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Singapore Advanced Imaging Laboratory for Ocular Research (SAILOR)

ocular-imaging1a

The eye offers an exceptional opportunity for advanced imaging technology to document, monitor and study eye and systemic diseases. The Singapore Advanced Imaging Laboratory for Ocular Research (SAILOR) or Singapore Eye Research Institute (SERI) Ocular Imaging Unit, is the culmination of > 10 years of close collaboration between SERI, A*STAR’s Institute for Infocomm Research (I2R) and the National University of Singapore (NUS). It serves as a multi-disciplinary, translational clinical research facility that brings together the strengths of these three dynamic institutes.

Clinical-Ocular-Imaging1

Our Mission
SAILOR aims to be the leading ocular imaging and reading centre in Asia Pacific. We provide a comprehensive range of services in ocular imaging analysis and grading. Our overall aim is to build world-leading capability in computer-aided analysis of ocular images for the detection, prediction and treatment of eye diseases (diabetic retinopathy, age-related macular degeneration glaucoma, pathologic myopia, cataract, corneal disease), and for understanding the microvascular pathology in cardiovascular and cerebrovascular diseases.

SAILOR aims to be the leading ocular imaging and reading centre in Asia Pacific. We provide a comprehensive range of services in ocular imaging analysis and reading. Our overall aim is to build world-leading capability in computer-aided analysis of ocular images for the detection, prediction and treatment of eye diseases (diabetic retinopathy, age-related macular degeneration glaucoma, pathologic myopia, cataract, corneal disease), and for understanding the microvascular pathology in cardiovascular and cerebrovascular diseases.

What We Do

  1. Test-bed for validation of the suite of software technologies in various stages of development.

  2. Provide training and certification of graders according to clinical trial standards.

  3. Reading services on different eye diseases for clinical trials and research studies.

  4. Reading services on measurement of vascular or blood-vessel structure from retina images with computer-aided programs.

  5. Storage and archival of ocular images.

Our Technologies
We have 19 patents on various technologies such as:

  1. Glaucoma screening software with automated detection of optic cup-to-disc ratio, and landmark-based glaucoma diagnosis system and architecture

  2. Quantification of retinal vasculature for assessment of human microcirculations

  3. Automated detection of age-related macular degeneration

  4. Automated detection of diabetic retinopathy

  5. Automated grading system of lens opacity for cataract diagnosis

  6. System for pathological myopia detection

Clinical-Ocular-Imaging2

Our Licenses
We have licensing deals to >20 companies, institutions and hospitals globally that include:

  1. Centre of Eye Research Australia (CERA), Australia

  2. Manchester Royal Eye Hospital, UK

  3. Beijing Institute of Ophthalmology, China

  4. University of Wisconsin-Madison, USA

  5. University of Odense, Netherlands

  6. Moorfields Eye Hospital, UK

  7. Kyoto University, Japan

  8. Gostrup Hospital, Netherland

  9. Lion’s Eye Institute, Australia

  10. Yamagata University, Japan

  11. Eye IC, Inc

  12. Chinese University of Hong Kong, Hong Kong

  13. RMIT University, Australia

  14. Topcon Private Ltd, Japan

 

Our Prestigious Awards

  • 2014
  • President’s Technology Award, The President’s Science and Technology Awards, Singapore
  • 2014
  • Singapore Translational Research (STaR) Investigator Award, National Medical Research Council (NMRC)
  • 2010
  • Academic Centre of Excellence (ACE) Award, GlaxoSmithKline

     

    Ocular-Imaging

    1. Cheung CY, et al. Microvascular network alterations in the retina of patients with Alzheimer’s disease. Alzheimers Dement. 2014 Mar;10(2):135-42.

    2. Ding J, et al. Retinal vascular caliber and the development of hypertension: a meta-analysis of individual participant data. J Hypertens. 2014 Feb;32(2):207-15.

    3. Sabanayagam C, et al. Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia. 2015 Nov;58(11):2476-85.

    4. Cheung CY et al. Retinal microvascular changes and risk of stroke: the Singapore Malay Eye Study. Stroke. 2013 Sep;44(9):2402-8.

    5. Ong YT, et al. Microvascular structure and network in the retina of patients with ischemic stroke. Stroke. 2013 Aug;44(8):2121-7.

    6. Ikram MK et al. NIH/JDRF Workshop on Retinal Biomarker for Diabetes Group. Retinal vascular caliber as a biomarker for diabetes microvascular complications. Diabetes Care. 2013 Mar;36(3):750-9.

    7. Cheung CY, et al. Quantitative and qualitative retinal microvascular characteristics and blood pressure. J Hypertens. 2011 Jul;29(7):1380-91.

    8. Kawasaki R, et al. Fractal dimension of the retinal vasculature and risk of stroke: a nested case-control study. Neurology. 2011 May 17;76(20):1766-7.

    9. Benitez-Aguirre P, et al. Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence. Diabetes Care. 2011 Jul;34(7):1622-7.

    10. Cheung CY, et al. A new method to measure peripheral retinal vascular caliber over an extended area. Microcirculation. 2010 Oct;17(7):495-503.

    11. Cheung N, et al. Retinal fractals and acute lacunar stroke. Ann Neurol. 2010 Jul;68(1):107-11.

    12. Cheung N, et al. Quantitative assessment of early diabetic retinopathy using fractal analysis. Diabetes Care. 2009 Jan;32(1):106-10

    Contact Details:

    Ms Haslina bte Hamzah

    Senior Manager, Imaging Unit

    Email: haslina.hamzah@seri.com.sg

     

    Ms Ho Kee Ka

    Project Coordinator, Imaging Unit

    Email: ho.kee.ka@seri.com.sg