantify drug levels in ocular fluids and tissues using liquid chromatography mass spectrometry (LC/MS).

    Education

    • 1985
    B.Sc. Shanghai Normal University, Shanghai
    • 1988
    M.Sc. Shanghai Normal University, Shanghai
    • 1998
    Ph.D. National University of Singapore, Singapore

    Previous Positions

    • 2012
    Senior Principal Research Scientist, Singapore Eye Research Institute
    • 2007
    Principal Research Scientist, Singapore Eye Research Institute
    • 2004
    Senior Research Fellow, Singapore Eye Research Institute
    • 1998
    Research Fellow, Singapore Eye Research Institute
    • 1992
    Research Chemist and Group Leader. Quality Control Department, Sino-American Shanghai RAAS Blood Products Co., Ltd., Shanghai.
    • 1988
    Research associate, University Interdisciplinary Research Center, Shanghai Normal University, Shanghai.

    Awards

    • 2009
    Best Poster (Merit prize, Basic Science), 8th NHG Annual Scientific Congress

    Ophthalmology & Scientific Involvement

    • Board Member, Singapore Society for Mass Spectrometry
    • Associate Editor, Journal of Integrated OMICS
    • Editorial Board Member, Journal of Proteomics & Computational Biology
    • Editorial Board Member, ISRN Chromatography
    • Editorial Board Member, Asia Pacific BioTech News
    • Editorial Board Member, Chinese Journal of Experimental Ophthalmology

     

    Patents

    • WO/2007/126391, INVESTIGATION OF MUCOSA DRYNESS CONDITIONS
    • WO/2007/126392, ANTIMICROBIAL PEPTIDES
    • WO/2009/131548, MULTIMERIC FORMS OF ANTIMICROBIAL PEPTIDES
    • WO/2013/036207, DERIVATIVES OF XANTHONE COMPOUNDS
    • WO2014106833 A1, A PROCESS FOR IDENTIFICATION OF BIOMARKERS FOR KERATOCONUS PROGRESSION
    • PCT/SG2014/000219, METHOD OF DIAGNOSING THYROID DISEASE
    • PCT/SG2014/000428, IDENTIFICATION OF NOVEL BIOMARKERS OF FLARES OF SYSTEMIC LUPUS ERYTHEMATOSUS

     

    Selected recent publications (from 55 peer-reviewed publications and 1 book chapter):

    1. Barathi VA, Chaurasia SS, Poidinger M, Koh SK, Tian D, Ho C, Iuvone MP, Beuerman RW, Zhou L*. Involvement of GABA transporters in Atropine-treated Myopic Retina as revealed by iTRAQ Quantitative Proteomics. Journal of Proteome Research. 2014, Nov. 7; 13(11): 4647-4658. *corresponding author. (IF: 5.001)
    2. Zhou L*, Wei Ruihua, Zhao Ping, Koh Siew Kwan, Beuerman Roger W, Ding Chuanqing, Proteomic Analysis Revealed the Altered Tear Protein Profile in a Rabbit Model of Sjögren’s Syndrome-Associated Dry Eye. 2013, Proteomics, 13(16), 2469-2481. *corresponding author. (IF: 4.615)
    3. Zhou L, Beuerman RW. Tear analysis in ocular surface diseases. Progress in Retinal and Eye Research, 2012, 31(6), 527-550. (IF: 10.307)
    4. Zhou L*, Zhao SZ, Koh SK, Chen L, Vaz C, Tanavde V, Li XR, Beuerman RW. In-depth analysis of the human tear proteome. Journal of Proteomics, 2012, 75(13), 3877-3885. *corresponding author. (IF: 5.080)
    5. Chen L, Zhou L*, Chan E, Neo J, Beuerman, RW, Characterization of The Human Tear Metabolome by LC-MS/MS. Journal of Proteome Research. 2011, Oct 7;10(10):4876-82.* Corresponding author. (IF: 5.617)
    6. Zhou L, Liu SP, Li J, Ong LB, Guo L, Wohland T, Tang C, R. Lakshminarayanan, Mavinahalli J, Verma C, Beuerman RW. The structural parameters to antimicrobial activity, human epithelia cell cytotoxicity and killing mechanism of 10-AA synthetic analogues and covalent dimer derived from hBD3 C-terminal. Amino Acids. 2011 Jan;40(1):123-33. (IF: 4.132)
    7. Wong TT, Zhou L, Li J, Tong L, Zhao SZ, Li XR, Yu SJ, Koh SK, Beuerman RW, Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication, Invest. Ophthalmol. Vis. Sci. 2011, Sep 22;52(10):7385-91. (IF: 3.832)
    8. Zhou L, Beuerman RW, Chan CM, Zhao SZ, Li XR, Yang H, Tong L, Liu SP, Stern ME, Tan DTH. Identification of Tear Fluid Biomarkers in Dry Eye Syndrome Using iTRAQ Quantitative Proteomics. Journal of Proteome Research, 2009, 8(11), 4889-4905. (IF: 5.737)
    9. Wong TT, Zhou L, Li J, Tong L, Zhao SZ, Li XR, Yu SJ, Koh SK, Beuerman RW, Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication, Invest. Ophthalmol. Vis. Sci. 2011, Sep 22;52(10):7385-91. (IF: 3.933)
    10. Zhou L, Beuerman RW, Chew AP, Koh SK, Cafaro TA, Urrets-Zavalia EA, Urrets-Zavalia JA, Li SFY, Serra HM. Quantitative Analysis of N-linked Glycoproteins in Tear Fluid of Climatic Droplet Keratopathy by Glycopeptide Capture and iTRAQ. Journal of Proteome Research, 2009, 8(4), 1992-2003. (IF: 5.737)
    11. Zhou L, Beuerman RW, Ang LPK, Chan CM, Li SFY, Chew FT, Tan DTH. Elevation of human -defensins and S100 calcium binding proteins A8 and A9 in tear fluid of pterygium patients. Invest. Ophthalmol. Vis. Sci., 2009, 50(5), 2077-2086. (IF: 3.832)
    12. Liu S*, Zhou L*, Li J*, Suresh A, Verma CS, Foo YH, Yap E, Tan D and Beuerman RW. Linear Analogues of Human b-Defensin 3: Concepts for Design of Antimicrobial Peptides with Reduced Cytotoxicity to Mammalian Cells. ChemBioChem, 2008, 9, 964-973. *Co-first author. (IF: 3.944)
    13. Zhou L, Beuerman RW, Huang LQ, Liu SP, Barathi A, Foo YH, Li SFY, Chew FT, Tan D. Proteomic Analysis of Rabbit Tear Fluid: Defensin Levels After An Experimental Corneal Wound Are Correlated to Wound Closure. Proteomics, 2007 7(17) 3194-3206. Figures on Front Cover page. Featured article in this issue. Podcast internationally. (IF: 5.809)
    14. Kho KW, Shen ZX, Zhou L, Watt F, Soo KC, Olivo M. Investigation into a surface plasmon related heating effect in surface enhanced Raman spectroscopy. Anal Chem. 2007 Dec 1;79(23):8870-82. Epub 2007 Oct 24. (IF: 5.900)
    15. Zhou L, Huang LQ, Beuerman RW, Grigg ME, Li SFY, Chew FT, Ang L, Stern ME, Tan D. Proteomic Analysis of Human Tears: Defensin Expression after Ocular Surface Surgery. Journal of Proteome Research, 2004, 3(3): 410-416. (IF: 6.917)